About: A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection

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About: A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection
Creator	Green, Michael Englund, Janet Halasa, Natasha Danziger-Isakov, Lara Dulek, Daniel Munoz, Flor Steinbach, William Michaels, Marian Paulsen, Grant Fisher, Brian Herold, Betsy Madan, Rebecca Murray, Alastair Sweet, Leigh
Source	Medline; PMC
abstract	BACKGROUND: Respiratory virus infection (RVI) in pediatric solid organ transplant (SOT) recipients poses a significant risk; however, the epidemiology and effects of an RVI after pediatric SOT in the era of current molecular diagnostic assays are unclear. METHODS: A retrospective observational cohort of pediatric SOT recipients (January 2010 to June 2013) was assembled from 9 US pediatric transplant centers. Charts were reviewed for RVI events associated with hospitalization within 1 year after the transplant. An RVI diagnosis required respiratory symptoms and detection of a virus (ie, human rhinovirus/enterovirus, human metapneumovirus, influenza virus, parainfluenza virus, coronavirus, and/or respiratory syncytial virus). The incidence of RVI was calculated, and the association of baseline SOT factors with subsequent pulmonary complications and death was assessed. RESULTS: Of 1096 pediatric SOT recipients (448 liver, 289 kidney, 251 heart, 66 lung, 42 intestine/multivisceral), 159 (14.5%) developed RVI associated with hospitalization within 12 months after their transplant. RVI occurred at the highest rates in intestine/abdominal multivisceral (38%), thoracic (heart/lung) (18.6%), and liver (15.6%) transplant recipients and a lower rate in kidney (5.5%) transplant recipients. RVI was associated with younger median age at transplant (1.72 vs 7.89 years; P < .001) and among liver or kidney transplant recipients with the receipt of a deceased-donor graft compared to a living donor (P = .01). The all-cause and attributable case-fatality rates within 3 months of RVI onset were 4% and 0%, respectively. Multivariable logistic regression models revealed that age was independently associated with increased risk for a pulmonary complication (odds ratio, 1.24 [95% confidence interval, 1.02–1.51]) and that receipt of an intestine/multivisceral transplant was associated with increased risk of all-cause death (odds ratio, 24.54 [95% confidence interval, 1.69–327.96]). CONCLUSIONS: In this study, hospital-associated RVI was common in the first year after pediatric SOT and associated with younger age at transplant. All-cause death after RVI was rare, and no definitive attributable death occurred.
has issue date	2018-03-10(xsd:dateTime)
bibo:doi	10.1093/jpids/piy024
bibo:pmid	29538674
has license	no-cc
sha1sum (hex)	1fe8ab9531a38af72ffad1460b1a821a1e58433d
schema:url	https://doi.org/10.1093/jpids/piy024
resource representing a document's title	A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection
has PubMed Central identifier	PMC7107524
has PubMed identifier	29538674
schema:publication	J Pediatric Infect Dis Soc
resource representing a document's body	covid:1fe8ab9531a38af72ffad1460b1a821a1e58433d#body_text
is schema:about of	named entity 'molecular diagnostic' named entity 'Infection' named entity 'SOLID ORGAN TRANSPLANT' named entity 'PEDIATRIC' named entity 'SOT' named entity 'SIGNIFICANT' named entity 'CURRENT' covid:arg/1fe8ab9531a38af72ffad1460b1a821a1e58433d named entity 'RESPIRATORY VIRUS INFECTION' named entity 'MOLECULAR' named entity 'OUTCOMES' named entity 'PEDIATRIC' named entity 'EPIDEMIOLOGY' named entity 'CONSORTIUM' named entity 'SOLID ORGAN TRANSPLANT' named entity 'INPATIENT' named entity 'TRANSPLANT RECIPIENTS' named entity 'ERA' named entity 'EPIDEMIOLOGY' named entity 'RESPIRATORY VIRUS INFECTION' named entity 'RISK' named entity 'EFFECTS' named entity 'DIAGNOSTIC' named entity 'UNCLEAR' named entity 'pediatric' named entity 'SOT' named entity 'molecular diagnostic' named entity 'Multicenter' named entity 'poses' named entity 'antiviral agent' named entity 'SOT' named entity 'SOT' named entity 'viruses' named entity '5.7%' named entity 'subacute' named entity 'human metapneumovirus' named entity 'pathogen' named entity 'bronchoalveolar lavage' named entity 'lung' named entity 'abdominal organs' named entity 'pediatric' named entity 'logistic regression' named entity 'outpatient setting' named entity 'hMPV' named entity 'liver' named entity 'pathogen' named entity 'loss to follow-up' named entity 'rhinovirus' named entity 'lung' named entity 'liver' named entity 'case-fatality rate' named entity 'bronchiolitis obliterans' named entity '7.5' named entity 'influenza' named entity 'hospital-associated' named entity 'intestine' named entity 'liver' named entity 'liver transplant from a living donor' named entity 'coronavirus' named entity 'respiratory support' named entity 'rhinovirus' named entity 'SOT' named entity 'risk of death' named entity 'sequelae' named entity 'organ' named entity 'odds ratio' named entity 'intestine' named entity 'systemic illness'

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