About: Prediction of mutations engineered by randomness in H5N1 hemagglutinins of influenza A virus

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About: Prediction of mutations engineered by randomness in H5N1 hemagglutinins of influenza A virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Prediction of mutations engineered by randomness in H5N1 hemagglutinins of influenza A virus
Creator	Wu, G Yan, S
source	PMC
abstract	This is the continuation of our studies on the prediction of mutation engineered by randomness in proteins from influenza A virus. In our previous studies, we have demonstrated that randomness plays a role in engineering mutations because the measures of randomness in protein are different before and after mutations. Thus we built a cause-mutation relationship to count the mutation engineered by randomness, and conducted several concept-initiated studies to predict the mutations in proteins from influenza A virus, which demonstrated the possibility of prediction of mutations along this line of thought. On the other hand, these concept-initiated studies indicate the directions forwards the enhancement of predictability, of which we need to use the neural network instead of logistic regression that was used in those concept-initiated studies to enhance the predictability. In this proof-of-concept study, we attempt to apply the neural network to modeling the cause-mutation relationship to predict the possible mutation positions, and then we use the amino acid mutating probability to predict the would-be-mutated amino acids at predicted positions. The results confirm the possibility of use of internal cause-mutation relationship with neural network model to predict the mutation positions and use of amino acid mutating probability to predict the would-be-mutated amino acids.
has issue date	2007-11-02(xsd:dateTime)
bibo:doi	10.1007/s00726-007-0602-4
bibo:pmid	17973072
has license	no-cc
sha1sum (hex)	1fd124821f7eedea3ffbf092113a33cb8c3e58e0
schema:url	https://doi.org/10.1007/s00726-007-0602-4
resource representing a document's title	Prediction of mutations engineered by randomness in H5N1 hemagglutinins of influenza A virus
has PubMed Central identifier	PMC7088403
has PubMed identifier	17973072
schema:publication	Amino Acids
resource representing a document's body	covid:1fd124821f7eedea3ffbf092113a33cb8c3e58e0#body_text
is schema:about of	named entity 'predict' named entity 'mutations' named entity 'engineered' named entity 'logistic regression' named entity 'proof-of-concept' named entity 'studies' named entity 'count' named entity 'CONFIRM' named entity 'RESULTS' named entity 'HAVE' named entity 'FORWARDS' named entity 'ATTEMPT' named entity 'MODELING' named entity 'DEMONSTRATED' named entity 'MUTATED' named entity 'CONTINUATION' named entity 'POSITIONS' named entity 'PREDICTED' named entity 'LOGISTIC REGRESSION' named entity 'USED' named entity 'H5N1' named entity 'ENGINEERED' named entity 'ENGINEERED' named entity 'ENHANCE' named entity 'AMINO ACID' named entity 'THESE' named entity 'CAUSE' named entity 'HAND' named entity 'INFLUENZA A VIRUS' named entity 'PREDICTION' named entity 'HEMAGGLUTININS' named entity 'ENGINEERING' named entity 'POSSIBILITY OF' named entity 'LINE' named entity 'DIRECTIONS' named entity 'PLAYS' named entity 'PROBABILITY' named entity 'INFLUENZA A VIRUS' named entity 'ROLE' named entity 'INTERNAL' named entity 'USE' named entity 'TO COUNT' named entity 'STUDY' named entity 'DIFFERENT' named entity 'MUTATIONS' named entity 'MUTATION' named entity 'PROOF' named entity 'POSSIBLE' named entity 'OF-' named entity 'NEED' named entity 'PROTEIN ' named entity 'PREDICTION' named entity 'OUR' named entity 'ENHANCEMENT' named entity 'RELATIONSHIP' named entity 'PREDICT' named entity 'NEURAL NETWORK' named entity 'PROTEINS' named entity 'STUDIES' named entity 'AMINO ACIDS' named entity 'USE OF' named entity 'THOUGHT' named entity 'CONCEPT' named entity 'MUTATIONS' named entity 'NEURAL NETWORK MODEL' named entity 'APPLY' named entity 'MEASURES' named entity 'PREVIOUS' covid:arg/1fd124821f7eedea3ffbf092113a33cb8c3e58e0 named entity 'internal' named entity 'influenza A virus' named entity 'randomness' named entity 'Prediction' named entity 'mutations' named entity 'probability' named entity 'neural network' named entity 'amino acids' named entity 'mutation' named entity 'mutation' named entity 'amino acid'

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