About: Recombinant influenza H9N2 virus with a substitution of H3 hemagglutinin transmembrane domain showed enhanced immunogenicity in mice and chicken

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About: Recombinant influenza H9N2 virus with a substitution of H3 hemagglutinin transmembrane domain showed enhanced immunogenicity in mice and chicken Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Recombinant influenza H9N2 virus with a substitution of H3 hemagglutinin transmembrane domain showed enhanced immunogenicity in mice and chicken
Creator	Cao, Yongchang Xue, Chunyi Wang, Yang Li, Ran Zhang, Yun Huang, Mengjiao Liu, Qiliang Liu, Kang Wei, Ying Zheng, Jing
topic	covid:1c39727d1bf8a4e67e43fccecf8dafcd9b960b70#this
Source	PMC
abstract	In recent years, avian influenza virus H9N2 undergoing antigenic drift represents a threat to poultry farming as well as public health. Current vaccines are restricted to inactivated vaccine strains and their related variants. In this study, a recombinant H9N2 (H9N2-TM) strain with a replaced H3 hemagglutinin (HA) transmembrane (TM) domain was generated. Virus assembly and viral protein composition were not affected by the transmembrane domain replacement. Further, the recombinant TM-replaced H9N2-TM virus could provide better inter-clade protection in both mice and chickens against H9N2, suggesting that the H3-TM-replacement could be considered as a strategy to develop efficient subtype-specific H9N2 influenza vaccines.
has issue date	2017-12-20(xsd:dateTime)
bibo:doi	10.1038/s41598-017-18054-x
bibo:pmid	29263359
has license	cc-by
sha1sum (hex)	1c39727d1bf8a4e67e43fccecf8dafcd9b960b70
schema:url	https://doi.org/10.1038/s41598-017-18054-x
resource representing a document's title	Recombinant influenza H9N2 virus with a substitution of H3 hemagglutinin transmembrane domain showed enhanced immunogenicity in mice and chicken
has PubMed Central identifier	PMC5738434
has PubMed identifier	29263359
schema:publication	Sci Rep
resource representing a document's body	covid:1c39727d1bf8a4e67e43fccecf8dafcd9b960b70#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/1c39727d1bf8a4e67e43fccecf8dafcd9b960b70
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