About: Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates

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About: Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates
Creator	Pickles, Raymond Murphy, Brian Amaro-Carambot, Emerito Nishio, Machiko Schaap-Nutt, Anne Collins, Peter D'angelo, Christopher Schmidt, Alexander Scull, Margaret
Source	Elsevier; Medline; PMC
abstract	In wild-type human parainfluenza virus type 2 (WT HPIV2), one gene (the P/V gene) encodes both the polymerase-associated phosphoprotein (P) and the accessory V protein. We generated a HPIV2 virus (rHPIV2-V(ko)) in which the P/V gene encodes only the P protein to examine the role of V in replication in vivo and as a potential live attenuated virus vaccine. Preventing expression of V protein severely impaired virus recovery from cDNA and growth in vitro, particularly in IFN-competent cells. rHPIV2-V(ko), unlike WT HPIV2, strongly induced IFN-β and permitted IFN signaling, leading to establishment of a robust antiviral state. rHPIV2-V(ko) infection induced extensive syncytia and cytopathicity that was due to both apoptosis and necrosis. Replication of rHPIV2-V(ko) was highly restricted in the respiratory tract of African green monkeys and in differentiated primary human airway epithelial (HAE) cultures, suggesting that V protein is essential for efficient replication of HPIV2 in organized epithelial cells and that rHPIV2-V(ko) is over-attenuated for use as a live attenuated vaccine.
has issue date	2010-02-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.11.018
bibo:pmid	19969320
has license	green-oa
sha1sum (hex)	1fb8771c4defe74b3986b6558a0f02d737712269
schema:url	https://doi.org/10.1016/j.virol.2009.11.018
resource representing a document's title	Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates
has PubMed Central identifier	PMC2822077
has PubMed identifier	19969320
schema:publication	Virology
resource representing a document's body	covid:1fb8771c4defe74b3986b6558a0f02d737712269#body_text
is schema:about of	named entity 'human parainfluenza virus' named entity 'human' named entity 'green monkeys' named entity 'wild-type' named entity 'protein' named entity 'primates' named entity 'PRIMATES' named entity 'ESTABLISHMENT' named entity 'POLYMERASE' named entity 'IN VITRO' named entity 'WILD-TYPE' named entity 'GENE' named entity 'PROTEIN ' named entity 'LEADING' named entity 'APOPTOSIS AND NECROSIS' named entity 'DUE TO' named entity 'LIVE ATTENUATED VIRUS' named entity 'SYNCYTIA' named entity 'PERMITTED' named entity 'HIGHLY' named entity 'EXPRESSION' named entity 'CDNA' named entity 'IN VIVO' named entity 'PHOSPHOPROTEIN' named entity 'INFECTION INDUCED' named entity 'ORGANIZED' named entity 'USE' named entity 'IMPAIRED' named entity 'RESPIRATORY TRACT' named entity 'V PROTEIN' named entity 'ESSENTIAL' named entity 'V PROTEIN' named entity 'EFFICIENT' named entity 'SEVERELY' named entity 'INDUCED' named entity 'HUMAN' named entity 'NON-' named entity 'ANTIVIRAL' named entity 'VIRUS VACCINE' named entity 'PRIMARY' named entity 'COMPETENT' named entity 'ASSOCIATED' named entity 'RECOVERY' named entity 'GENERATED' named entity 'AIRWAY' named entity 'HUMAN PARAINFLUENZA VIRUS TYPE 2' named entity 'ROBUST' named entity 'REPLICATION' named entity 'CELLS' named entity 'PREVENTING' named entity 'ROLE' named entity 'CULTURES' named entity 'P PROTEIN' named entity 'ATTENUATED' named entity 'EPITHELIAL CELLS' named entity 'TO EXAMINE' named entity 'INTERFERON PRODUCTION' named entity 'PROTEIN ' named entity 'EXTENSIVE' named entity 'AFRICAN GREEN MONKEYS' named entity 'STATE' named entity 'RESTRICTED' named entity '28P' named entity 'IFN' named entity 'SIGNALING' named entity 'LIVE ATTENUATED VACCINE' named entity 'EPITHELIAL' named entity 'GROWTH' named entity 'ACCESSORY' named entity 'HUMAN' named entity 'POTENTIAL' named entity 'REQUIRED' named entity 'VIRUS'

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