About: Nociceptor sensory neurons suppress neutrophil and ᵞδ T cell responses in bacterial lung infections and lethal pneumonia

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About: Nociceptor sensory neurons suppress neutrophil and ᵞδ T cell responses in bacterial lung infections and lethal pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nociceptor sensory neurons suppress neutrophil and ᵞδ T cell responses in bacterial lung infections and lethal pneumonia
Creator	Zhou, Yan Li, Lu Baral, Pankaj Bist, Meghna Kirschbaum, Talia Wallrapp, Antonia Wei, Yibing Burkett, Patrick Chiu, Isaac Kuchroo, Vijay Liberles, Stephen Umans, Benjamin Yipp, Bryan
Source	Medline; PMC
abstract	Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and consequently protect organisms by mediating coughing, pain, and bronchoconstriction. However, the role of sensory neurons in pulmonary host defense is unclear. Here, we found that TRPV1(+) nociceptors suppressed protective immunity against lethal Staphylococcus aureus pneumonia. Targeted TRPV1(+)-neuron ablation increased survival, cytokine induction, and lung bacterial clearance. Nociceptors suppressed the recruitment and surveillance of neutrophils, and altered lung ᵞδ T cell numbers, which are necessary for immunity. Vagal ganglia TRPV1(+) afferents mediated immunosuppression through release of the neuropeptide calcitonin gene–related peptide (CGRP). Targeting neuroimmunological signaling may be an effective approach to treat lung infections and bacterial pneumonia.
has issue date	2018-03-05(xsd:dateTime)
bibo:doi	10.1038/nm.4501
bibo:pmid	29505031
has license	green-oa
sha1sum (hex)	1cbfbf23583e6cc52947575946249368624f0e28
schema:url	https://doi.org/10.1038/nm.4501
resource representing a document's title	Nociceptor sensory neurons suppress neutrophil and ᵞδ T cell responses in bacterial lung infections and lethal pneumonia
has PubMed Central identifier	PMC6263165
has PubMed identifier	29505031
schema:publication	Nature Medicine
resource representing a document's body	covid:1cbfbf23583e6cc52947575946249368624f0e28#body_text
is schema:about of	covid:arg/1cbfbf23583e6cc52947575946249368624f0e28 named entity 'bronchoconstriction' named entity 'ganglia' named entity 'sensory neurons' named entity 'TRPV1' named entity 'immunosuppression' named entity 'Nociceptors' named entity 'neutrophils' named entity 'lung infections' named entity 'neuron' named entity 'host defense' named entity 'lung infections' named entity 'Nociceptor' named entity 'PBS' named entity 'neurons' named entity 'inflammation' named entity 'neutrophils' named entity 'Gram-positive bacteria' named entity 'host defenses' named entity 'neuron' named entity 'TRPV1' named entity 'Alexa Fluor' named entity 'bacteria' named entity 'noxious stimuli' named entity 'inflammation' named entity 'euthanized' named entity 'BALF' named entity 'liposomes' named entity 'Trpv1' named entity 'TRPV1' named entity 'CGRP' named entity 'yeast extract' named entity 'CXCL1' named entity 'CD4' named entity 'diphtheria toxin' named entity 'subcutaneously' named entity 'lateral decubitus' named entity 'supernatant' named entity 'serotype' named entity 'cytokine' named entity 'laminin' named entity 'TRPV1' named entity 'respiratory tract' named entity 'core body temperature' named entity 'MRSA' named entity 'transcriptional' named entity 'K. pneumoniae' named entity 'PBS' named entity 'core body temperature' named entity 'subcutaneously' named entity 'IL-17A' named entity 'γδ T cells' named entity 'S. aureus' named entity 'immune cells' named entity 'immune cells' named entity 'Adhesion' named entity 'survival studies' named entity 'microscope' named entity 'FITC' named entity 'neurons' named entity 'infection' named entity 'pneumonia' named entity 'lung infections' named entity 'S. aureus' named entity 'homogenized' named entity 'CGRP' named entity 'alveolar macrophages' named entity 'clone' named entity 'CD11b'

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