About: Molecular Mimicry in Multiple Sclerosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Mimicry in Multiple Sclerosis
Creator	Fujinami, Robert Libbey, Jane Mccoy, Lori
Source	Elsevier; Medline; PMC
abstract	One of the most common demyelinating central nervous system (CNS) diseases in humans is multiple sclerosis (MS). The disease can be very debilitating with vision loss, motor and sensory disturbances, and cognitive impairment. The clinical course may present as a relapsing‐remitting disease course, a progressive disease course, or a combination thereof. The etiology of MS is unknown. Though many viruses have been shown to be associated with MS, no one virus has ever been demonstrated to be the cause of MS. In addition, MS is thought to have an autoimmune component. Molecular mimicry is one hypothesis put forth which could reconcile the diverse pathology and etiology of MS. Molecular mimicry occurs when peptides from pathogens share sequence or structural similarities with self‐antigens. Infection with various pathogens, each with its individual molecular mimic to a CNS antigen, may explain the inability of investigators to link one specific virus to MS. Molecular mimicry may be mediated through human leukocyte antigen class I‐ and class II‐restricted T cells and antibodies, which may explain the diversity in phenotype. Aspects of molecular mimicry will be discussed in relation to each of these immune system components. Examples of various molecular mimics will be discussed with a particular focus on the CNS and MS. Molecular mimicry alone may not be able to induce disease; priming of the immune system by infection with a pathogen that carries a molecular mimic to self may have to be followed by a later nonspecific immunologic challenge in order for disease to be initiated. Recent research into this priming and triggering of disease will be discussed in relation to an animal model for MS.
has issue date	2007-12-31(xsd:dateTime)
bibo:doi	10.1016/s0074-7742(07)79006-2
bibo:pmid	17531840
has license	els-covid
sha1sum (hex)	1d5f1ba26f1c1c7d7668715849f7bd1b296bf7f3
schema:url	https://doi.org/10.1016/s0074-7742%2807%2979006-2
resource representing a document's title	Molecular Mimicry in Multiple Sclerosis
has PubMed Central identifier	PMC7127675
has PubMed identifier	17531840
schema:publication	International Review of Neurobiology
resource representing a document's body	covid:1d5f1ba26f1c1c7d7668715849f7bd1b296bf7f3#body_text
is schema:about of	named entity 'MOLECULAR MIMICRY' named entity 'MULTIPLE SCLEROSIS' named entity 'MOLECULAR MIMICRY' named entity 'adoptive transfer' named entity 'nonpathogenic' named entity 'virus' named entity 'clones' named entity 'EBV' named entity 'exanthem' named entity 'autoimmune diseases' named entity 'MBP' named entity 'viruses' named entity 'mice' named entity 'cytomegalovirus' named entity 'HSV-1' named entity 'CD8' named entity 'infection' named entity 'systemic lupus erythematosus' named entity 'LCMV' named entity 'mice' named entity 'autoimmune diseases' named entity 'TMEV' named entity 'TCR' named entity 'T-cell' named entity 'CD4' named entity 'HTLV-1' named entity 'viral protein' named entity 'EBV' named entity 'MBP' named entity 'DNA polymerase' named entity 'spinal cord' named entity 'LCMV' named entity 'CNS' named entity 'immunosuppression' named entity 'CSF' named entity 'EBV' named entity 'mouse brain' named entity 'lymphocytes' named entity 'DNA studies' named entity 'autoimmune diseases' named entity 'CNS' named entity 'autoimmune disease' named entity 'risk factors' named entity 'infection' named entity 'MBP' named entity 'TCR' named entity 'antigen' named entity 'clinical disease' named entity 'infection' named entity 'EBV' named entity 'CD8' named entity 'Lymphocytic choriomeningitis virus' named entity 'neurological diseases' named entity 'mimotope' named entity 'antigen' named entity 'positively charged' named entity 'myelin oligodendrocyte glycoprotein' named entity 'pathology' named entity '4-carboxymuconolactone decarboxylase' named entity 'immunodominance' named entity 'molecular mimicry' named entity 'influenza-A' named entity 'sequence similarity' named entity 'antibodies' named entity 'peptides' named entity 'negative control' named entity 'IL-10' named entity 'LCMV' named entity 'TCR' named entity 'mice' named entity 'immunodominant' named entity 'peptides' named entity 'Molecular mimicry' named entity 'neuroinflammation' named entity 'transgenic mice' named entity 'ganglioside' named entity 'T-cell' named entity 'allogeneic' named entity 'cellular immune response'

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