About: Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

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About: Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection
Creator	Hammad, Hamida Neyt, Katrijn Saeys, Yvan Lambrecht, Bart Williams, David Bosteels, Cedric Bosteels, Victor De Prijck, Sofie Debeuf, Nincy Guilliams, Martin Lesage, Manon Louagie, Els Martens, Liesbet Mayer, Johannes Ronchese, Franca Scott, Charlotte Sichien, Dorine Tang, Shiau-Choot Vandamme, Niels Vanheerswynghels, Manon Van Helden, Mary
source	Elsevier; Medline; PMC
abstract	The phenotypic and functional dichotomy between IRF8(+) type 1 and IRF4(+) type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions, when additionally monocyte-derived cells (MCs) become competent antigen-presenting cells (APCs). Using single-cell technologies in models of respiratory viral infection, we found that lung cDC2s acquired expression of the Fc receptor CD64 shared with MCs and of IRF8 shared with cDC1s. These inflammatory cDC2s (inf-cDC2s) were superior in inducing CD4(+) T helper (Th) cell polarization while simultaneously presenting antigen to CD8(+) T cells. When carefully separated from inf-cDC2s, MCs lacked APC function. Inf-cDC2s matured in response to cell-intrinsic Toll-like receptor and type 1 interferon receptor signaling, upregulated an IRF8-dependent maturation module, and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are easily confused with monocyte-derived cells, their existence could explain why APC functions have been attributed to MCs.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2020.04.005
bibo:pmid	32392463
has license	no-cc
sha1sum (hex)	1ef26c8eb838961acae5717bfaee1c13083d4b5b
schema:url	https://doi.org/10.1016/j.immuni.2020.04.005
resource representing a document's title	Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection
has PubMed Central identifier	PMC7207120
has PubMed identifier	32392463
schema:publication	Immunity
resource representing a document's body	covid:1ef26c8eb838961acae5717bfaee1c13083d4b5b#body_text
is schema:about of	named entity 'UNRESTRICTED' named entity 'COVID-19' named entity 'REMAINS' named entity 'resource centre' named entity 'COVID-19' named entity 'Type 2' named entity 'vaccination' named entity 'acute respiratory distress syndrome' named entity 'MAR-1' named entity 'type 1 IFN' named entity 'DCs' named entity 'monocyte' named entity 'IPA' named entity 'CD4 +' named entity 'Clec9a' named entity 'CD45' named entity 'MAR-1' named entity 'ANOVA' named entity 'mRNA' named entity 'Pathway Analysis' named entity 'Tyrosine-protein kinase' named entity 'chemokines' named entity 'Type 1' named entity 'TLR' named entity 'CD26' named entity 'CCR2' named entity 'non-migratory' named entity 'MLNs' named entity 'MAR-1' named entity 'Aibar' named entity 'CD64' named entity 'OVA' named entity 'CD64' named entity 'lungs' named entity 'inflammation' named entity 'immune serum' named entity 'MHCII' named entity 'IFN-g' named entity 'acute lung injury' named entity 'CTV' named entity 'Ifnar1' named entity 'antigen' named entity 'Ifnar1' named entity 'CD45' named entity 'mice' named entity 'lungs' named entity 'DCs' named entity 'CD4 +' named entity 'flow cytometry' named entity 'IRF4' named entity 'MADs' named entity 'intratracheal' named entity 'DCs' named entity 'ARDS' named entity 'CD64' named entity 'mice' named entity 'mice' named entity 'ovalbumin' named entity 'mitochondrial' named entity 'correction for multiple comparisons' named entity 'HDM'

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