About: Connecting clusters of COVID-19: an epidemiological and serological investigation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Connecting clusters of COVID-19: an epidemiological and serological investigation
Creator	Lee, Vernon Wang, Linfa Pang, Junxiong Vasoo, Shawn Chen, Mark I-Cheng Wei, Wycliffe Anderson, Danielle Leo, Yee Tan, Yee Chee, Wah Chia, Wan Ong, Benjamin Chia, Ying Koh, Joshua Ee, Sarah Han, Sim Leong Teoh, Priyanka Lum, Nur-Afidah Md, Suhaimi Poh, Valerie Rajendram, Matthias Toh, Cuiqin Yong, Fang
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Elucidation of the chain of disease transmission and identification of the source of coronavirus disease 2019 (COVID-19) infections are crucial for effective disease containment. We describe an epidemiological investigation that, with use of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays, established links between three clusters of COVID-19. METHODS: In Singapore, active case-finding and contact tracing were undertaken for all COVID-19 cases. Diagnosis for acute disease was confirmed with RT-PCR testing. When epidemiological information suggested that people might have been nodes of disease transmission but had recovered from illness, SARS-CoV-2 IgG serology testing was used to establish past infection. FINDINGS: Three clusters of COVID-19, comprising 28 locally transmitted cases, were identified in Singapore; these clusters were from two churches (Church A and Church B) and a family gathering. The clusters in Church A and Church B were linked by an individual from Church A (A2), who transmitted SARS-CoV-2 infection to the primary case from Church B (F1) at a family gathering they both attended on Jan 25, 2020. All cases were confirmed by RT-PCR testing because they had active disease, except for A2, who at the time of testing had recovered from their illness and tested negative. This individual was eventually diagnosed with past infection by serological testing. ELISA assays showed an optical density of more than 1·4 for SARS-CoV-2 nucleoprotein and receptor binding domain antigens in titres up to 1/400, and viral neutralisation was noted in titres up to 1/320. INTERPRETATION: Development and application of a serological assay has helped to establish connections between COVID-19 clusters in Singapore. Serological testing can have a crucial role in identifying convalescent cases or people with milder disease who might have been missed by other surveillance methods. FUNDING: National Research Foundation (Singapore), National Natural Science Foundation (China), and National Medical Research Council (Singapore).
has issue date	2020-04-21(xsd:dateTime)
bibo:doi	10.1016/s1473-3099(20)30273-5
bibo:pmid	32330439
has license	no-cc
sha1sum (hex)	1f09630649c6584bb2b34d55e282e31328fe466d
schema:url	https://doi.org/10.1016/s1473-3099%2820%2930273-5
resource representing a document's title	Connecting clusters of COVID-19: an epidemiological and serological investigation
has PubMed Central identifier	PMC7173813
has PubMed identifier	32330439
schema:publication	Lancet Infect Dis
resource representing a document's body	covid:1f09630649c6584bb2b34d55e282e31328fe466d#body_text
is schema:about of	named entity 'COVID-19' named entity 'investigation' named entity 'CONTAINMENT' named entity 'INVESTIGATION' named entity 'CLUSTERS' named entity 'assays' named entity 'COVID-19' named entity 'Background' named entity 'COVID' named entity 'COVID' named entity 'serological' named entity 'infection' named entity 'COVID' named entity 'CFR' named entity 'serum' named entity 'serological testing' named entity 'missing link' named entity 'asymptomatic' named entity 'serological' named entity 'infection' named entity 'MERS' named entity 'missing link' named entity 'China' named entity 'IgG' named entity 'SARS-CoV-2' named entity 'SARS' named entity 'health officials' named entity 'Wuhan' named entity 'epidemic' named entity 'Middle East respiratory syndrome' named entity 'asymptomatic' named entity 'epidemiological methods' named entity 'rapid diagnostic' named entity 'seroconverted' named entity '1/50' named entity 'epidemiological' named entity 'population immunity' named entity 'epidemiological' named entity 'epidemiological data' named entity 'SARS-CoV-2' named entity 'serological' named entity 'viruses' named entity 'RT-PCR test' named entity 'epidemiological' named entity 'infection' named entity 'IgG' named entity 'immunoglobulins' named entity 'COVID-19' named entity 'Singapore' named entity 'Chinese New Year' named entity 'IgM' named entity 'COVID-19' named entity 'epidemiological' named entity 'COVID' named entity 'quarantine' named entity 'serological tests' named entity 'quantitative RT-PCR' named entity 'contact tracing' named entity 'April 6'

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