About: Dissecting host cell death programs in the pathogenesis of influenza

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dissecting host cell death programs in the pathogenesis of influenza
Creator	Coulombe, François Divangahi, Maziar Downey, Jeffrey Pernet, Erwan
Source	Elsevier; Medline; PMC
abstract	Influenza A virus (IAV) is a pulmonary pathogen, responsible for significant yearly morbidity and mortality. Due to the absence of highly effective antiviral therapies and vaccine, as well as the constant threat of an emerging pandemic strain, there is considerable need to better understand the host–pathogen interactions and the factors that dictate a protective versus detrimental immune response to IAV. Even though evidence of IAV-induced cell death in human pulmonary epithelial and immune cells has been observed for almost a century, very little is known about the consequences of cell death on viral pathogenesis. Recent study indicates that both the type of cell death program and its kinetics have major implications on host defense and survival. In this review, we discuss advances in our understanding of cell death programs during influenza virus infection, in hopes of fostering new areas of investigation for targeted clinical intervention.
has issue date	2018-04-18(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2018.03.005
bibo:pmid	29679740
has license	no-cc
sha1sum (hex)	1d6839a8ec865e914bfc4e4fec44f8bc9f493ebb
schema:url	https://doi.org/10.1016/j.micinf.2018.03.005
resource representing a document's title	Dissecting host cell death programs in the pathogenesis of influenza
has PubMed Central identifier	PMC7110448
has PubMed identifier	29679740
schema:publication	Microbes Infect
resource representing a document's body	covid:1d6839a8ec865e914bfc4e4fec44f8bc9f493ebb#body_text
is schema:about of	named entity 'CELL DEATH' named entity 'cell death' named entity 'immune response' named entity 'IAV' named entity 'HIGHLY' named entity 'MORBIDITY AND MORTALITY' named entity 'RECENT' named entity 'INFLUENZA A VIRUS' named entity 'DISCUSS' named entity 'RESPONSIBLE' named entity 'VACCINE' named entity 'RESPONSE TO' named entity 'CENTURY' named entity 'PROGRAM' named entity 'IMMUNE CELLS' named entity 'OUR' named entity 'HAVE' named entity 'PROGRAMS' named entity 'KINETICS' named entity 'SIGNIFICANT' named entity 'CONSEQUENCES' named entity 'EPITHELIAL' named entity 'HOST DEFENSE' named entity 'PULMONARY' named entity 'SURVIVAL' named entity 'INFLUENZA VIRUS' named entity 'UNDERSTANDING' named entity 'INVESTIGATION' named entity 'HOPES' named entity 'TYPE OF CELL' named entity 'CONSTANT' named entity 'MAJOR' named entity 'VIRUS INFECTION' named entity 'THREAT' named entity 'VERY LITTLE' named entity 'REVIEW' named entity 'YEARLY' named entity 'BETTER' named entity 'ANTIVIRAL' named entity 'STUDY' named entity 'HUMAN' named entity 'NEW' named entity 'INDUCED' named entity 'IS A' named entity 'UNDERSTAND' named entity 'FOSTERING' named entity 'KNOWN' named entity 'PROGRAMS' named entity 'PATHOGENESIS' named entity 'VIRAL PATHOGENESIS' named entity 'ABOUT' named entity 'OBSERVED' named entity 'PATHOGEN' named entity 'CLINICAL INTERVENTION' named entity 'DUE TO' named entity 'EVIDENCE OF' named entity 'THERAPIES' named entity 'AREAS' named entity 'EFFECTIVE' named entity 'STRAIN' named entity 'ALMOST' named entity 'IMMUNE RESPONSE' named entity 'ABSENCE OF' named entity 'CONSIDERABLE' named entity 'NEED' named entity 'PANDEMIC' named entity 'CELL DEATH' named entity 'TARGETED' named entity 'INFLUENZA' named entity 'DISSECTING' named entity 'HOST CELL' named entity 'ITS' named entity 'INTERACTIONS' named entity 'antiviral' named entity 'factors' named entity 'cell death' named entity 'hopes' named entity 'targeted'

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