About: Organoids as a Powerful Model for Respiratory Diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Organoids as a Powerful Model for Respiratory Diseases
Creator	Shen, Jun Sun, Xin Li, Yu Chen, Huaiyong Wu, Qi
Source	Medline; PMC
abstract	Insults to the alveoli usually lead to inefficient gas exchange or even respiratory failure, which is difficult to model in animal studies. Over the past decade, stem cell-derived self-organizing three-dimensional organoids have emerged as a new avenue to recapitulate respiratory diseases in a dish. Alveolar organoids have improved our understanding of the mechanisms underlying tissue homeostasis and pathological alterations in alveoli. From this perspective, we review the state-of-the-art technology on establishing alveolar organoids from endogenous lung epithelial stem/progenitor cells or pluripotent stem cells, as well as the use of alveolar organoids for the study of respiratory diseases, including idiopathic pulmonary fibrosis, tuberculosis infection, and respiratory virus infection. We also discuss challenges that need to be overcome for future application of alveolar organoids in individualized medicine.
has issue date	2020-03-11(xsd:dateTime)
bibo:doi	10.1155/2020/5847876
bibo:pmid	32256609
has license	cc-by
sha1sum (hex)	1ea389f8fd5d0f0cdec22330dd9e29c5b7217f61
schema:url	https://doi.org/10.1155/2020/5847876
resource representing a document's title	Organoids as a Powerful Model for Respiratory Diseases
has PubMed Central identifier	PMC7086445
has PubMed identifier	32256609
schema:publication	Stem Cells Int
resource representing a document's body	covid:1ea389f8fd5d0f0cdec22330dd9e29c5b7217f61#body_text
is schema:about of	named entity 'respiratory failure' named entity 'virus' named entity 'respiratory diseases' named entity 'RESPIRATORY DISEASES' named entity 'ORGANOIDS' named entity 'DISCUSS' named entity 'PERSPECTIVE' named entity 'OVERCOME' named entity 'PAST' named entity 'EPITHELIAL' named entity 'REVIEW' named entity 'UNDERSTANDING' named entity 'ALVEOLAR' named entity 'STUDY' named entity 'UNDERLYING' named entity 'ENDOGENOUS' named entity 'DISH' named entity 'RESPIRATORY VIRUS INFECTION' named entity 'CHALLENGES' named entity 'STEM' named entity 'ART' named entity 'ALTERATIONS' named entity 'APPLICATION' named entity 'USUALLY' named entity 'MODEL' named entity 'LEAD' named entity 'DERIVED' named entity 'USE OF' named entity 'STEM CELL' named entity 'OF-' named entity 'CELLS' named entity 'ESTABLISHING' named entity 'ORGANIZING' named entity 'NEW' named entity 'ANIMAL STUDIES' named entity 'PLURIPOTENT STEM CELLS' named entity 'GAS EXCHANGE' named entity 'TECHNOLOGY' named entity 'LUNG' named entity 'INCLUDING' named entity 'PATHOLOGICAL' named entity 'DECADE' named entity 'STATE' named entity 'FUTURE' named entity 'MECHANISMS' named entity 'TUBERCULOSIS INFECTION' named entity 'OUR' named entity 'TISSUE HOMEOSTASIS ' named entity 'RESPIRATORY FAILURE' named entity 'AVENUE' named entity 'MODEL' named entity 'NEED' named entity 'INEFFICIENT' named entity 'IMPROVED' named entity 'SELF' named entity 'RESPIRATORY DISEASES' named entity 'POWERFUL' named entity 'INDIVIDUALIZED MEDICINE' named entity 'THREE-DIMENSIONAL' named entity 'ORGANOIDS' named entity 'IDIOPATHIC PULMONARY FIBROSIS' named entity 'HAVE' named entity 'ALVEOLI' named entity 'DIFFICULT' covid:arg/1ea389f8fd5d0f0cdec22330dd9e29c5b7217f61 named entity 'respiratory diseases' named entity 'gas exchange' named entity 'organoids' named entity 'alveolar' named entity 'stem/progenitor cells' named entity 'alveoli' named entity 'gas exchange' named entity 'Alveolar' named entity 'endogenous' named entity 'three-dimensional' named entity 'respiratory diseases' named entity 'stem cell'

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