About: Oral immunization of cattle with hemagglutinin protein of rinderpest virus expressed in transgenic peanut induces specific immune responses

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About: Oral immunization of cattle with hemagglutinin protein of rinderpest virus expressed in transgenic peanut induces specific immune responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oral immunization of cattle with hemagglutinin protein of rinderpest virus expressed in transgenic peanut induces specific immune responses
Creator	Khandelwal, Abha Lakshmi Sita, G Shaila,
Source	Elsevier; Medline; PMC
abstract	Abstract Rinderpest is an acute, highly contagious often fatal disease of large and small ruminants, both domestic and wild. Global eradication of rinderpest needs a robust, safe and cost-effective vaccine. The causative agent, rinderpest virus (RPV) is an important member of the genus Morbillivirus in the Paramyxoviridae family. We have generated transgenic peanut (Arachis hypogea L.) plants expressing hemagglutinin protein of RPV and report here, the induction of immune responses in cattle following oral feeding with transgenic leaves expressing hemagglutinin protein without oral adjuvant. Hemagglutinin-specific antibody was detected in the serum as confirmed by immunohistochemical staining of virus-infected cells, and in vitro neutralization of virus infectivity. Oral delivery also resulted in cell-mediated immune responses.
has issue date	2003-07-04(xsd:dateTime)
bibo:doi	10.1016/s0264-410x(03)00192-0
bibo:pmid	12804859
has license	els-covid
sha1sum (hex)	1ec8dc2951aa6e1fda625fc43e797123414c775a
schema:url	https://doi.org/10.1016/s0264-410x%2803%2900192-0
resource representing a document's title	Oral immunization of cattle with hemagglutinin protein of rinderpest virus expressed in transgenic peanut induces specific immune responses
has PubMed Central identifier	PMC7126942
has PubMed identifier	12804859
schema:publication	Vaccine
resource representing a document's body	covid:1ec8dc2951aa6e1fda625fc43e797123414c775a#body_text
is schema:about of	named entity 'SPECIFIC' named entity 'robust' named entity 'causative' named entity 'eradication' named entity 'virus' named entity 'Paramyxoviridae' named entity 'ORAL IMMUNIZATION' named entity 'TRANSGENIC' named entity 'FOLLOWING' named entity 'ADJUVANT' named entity 'DETECTED' named entity 'HIGHLY' named entity 'TRANSGENIC' named entity 'VIRUS' named entity 'RINDERPEST VIRUS' named entity 'RUMINANTS' named entity 'GENERATED' named entity 'LEAVES' named entity 'RINDERPEST' named entity 'CONFIRMED BY' named entity 'ACUTE' named entity 'CELLS' named entity 'FEEDING' named entity 'IMMUNE RESPONSES' named entity 'MEDIATED' named entity 'PEANUT' named entity 'HAVE' named entity 'PROTEIN ' named entity 'INFECTED' named entity 'CATTLE' named entity 'MEMBER OF' named entity 'EFFECTIVE' named entity 'SERUM' named entity 'SPECIFIC ANTIBODY' named entity 'PLANTS' named entity 'PROTEIN ' named entity 'IMPORTANT' named entity 'VIRUS INFECTIVITY' named entity 'IN VITRO' named entity 'HEMAGGLUTININ' named entity 'IMMUNE RESPONSES' named entity 'HEMAGGLUTININ' named entity 'EXPRESSED' named entity 'GENUS MORBILLIVIRUS' named entity 'INDUCTION' named entity 'PEANUT' named entity 'CATTLE' named entity 'VACCINE' named entity 'NEEDS' named entity 'PARAMYXOVIRIDAE' named entity 'GLOBAL' named entity 'SMALL' named entity 'FATAL DISEASE' named entity 'RINDERPEST VIRUS' named entity 'CAUSATIVE AGENT' named entity 'REPORT' named entity 'FAMILY' named entity 'IMMUNOHISTOCHEMICAL STAINING' named entity 'ORAL DELIVERY' named entity 'CELL' named entity 'COST' named entity 'WILD' named entity 'DOMESTIC' named entity 'SAFE' named entity 'ROBUST' named entity 'LARGE' named entity 'ERADICATION' named entity 'HERE' named entity 'ORAL' covid:arg/1ec8dc2951aa6e1fda625fc43e797123414c775a named entity 'NEUTRALIZATION' named entity 'transgenic' named entity 'hypogea' named entity 'infectivity' named entity 'Oral' named entity 'rinderpest' named entity 'disease' named entity 'infectivity' named entity 'cell-mediated immune responses'

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