About: Sensitivity and specificity of double-blinded penicillin skin testing in relation to oral provocation with amoxicillin in children

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Sensitivity and specificity of double-blinded penicillin skin testing in relation to oral provocation with amoxicillin in children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Sensitivity and specificity of double-blinded penicillin skin testing in relation to oral provocation with amoxicillin in children
Creator	Bégin, Philippe Labrosse, Roxane Lacombe-Barrios, Jonathan Paradis, Jean Paradis, Louis Samaan, Kathryn Des, Anne
source	PMC
abstract	Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicillin. However, the role of PST is increasingly questioned in the pediatric setting. To resolve the question of PST’s diagnostic accuracy, consecutive children with a history of non-life-threatening penicillin allergy referred to a tertiary-care allergy center were recruited to undergo double-blinded PST with PPL and BP prior to drug provocation to amoxicillin. Five of 158 participants (3.2%) presented with an immediate or accelerated reaction upon amoxicillin challenge, none of which were severe. Only one of these had positive PST (20%), compared to 15 of 153 amoxicillin tolerant participants (9.8%). The sensitivity and specificity of PST with PPL and BP for reacting upon amoxicillin challenge were 20% (95% CI: 0.5–71.6%) and 90% (95% CI: 84.4–94.4%), respectively. These results argue against the routine use of PST as a preliminary step to drug provocation with amoxicillin in this population, as it is unlikely to significantly alter pre-test probability of reacting to challenge.
has issue date	2020-07-01(xsd:dateTime)
bibo:doi	10.1186/s13223-020-00449-7
has license	cc-by
sha1sum (hex)	1fbaea075097eb71cf36fc442a239de5bf9dc01c
schema:url	https://doi.org/10.1186/s13223-020-00449-7
resource representing a document's title	Sensitivity and specificity of double-blinded penicillin skin testing in relation to oral provocation with amoxicillin in children
has PubMed Central identifier	PMC7371808
schema:publication	Allergy Asthma Clin Immunol
resource representing a document's body	covid:1fbaea075097eb71cf36fc442a239de5bf9dc01c#body_text
is schema:about of	named entity 'management' named entity 'skin testing' named entity 'pre-test probability' named entity 'amoxicillin' named entity 'relation' named entity 'skin testing' named entity 'TOLERANT' named entity 'PENICILLIN' named entity 'PRE' named entity '158' named entity 'MANAGEMENT' named entity 'DOUBLE-BLINDED' named entity 'PROBABILITY OF' covid:arg/1fbaea075097eb71cf36fc442a239de5bf9dc01c named entity 'sensitivity' named entity 'pediatric' named entity '95% CI' named entity 'amoxicillin' named entity 'tolerant' named entity 'referred' named entity 'Five' named entity 'provocation' named entity 'life-threatening' named entity 'benzylpenicillin' named entity 'amoxicillin' named entity '95% CI' named entity 'Asthma' named entity 'recruited' named entity 'prick test' named entity 'SCARs' named entity 'histamine' named entity 'cutaneous' named entity 'Study population' named entity 'provocation test' named entity '95% CI' named entity 'anti-histamines' named entity 'cutaneous' named entity 'allergist' named entity 'true allergy' named entity 'hypotension' named entity 'Skin tests' named entity 'informed consent' named entity 'antihistamine' named entity 'allergy' named entity 'infectious process' named entity 'negative result' named entity 'drug allergy' named entity 'allergist' named entity 'test sensitivity' named entity 'Canada' named entity 'screening tool' named entity 'saline' named entity 'injectable' named entity 'infection' named entity 'Canada' named entity 'anaphylactic shock' named entity 'amoxicillin' named entity 'gold standard' named entity 'life-threatening' named entity 'Richmond Hill, Ontario' named entity 'diagnostic accuracy' named entity 'drug hypersensitivity' named entity 'double-blinded' named entity 'ethics committee' named entity 'interpretation bias' named entity 'IgE' named entity 'allergy' named entity 'consciousness' named entity 'subgroup analysis' named entity 'true allergy' named entity 'penicillin allergy' named entity 'maculopapular rash' named entity 'pediatric' named entity '95% confidence interval' named entity 'double-blinded' named entity 'ethics committee' named entity 'penicillin'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software