About: Detection of human rhinoviruses by reverse transcription strand invasion based amplification method (RT-SIBA)

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About: Detection of human rhinoviruses by reverse transcription strand invasion based amplification method (RT-SIBA) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of human rhinoviruses by reverse transcription strand invasion based amplification method (RT-SIBA)
Creator	Pitkäranta, Anne Susi, Petri Eboigbodin, Kevin Elf, Sonja Kainulainen, Veera Korpela, Riitta Mäki, Minna Koskinen, Janne
topic	covid:1de4fa1d2edead95545fa80b36501f2491b94ce5#this
Source	Elsevier; Medline; PMC
abstract	Abstract Background: Rhinovirus (RV), a major cause of respiratory infection in humans, imposes an enormous economic burden due to the direct and indirect costs associated with the illness. Accurate and timely diagnosis is crucial for deciding the appropriate clinical approach and minimizing unnecessary prescription of antibiotics. Diagnosis of RV is extremely challenging due to genetic and serological variability among its numerous types and their similarity to enteroviruses. Objective: We sought to develop a rapid nucleic acid test that can be used for the detection of Rhinovirus within both laboratory and near patient settings. Study design: We developed and evaluated a novel isothermal nucleic acid amplification method called Reverse Transcription Strand Invasion-Based Amplification (RT-SIBA) to rapidly detect Rhinovirus from clinical specimens. Result: The method, RT-SIBA, detected RV in clinical specimens with high analytical sensitivity (96%) and specificity (100%). The time to positive result was significantly shorter for the RV RT-SIBA assay than for a reference RV nucleic acid amplification method (RT-qPCR). Conclusion: The rapid detection time of the RV SIBA assay, as well as its compatibility with portable instruments, will facilitate prompt diagnosis of infection and thereby improve patient care.
has issue date	2019-01-31(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2018.10.015
bibo:pmid	30347198
has license	els-covid
sha1sum (hex)	1de4fa1d2edead95545fa80b36501f2491b94ce5
schema:url	https://doi.org/10.1016/j.jviromet.2018.10.015
resource representing a document's title	Detection of human rhinoviruses by reverse transcription strand invasion based amplification method (RT-SIBA)
has PubMed Central identifier	PMC7113843
has PubMed identifier	30347198
schema:publication	Journal of Virological Methods
resource representing a document's body	covid:1de4fa1d2edead95545fa80b36501f2491b94ce5#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/1de4fa1d2edead95545fa80b36501f2491b94ce5
is schema:about of	named entity 'STRAND INVASION' named entity 'DETECTION' named entity 'APPROACH' named entity 'GENETIC' named entity 'DIRECT' named entity 'SEROLOGICAL' named entity 'SIMILARITY' named entity 'ILLNESS' named entity 'VARIABILITY' named entity 'DUE TO' named entity 'RHINOVIRUS' named entity 'ANTIBIOTICS' named entity 'PRESCRIPTION OF' named entity 'TYPES' named entity 'EXTREMELY' named entity 'RHINOVIRUSES' named entity 'BASED' covid:arg/1de4fa1d2edead95545fa80b36501f2491b94ce5 named entity 'METHOD' named entity 'INDIRECT COSTS' named entity 'ECONOMIC BURDEN' named entity 'THEIR' named entity 'NUMEROUS' named entity 'CLINICAL' named entity 'HUMANS' named entity 'ACCURATE' named entity 'DECIDING' named entity 'SIBA' named entity 'AMPLIFICATION' named entity 'ITS' named entity 'CAUSE' named entity 'A MAJOR' named entity 'RESPIRATORY INFECTION' named entity 'APPROPRIATE' named entity 'HUMAN' named entity 'TIMELY' named entity 'ASSOCIATED WITH' named entity 'BACKGROUND' named entity 'REVERSE TRANSCRIPTION' named entity 'ENTEROVIRUSES' named entity 'DIAGNOSIS' named entity 'diagnosis' named entity 'Detection' named entity 'enteroviruses' named entity 'respiratory infection' named entity 'reverse transcription' named entity 'RV-C' named entity 'Eurofins' named entity 'magnesium acetate' named entity 'rhinovirus' named entity 'viruses' named entity 'sensitivity and specificity' named entity 'reverse transcriptase' named entity 'cloned' named entity 'RT-PCR' named entity 'protein' named entity 'genus' named entity 'asthma' named entity 'RNA' named entity 'genome' named entity 'oligonucleotides' named entity 'RT-PCR' named entity 'oligonucleotides' named entity 'RNA' named entity 'viruses' named entity 'RNA' named entity 'SYBR Green 1' named entity 'virus' named entity 'microbial' named entity 'epithelia' named entity 'plasmids' named entity 'RV-C'

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