About: Pharmaceutical Prescription in Canine Acute Diarrhoea: A Longitudinal Electronic Health Record Analysis of First Opinion Veterinary Practices

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pharmaceutical Prescription in Canine Acute Diarrhoea: A Longitudinal Electronic Health Record Analysis of First Opinion Veterinary Practices
Creator	Dawson, Susan Sánchez-Vizcaíno, Fernando Jones, Philip Pinchbeck, Gina Moreno, Miguel Dorado García, Alejandro Luisa, Ana Mateus, Pereira Noble, P Radford, Alan Singleton, David Williams, Nicola
Source	Medline; PMC
abstract	Canine acute diarrhoea is frequently observed in first opinion practice, though little is known about commonly used diagnostic or therapeutic management plans, including use of antimicrobials. This retrospective observational study utilised electronic health records augmented with practitioner-completed questionnaires from 3,189 cases (3,159 dogs) collected from 179 volunteer veterinary practices between April 2014 and January 2017. We used multivariable analysis to explore factors potentially associated with pharmaceutical agent prescription, and resolution of clinical signs by 10 days post-initial presentation. Use of bacteriological and/or parasitological diagnostic tests were uncommon (3.2% of cases, 95% confidence interval, CI, 2.4–4.0), though systemic antimicrobials were the most commonly prescribed pharmaceutical agents (49.7% of cases, 95% CI 46.1–53.2). Such prescription was associated with haemorrhagic diarrhoea (odds ratio, OR, 4.1; 95% CI 3.4–5.0), body temperature in excess of 39.0°C, or moderate/severe cases (OR 1.3, 95% CI 1.1–1.7). Gastrointestinal agents (e.g., antacids) were prescribed to 37.7% of cases (95% CI 35.4–39.9), and were most frequently prescribed to vomiting dogs regardless of presence (OR 46.4, 95% CI 19.4–110.8) or absence of blood (OR 17.1, 95% CI 13.4–21.9). Endoparasiticides/endectocides were prescribed to 7.8% of cases (95% CI 6.8–9.0), such prescription being less frequent for moderate/severe cases (OR 0.5, 95% CI 0.4–0.7), though more frequent when weight loss was recorded (OR 3.4, 95% CI 1.3–9.0). Gastrointestinal nutraceuticals (e.g., probiotics) were dispensed to 60.8% of cases (95% CI 57.1–64.6), these cases less frequently presenting with moderate/severe clinical signs (OR 0.6, 95% CI 0.5–0.8). Nearly a quarter of cases were judged lost to follow-up (n=754). Insured (OR 0.7, 95% CI 0.5–0.9); neutered (OR 0.4, 95% CI 0.3–0.5), or vaccinated dogs (OR 0.3, 95% CI 0.3–0.4) were less commonly lost to follow-up. Of remaining dogs, clinical signs were deemed resolved in 95.4% of cases (95% CI 94.6–96.2). Provision of dietary modification advice and gastrointestinal nutraceuticals alone were positively associated with resolution (OR 2.8, 95% CI 1.3–6.1); no such associations were found for pharmaceutical agents, including antimicrobials. Hence, this study supports the view that antimicrobials are largely unnecessary for acute diarrhoea cases; this being of particular importance when considering the global threat posed by antimicrobial resistance.
has issue date	2019-07-02(xsd:dateTime)
bibo:doi	10.3389/fvets.2019.00218
bibo:pmid	31334254
has license	cc-by
sha1sum (hex)	1f345c5a7a02b742ca70ce9233c80a200af974b6
schema:url	https://doi.org/10.3389/fvets.2019.00218
resource representing a document's title	Pharmaceutical Prescription in Canine Acute Diarrhoea: A Longitudinal Electronic Health Record Analysis of First Opinion Veterinary Practices
has PubMed Central identifier	PMC6615257
has PubMed identifier	31334254
schema:publication	Front Vet Sci
resource representing a document's body	covid:1f345c5a7a02b742ca70ce9233c80a200af974b6#body_text
is schema:about of	named entity 'pharmaceutical agent' named entity 'diagnostic tests' named entity 'posed' named entity 'Electronic Health Record' named entity 'REGARDLESS' named entity 'BLOOD' named entity '283' named entity 'KNOWN' named entity '0.9' named entity 'FREQUENTLY' named entity 'THESE' named entity 'JANUARY' named entity 'ANALYSIS' named entity 'VIEW' named entity 'ELECTRONIC HEALTH RECORD' named entity 'PRACTICES' named entity 'ARTICLE' named entity 'DAYS' named entity 'VETERINARY' named entity 'CASES' named entity 'COLLECTED' named entity 'DOGS' named entity '1-1' named entity '1.7' named entity 'ADVICE' named entity 'RESOLUTION' named entity 'USE OF' named entity 'FREQUENT' named entity 'INCLUDING' named entity 'INITIAL PRESENTATION' named entity 'PARTICULAR' named entity 'REMAINING' named entity 'PHARMACEUTICAL' named entity 'GLOBAL' named entity '2.4' named entity 'BODY TEMPERATURE' named entity '0.3' named entity 'VETERINARY' named entity '218' named entity 'ANALYSIS' named entity 'BEING' named entity 'ANTIMICROBIALS' named entity 'NEUTERED' named entity 'COMPLETED' named entity '179' named entity 'POST' named entity 'VOLUNTEER' named entity 'ABSENCE OF' named entity 'RATIO' named entity 'ANTACIDS' named entity '3.4' named entity 'ASSOCIATIONS' named entity 'VACCINATED' named entity '4-5' named entity '13.4' named entity 'EXCESS' named entity 'STUDY' named entity 'PRACTITIONER' named entity 'APRIL' named entity 'VOMITING' named entity 'PARASITOLOGICAL' named entity 'MANAGEMENT PLANS' named entity 'PRESCRIBED' named entity 'ASSOCIATED WITH' named entity '2849' named entity '1.1' named entity '0.6' named entity 'USED' named entity 'ACUTE DIARRHOEA' named entity 'DIAGNOSTIC'

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