About: Bioinformatics and evolutionary insight on the spike glycoprotein gene of QX-like and Massachusetts strains of infectious bronchitis virus

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About: Bioinformatics and evolutionary insight on the spike glycoprotein gene of QX-like and Massachusetts strains of infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bioinformatics and evolutionary insight on the spike glycoprotein gene of QX-like and Massachusetts strains of infectious bronchitis virus
Creator	Belák, Sándor Baule, Claudia Ullman, Karin Hussain, Shahid
Source	Medline; PMC
abstract	BACKGROUND: Infectious bronchitis virus (IBV) is a Gammacoronavirus of the family Coronaviridae and is a causative agent of an economically important disease in poultry. The spike glycoprotein of IBV is essential for host cell attachment, neutralization, and is involved in the induction of protective immunity. Previously obtained sequence data of the spike gene of IBV QX-like and Massachusetts strains were subjected to bioinformatics analysis. FINDINGS: On analysis of potential phosphorylation sites, the Ser542 and Ser563 sites were not present in Massachusetts strains, while QX-like isolates did not have the Ser534 site. Massachusetts and QX-like strains showed different cleavage site motifs. The N-glycosylation sites ASN-XAA-SER/THR-55, 147, 200 and 545 were additionally present in QX-like strains. The leucine-rich repeat regions in Massachusetts strains consisted of stretches of 63 to 69 amino acids, while in the QX-like strains they contained 59 amino acids in length. An additional palmitoylation site was observed in CK/SWE/082066/2010 a QX-like strain. Primary structure data showed difference in the physical properties and hydrophobic nature of both genotypes. The comparison of secondary structures revealed no new structural domains in the genotypic variants. The phylogenetic analyses based on avian and mammalian coronaviruses showed the analysed IBV as closely related to turkey coronaviruses and distantly related to thrush and munia coronaviruses. CONCLUSION: The study demonstrated that spike glycoprotein of the Massachusetts and the QX-like variants of IBV are molecularly distinct and that this may reflect in differences in the behavior of these viruses in vivo.
has issue date	2012-09-19(xsd:dateTime)
bibo:doi	10.1186/1743-422x-9-211
bibo:pmid	22992336
has license	cc-by
sha1sum (hex)	1f28ddf08dc9bb5b9b4c291f15d3d42ecdf9cde4
schema:url	https://doi.org/10.1186/1743-422x-9-211
resource representing a document's title	Bioinformatics and evolutionary insight on the spike glycoprotein gene of QX-like and Massachusetts strains of infectious bronchitis virus
has PubMed Central identifier	PMC3502414
has PubMed identifier	22992336
schema:publication	Virol J
resource representing a document's body	covid:1f28ddf08dc9bb5b9b4c291f15d3d42ecdf9cde4#body_text
is schema:about of	named entity 'analysis' named entity 'host' named entity 'strains' named entity 'BIOINFORMATICS ANALYSIS' named entity 'PREVIOUSLY' named entity 'BACKGROUND' named entity 'MASSACHUSETTS' named entity 'OBTAINED' named entity 'INVOLVED' named entity 'STRAINS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'POULTRY' named entity 'LIKE' named entity 'CAUSATIVE AGENT' named entity 'PROTECTIVE IMMUNITY' named entity 'LIKE' named entity 'MASSACHUSETTS' named entity 'INSIGHT' named entity 'GENE' named entity 'GAMMACORONAVIRUS' named entity 'ESSENTIAL' named entity 'IS A' named entity 'DISEASE' named entity 'SEQUENCE DATA' named entity 'ECONOMICALLY IMPORTANT' named entity 'INDUCTION' named entity 'HOST CELL' named entity 'NEUTRALIZATION' named entity 'CELL ATTACHMENT' named entity 'BIOINFORMATICS' named entity 'FAMILY CORONAVIRIDAE' named entity 'GENE' named entity 'STRAINS' named entity 'INFECTIOUS BRONCHITIS VIRUS' covid:arg/1f28ddf08dc9bb5b9b4c291f15d3d42ecdf9cde4 named entity 'bioinformatics' named entity 'IBV' named entity 'Gammacoronavirus' named entity 'glycoprotein' named entity 'Coronaviridae' named entity 'Massachusetts' named entity 'bioinformatics' named entity 'IBV' named entity 'cell attachment' named entity 'infectious bronchitis virus' named entity 'virus replication' named entity 'Numida' named entity 'bioinformatics' named entity 'virus' named entity 'domestic fowl' named entity 'bovine coronavirus' named entity 'guinea fowl' named entity 'genome' named entity 'IBV' named entity 'monoclonal antibody' named entity 'tissue tropism' named entity 'genotypically' named entity 'protein' named entity 'ecological niches' named entity 'primary structures' named entity 'standard deviation' named entity 'host cells' named entity 'viral infections' named entity 'proteases' named entity 'IBV' named entity 'bat' named entity 'thrush' named entity 'substitution rates' named entity 'genetic analysis' named entity 'serine proteases' named entity 'cellular level' named entity 'phenylalanine' named entity 'IBV' named entity 'coronavirus' named entity 'recognition sites' named entity 'glycoprotein' named entity 'hydrophobic' named entity 'PHEV'

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