About: Roles for the Recycling Endosome, Rab8, and Rab11 in hantavirus release from epithelial cells

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About: Roles for the Recycling Endosome, Rab8, and Rab11 in hantavirus release from epithelial cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Roles for the Recycling Endosome, Rab8, and Rab11 in hantavirus release from epithelial cells
Creator	Pekosz, Andrew Rowe, Regina Suszko, Jason
Source	Elsevier; Medline; PMC
abstract	Hantavirus structural proteins are believed to localize to intracellular membranes often identified as Golgi membranes, in virus-infected cells. After virus budding into the Golgi luminal space, virus-containing vesicles are transported to the plasma membrane via trafficking pathways that are not well defined. Using the New World hantavirus, Andes virus, we have investigated the role of various Rab proteins in the release of hantavirus particles from infected cells. Rabs 8 and 11 were found to colocalize with Andes virus proteins in virus infected cells and when expressed from cDNA, implicating the recycling endosome as an organelle important for hantavirus infection. Small interfering RNA-mediated downregulation of Rab11a alone or Rab11a and Rab11b together resulted in a decrease in infectious virus particle secretion from infected cells. Downregulation of Rab8a did not alter infectious virus release but reduction of both isoforms did. These data implicate the recycling endosome and the Rab proteins associated with vesicular transport to or from this intracellular organelle as an important pathway for hantavirus trafficking to the plasma membrane.
has issue date	2008-12-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2008.09.021
bibo:pmid	18951604
has license	green-oa
sha1sum (hex)	1f2490dbadb8402fc324520f92c4868bc4f53f3a
schema:url	https://doi.org/10.1016/j.virol.2008.09.021
resource representing a document's title	Roles for the Recycling Endosome, Rab8, and Rab11 in hantavirus release from epithelial cells
has PubMed Central identifier	PMC2648827
has PubMed identifier	18951604
schema:publication	Virology
resource representing a document's body	covid:1f2490dbadb8402fc324520f92c4868bc4f53f3a#body_text
is schema:about of	named entity 'plasma membrane' named entity 'intracellular' named entity 'recycling' named entity 'Roles' covid:arg/1f2490dbadb8402fc324520f92c4868bc4f53f3a named entity 'Andes virus' named entity 'virus' named entity 'trafficking' named entity 'luminal' named entity 'Golgi' named entity 'trafficking' named entity 'endosome' named entity 'hantavirus' named entity 'virus' named entity 'plasma membrane' named entity 'plasma membrane' named entity 'vesicles' named entity 'Andes virus' named entity 'Rab' named entity 'luminal' named entity 'virus particle' named entity 'hantavirus' named entity 'vesicular transport' named entity 'secretion' named entity 'intracellular membranes' named entity 'Hantavirus' named entity 'Rab11' named entity 'ANDV' named entity 'host cell' named entity 'restriction enzyme' named entity 'ANDV' named entity 'PBS' named entity 'ANDV' named entity 'LDLR' named entity 'restriction enzymes' named entity 'cis-Golgi' named entity 'colocalization' named entity 'SacI' named entity 'vesicular trafficking' named entity 'vector' named entity 'vector' named entity 'plasma membrane' named entity 'cell types' named entity 'N-terminal' named entity 'TGN' named entity 'Mountain View, CA' named entity 'secretion' named entity 'endosome' named entity 'nucleocapsid protein' named entity 'eGFP' named entity 'biosafety level 3' named entity 'Klenow' named entity 'viral particles' named entity 'Rabs' named entity 'herpes simplex virus' named entity 'colocalization' named entity 'ER-Golgi intermediate compartment' named entity 'Rab11a' named entity 'plasmid' named entity 'immunofluorescence' named entity 'ANDV' named entity 'ORF' named entity 'GTP' named entity 'critical role' named entity 'West Grove' named entity 'virus' named entity 'viruses' named entity 'PBS' named entity 'JEOL' named entity 'RNA' named entity 'Intracellular' named entity 'subcellular localization' named entity 'supernatants' named entity 'cell surface receptors' named entity 'New World' named entity 'Protein' named entity 'transfected' named entity 'ANDV' named entity 'virus'

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