About: Distinctive clinical features of human bocavirus in children younger than 2 years

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Distinctive clinical features of human bocavirus in children younger than 2 years
Creator	Maeda, Yasuhiro Okada, M Hamada, Hiromichi Hayashi, Kitami Hirose, Yosuke Honda, Takafumi Maru, Hiromi Moriyama, Yoko Muto, Ayako Okada, Mineyuki Omura, Yoh Shirato, Yuri Terai, Masaru Tsuchiya, Nozomi Yoshida, Masaki Yoshida, M Hamada, H Hayashi, : Hirose, Y Honda, T Maeda, Y Maru, : Moriyama, Y Muto, : Omura, Y Shirato, Y Terai, M Tsuchiya, N
Source	Medline; PMC
abstract	BACKGROUND AND OBJECTIVE: Clinical characteristics of human bocavirus (HBoV) infection have been studied worldwide, but their importance of those characteristics remains unknown. We investigated distinctive clinical features of HBoV-positive children with lower respiratory tract infection (LRTI). METHODS AND RESULTS: During April 2007–July 2009, for 402 hospitalized children younger than 2 years with LRTI, we prospectively examined virus genomes in nasopharyngeal swabs for HBoV, respiratory syncytial virus (RSV), rhinovirus, metapneumovirus, parainfluenzavirus, and adenovirus. The HBoV genomes were identified in 34 patients (8.5%). Clinical and laboratory data of HBoV-positive and other virus/bacteria-negative patients (n = 18) were analyzed and compared with data of RSV-single positive patients (n = 99). The seasonal distribution of HBoV exhibits a concentration of cases during March–September, with most RSV cases occurring during winter in Japan. The minimum age of HBoV-positive patients was 5 months, although 44 patients (44%) with RSV were younger than 6 months. The main clinical features were respiratory distress and hypoxia. Hypoxia advances within 3 days after onset. The mean oxygen saturation on arrival was 92.8%, which was significantly lower than that in patients with RSV (p < 0.001). White blood cell counts were similar among groups. However, the percentage of neutrophils in white blood cells were significantly higher in HBoV-positive patients (62 vs. 45%, p < 0.001). Their prognoses were good. Their hospital stays were 6.6 days. CONCLUSIONS: HBoV-single positive patients show several clinical characteristics, such as seasonality, age, hypoxia, and neutrophilia, which differ from those with RSV infection.
has issue date	2010-04-10(xsd:dateTime)
bibo:doi	10.1007/s00431-010-1183-x
bibo:pmid	20383526
has license	cc-by-nc
sha1sum (hex)	1c38d6ab050242d8a1552846481949dc6aa75690
schema:url	https://doi.org/10.1007/s00431-010-1183-x
resource representing a document's title	Distinctive clinical features of human bocavirus in children younger than 2 years
has PubMed Central identifier	PMC2908446
has PubMed identifier	20383526
schema:publication	Eur J Pediatr
resource representing a document's body	covid:1c38d6ab050242d8a1552846481949dc6aa75690#body_text
is schema:about of	named entity 'infection' named entity 'remains' named entity 'cases' named entity 'patients' named entity 'patients' named entity 'patients' named entity 'CLINICAL FEATURES' covid:arg/1c38d6ab050242d8a1552846481949dc6aa75690 named entity 'RSV INFECTION' named entity 'CONCENTRATION OF' named entity 'APRIL' named entity '0.001' named entity 'MEAN' named entity 'PROGNOSES' named entity 'HOSPITAL' named entity 'CLINICAL CHARACTERISTICS' named entity 'MARCH' named entity 'CHARACTERISTICS' named entity 'INVESTIGATED' named entity 'DISTRIBUTION' named entity 'SEPTEMBER' named entity 'CLINICAL' named entity 'HIGHER' named entity 'YEARS' named entity '6.6' named entity 'MONTHS' named entity 'METHODS' named entity 'SINGLE' named entity 'SWABS' named entity 'YOUNGER' named entity 'DAYS' named entity 'LRTI' named entity 'OBJECTIVE' named entity 'NEUTROPHILS' named entity 'LOWER' named entity 'YOUNGER' named entity 'HUMAN BOCAVIRUS' named entity 'CHILDREN' named entity 'YEARS' named entity 'NEGATIVE' named entity 'JAPAN' named entity 'HAVE' named entity 'ARRIVAL' named entity 'HYPOXIA' named entity 'VIRUS' named entity 'MAIN' named entity 'METAPNEUMOVIRUS' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'BUT' named entity 'PERCENTAGE' named entity 'GROUPS' named entity 'ADENOVIRUS' named entity '28P' named entity 'PATIENTS'

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