About: Recent developments in antiviral agents against enterovirus 71 infection

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About: Recent developments in antiviral agents against enterovirus 71 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recent developments in antiviral agents against enterovirus 71 infection
Creator	Sam, I-Ching Chan, Yoke Chee, Wah Tan, Kam, Jeffrey Lai, Fatt
Source	PMC
abstract	Enterovirus 71 (EV-71) is the main etiological agent of hand, foot and mouth disease (HFMD). Recent EV-71 outbreaks in Asia-Pacific were not limited to mild HFMD, but were associated with severe neurological complications such as aseptic meningitis and brainstem encephalitis, which may lead to cardiopulmonary failure and death. The absence of licensed therapeutics for clinical use has intensified research into anti-EV-71 development. This review highlights the potential antiviral agents targeting EV-71 attachment, entry, uncoating, translation, polyprotein processing, virus-induced formation of membranous RNA replication complexes, and RNA-dependent RNA polymerase. The strategies for antiviral development include target-based synthetic compounds, anti-rhinovirus and poliovirus libraries screening, and natural compound libraries screening. Growing knowledge of the EV-71 life cycle will lead to successful development of antivirals. The continued effort to develop antiviral agents for treatment is crucial in the absence of a vaccine. The coupling of antivirals with an effective vaccine will accelerate eradication of the disease.
has issue date	2014-02-12(xsd:dateTime)
bibo:doi	10.1186/1423-0127-21-14
bibo:pmid	24521134
has license	cc-by
sha1sum (hex)	1fdefb8aa4368ef11e32bad469c37591b0eb24bc
schema:url	https://doi.org/10.1186/1423-0127-21-14
resource representing a document's title	Recent developments in antiviral agents against enterovirus 71 infection
has PubMed Central identifier	PMC3924904
has PubMed identifier	24521134
schema:publication	J Biomed Sci
resource representing a document's body	covid:1fdefb8aa4368ef11e32bad469c37591b0eb24bc#body_text
is schema:about of	named entity 'processing' named entity 'mouth' named entity 'disease' named entity 'develop' named entity 'compounds' named entity 'encephalitis' named entity 'licensed' named entity 'aseptic meningitis' named entity 'lead' named entity 'FOOT AND MOUTH DISEASE' named entity 'VACCINE' named entity 'BASED' named entity 'FORMATION' named entity 'CLINICAL' named entity 'CONTINUED' named entity 'SEVERE' named entity 'ABSENCE OF' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'EFFORT' named entity 'BRAINSTEM ENCEPHALITIS' named entity 'ATTACHMENT' named entity 'MAIN' named entity 'INDUCED' named entity 'COUPLING' named entity 'ASIA' named entity 'SCREENING' named entity 'ANTIVIRAL AGENTS' named entity 'ENTRY' named entity 'HFMD' named entity 'PROCESSING' named entity 'HAND' named entity 'NEUROLOGICAL' named entity 'MEMBRANOUS' named entity 'BUT' named entity 'USE' named entity 'DEVELOPMENT' named entity 'OUTBREAKS' named entity 'MILD' named entity 'REVIEW' named entity 'INCLUDE' named entity 'ANTIVIRAL' named entity 'DISEASE' named entity 'RECENT' named entity 'STRATEGIES' named entity 'POTENTIAL' named entity 'LICENSED' named entity 'KNOWLEDGE' named entity 'COMPLEXES' named entity 'RESEARCH' named entity 'RECENT' named entity 'DEVELOPMENTS' named entity 'AGENT' named entity 'ENTEROVIRUS 71 INFECTION' named entity 'NATURAL COMPOUND' named entity 'TRANSLATION' named entity 'SUCCESSFUL' named entity 'LIBRARIES' named entity 'COMPLICATIONS' named entity 'LEAD' named entity 'ASEPTIC MENINGITIS' named entity 'ERADICATION' named entity 'GROWING' named entity 'RNA REPLICATION' named entity 'RHINOVIRUS' named entity 'THERAPEUTICS' named entity 'CARDIOPULMONARY FAILURE' named entity 'SYNTHETIC' named entity 'ASSOCIATED WITH' named entity 'LIFE CYCLE' named entity 'ACCELERATE' named entity 'POLYPROTEIN' named entity 'TARGETING' named entity 'LIMITED' named entity 'POLIOVIRUS' named entity 'ANTIVIRAL AGENTS' named entity 'ANTIVIRALS'

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