About: Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection

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About: Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection
Creator	Goodfellow, Ian Doyle, Nicole Abdul-Wahab, Azimah Emmott, Ed Locker, Nicolas Royall, Elizabeth Roberts, Lisa Morley, Simon
source	Medline; PMC
abstract	Protein synthesis is a tightly controlled process responding to several stimuli, including viral infection. As obligate intracellular parasites, viruses depend on the translation machinery of the host and can manipulate it by affecting the availability and function of specific eukaryotic initiation factors (eIFs). Human norovirus is a member of the Caliciviridae family and is responsible for gastroenteritis outbreaks. Previous studies on feline calicivirus and murine norovirus 1 (MNV1) demonstrated that the viral protein, genome-linked (VPg), acts to direct translation by hijacking the host protein synthesis machinery. Here we report that MNV1 infection modulates the MAPK pathway to activate eIF4E phosphorylation. Our results show that the activation of p38 and Mnk during MNV1 infection is important for MNV1 replication. Furthermore, phosphorylated eIF4E relocates to the polysomes, and this contributes to changes in the translational state of specific host mRNAs. We propose that global translational control of the host by eIF4E phosphorylation is a key component of the host-pathogen interaction.
has issue date	2015-02-20(xsd:dateTime)
bibo:doi	10.1074/jbc.m114.602649
bibo:pmid	25561727
has license	cc-by
sha1sum (hex)	1e1f8ec1fffc3e243c9c5b53baf146f0e7c6ddb0
schema:url	https://doi.org/10.1074/jbc.m114.602649
resource representing a document's title	Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection
has PubMed Central identifier	PMC4335213
has PubMed identifier	25561727
schema:publication	J Biol Chem
resource representing a document's body	covid:1e1f8ec1fffc3e243c9c5b53baf146f0e7c6ddb0#body_text
is schema:about of	named entity 'REPLICATION' named entity 'eIF4E' named entity 'machinery' named entity 'eIF4E' named entity 'Activity' named entity 'HOST' named entity 'QUANTITATIVE PCR' named entity 'ABBREVIATIONS' named entity 'QPCR' named entity 'REGULATING' named entity 'SIGNIFICANCE' named entity 'RESULTS' named entity 'REGULATION' named entity 'MNV' named entity 'ROLE' named entity 'CONTRIBUTE ' named entity 'CRITICAL' named entity 'TCID' named entity 'FCV' named entity 'HOST CELL' named entity '50%' named entity 'EIF4E' named entity 'ACTIVITY' named entity 'TRANSLATIONAL CONTROL' named entity 'RELOCATION' named entity 'PHOSPHORYLATED EIF4E' named entity 'EIF4E' named entity 'RESPONSE TO' named entity 'EIF' named entity 'HPI' named entity 'USED' named entity 'CONCLUSION' named entity 'MURINE NOROVIRUS' named entity 'ITS' named entity 'VPG' named entity 'PLAYS' named entity 'PERSISTENCE' named entity 'VIRAL PATHOGENESIS' named entity 'HOURS' named entity 'TRANSLATIONAL REGULATION' named entity 'MULTIPLICITY' named entity 'EIF4E-BINDING PROTEIN' named entity 'TRANSLATION' named entity 'TISSUE CULTURE' named entity 'POLYSOMES' named entity 'GENOME' named entity 'PHOSPHORYLATION' named entity 'FELINE CALICIVIRUS' named entity 'INFECTION' named entity 'CELLULAR RESPONSE' named entity 'MURINE NOROVIRUS 1' named entity 'CONTROLLING' named entity 'INFECTIOUS DOSE' named entity 'ACTIVATION' named entity 'ACTIVITY' named entity 'PROTEIN TRANSLATION' named entity 'VIRAL PROTEIN' named entity 'INFECTION' named entity 'MACHINERY' covid:arg/1e1f8ec1fffc3e243c9c5b53baf146f0e7c6ddb0 named entity 'infection' named entity 'phosphorylation' named entity 'protein translation' named entity 'controlling' named entity 'abbreviations' named entity 'eIF4G' named entity 'viral titer' named entity 'microRNAs' named entity 'eIF4E' named entity 'virus' named entity 'SDS-PAGE' named entity 'incubation' named entity 'eIF4E' named entity 'p38'

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