About: Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

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About: Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons
Creator	Chan, Jasper Fuk-Woo Jin, Dong-Yan Yuen, Kwok-Yung Chan, Kwok-Hung Tee, Kah-Meng Kok, Kin-Hang Zhu, Zheng Cai, Jian-Piao Yin, Feifei Zhu, Houshun Chik, Cyril Oi, Jessica Tsang, Ling Yip, Yan Zhang, Anna Au-Yeung, Kwok-Him Chan, Chung-Sing Chik, Kenn, Ka-Heng Kwok, Vincent Mak, Wing-Nga Poon, Man
source	PMC
abstract	BACKGROUND: Disseminated or fatal Zika virus (ZIKV) infections were reported in immunosuppressed patients. Existing interferon-signaling/receptor-deficient mouse models may not be suitable for evaluating treatment effects of recombinant interferons. METHODS: We developed a novel mouse model for ZIKV infection by immunosuppressing BALB/c mice with dexamethasone. RESULTS: Dexamethasone-immunosuppressed male mice (6–8 weeks) developed disseminated infection as evidenced by the detection of ZIKV-NS1 protein expression and high viral loads in multiple organs. They had ≥ 10% weight loss and high clinical scores soon after dexamethasone withdrawal (10 dpi), which warranted euthanasia at 12 dpi. Viral loads in blood and most tissues at 5 dpi were significantly higher than those at 12 dpi (P < 0.05). Histological examination revealed prominent inflammatory infiltrates in multiple organs, and CD45 + and CD8 + inflammatory cells were seen in the testis. These findings suggested that clinical deterioration occurred during viral clearance by host immune response. Type I interferon treatments improved clinical outcome of mice (100% vs 0% survival). CONCLUSIONS: Besides virus dissemination, inflammation of various tissues, especially orchitis, may be potential complications of ZIKV infection with significant implications on disease transmission and male fertility. Interferon treatment should be considered in patients at high risks for ZIKV-associated complications when the potential benefits outweigh the side effects of treatment.
has issue date	2016-11-12(xsd:dateTime)
bibo:doi	10.1016/j.ebiom.2016.11.017
bibo:pmid	27884655
has license	cc-by-nc-nd
sha1sum (hex)	1e028783dd3a8a7dca6ee99c21277471571b4e1d
schema:url	https://doi.org/10.1016/j.ebiom.2016.11.017
resource representing a document's title	Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons
has PubMed Central identifier	PMC5161441
has PubMed identifier	27884655
schema:publication	EBioMedicine
resource representing a document's body	covid:1e028783dd3a8a7dca6ee99c21277471571b4e1d#body_text
is schema:about of	named entity 'DEXAMETHASONE' named entity 'RECOMBINANT' named entity 'NS1 PROTEIN' named entity 'SUITABLE' named entity 'DISEASE TRANSMISSION' named entity 'ORCHITIS' named entity 'VIRUS' named entity 'NOVEL' named entity 'OUTCOME' named entity 'IMMUNOSUPPRESSED' named entity 'ASSOCIATED' named entity 'DEXAMETHASONE' named entity 'ZIKA VIRUS' named entity 'INTERFERON' named entity 'TYPE I INTERFERON' named entity 'METHODS' named entity 'DETECTION' named entity 'INFLAMMATION' named entity '0.05' named entity 'PATIENTS' named entity 'MALE' named entity 'DPI' named entity 'INFLAMMATORY' named entity 'SEEN' named entity 'REPORTED' named entity 'COMPLICATIONS' named entity 'ORGANS' named entity 'potential' named entity 'warranted' named entity 'potential' named entity 'Infection' named entity 'Orchitis' named entity 'MICE' named entity 'DEFICIENT' named entity 'IN BLOOD' named entity 'WEIGHT LOSS' named entity 'PROMINENT' named entity 'BENEFITS' named entity 'INCLUDING' named entity 'SURVIVAL' named entity 'CONSIDERED' named entity 'MAY BE' named entity '8 WEEKS' named entity 'MOUSE MODELS' named entity 'HOST IMMUNE RESPONSE' named entity 'TREATMENTS' named entity 'EFFECTS' named entity 'VARIOUS' named entity 'HIGH' named entity 'INFILTRATES' named entity 'INTERFERONS' named entity 'RESULTS' named entity 'SCORES' named entity 'TREATED' named entity 'INFECTION' named entity 'TYPE I INTERFERONS' named entity 'ORCHITIS' named entity 'MULTI-ORGAN INVOLVEMENT' named entity 'IMMUNOSUPPRESSED' named entity 'HISTOLOGICAL EXAMINATION'

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