About: ACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous Pleural Effusions

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About: ACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous Pleural Effusions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous Pleural Effusions
Creator	Chen, Mu-Yuan Cheng, Kun-Shan Hsieh, Wen-Yeh Hsu, Wei-Hua Hsu, Yuan-Chang Huang, Chen-Yi Kuan, Tang-Ching Liao, Yan-Chiou Lin, Chih-Sheng Lin, Pei-Heng Yu, Sheng-Yao
Source	Medline; PMC
abstract	Objective: Pleural effusion is common problem, but the rapid and reliable diagnosis for specific pathogenic effusions are lacking. This study aimed to identify the diagnosis based on clinical variables to differentiate pleural tuberculous exudates from other pleural effusions. We also investigated the role of renin-angiotensin system (RAS) and matrix metalloproteinase (MMPs) in the pathogenesis of pleural exudates. Experimental design: The major components in RAS and extracellular matrix metabolism, including angiotensin converting enzyme (ACE), ACE2, MMP-2 and MMP-9 activities, were measured and compared in the patients with transudative (n = 45) and exudative (n = 80) effusions. The exudative effusions were come from the patients with tuberculosis (n = 20), pneumonia (n = 32), and adenocarcinoma (n = 28). Results: Increased ACE and equivalent ACE2 activities, resulting in a significantly increased ACE/ACE2 ratio in exudates, were detected compared to these values in transudates. MMP-9 activity in exudates was significantly higher than that in transudates. The significant correlation between ACE and ACE2 activity that was found in transudates was not found in exudates. Advanced analyses showed significantly increased ACE and MMP-9 activities, and decreased ACE2 activity in tuberculous pleural effusions compared with those in pneumonia and adenocarcinoma effusions. The results indicate that increased ACE and MMP-9 activities found in the exudates were mainly contributed from a higher level of both enzyme activities in the tuberculous pleural effusions. Conclusion: Interplay between ACE and ACE2, essential functions in the RAS, and abnormal regulation of MMP-9 probably play a pivotal role in the development of exudative effusions. Moreover, the ACE/ACE2 ratio combined with MMP-9 activity in pleural fluid may be potential biomarkers for diagnosing tuberculous pleurisy.
has issue date	2012-10-17(xsd:dateTime)
bibo:doi	10.7150/ijbs.5087
bibo:pmid	23091417
has license	cc-by-nc-nd
sha1sum (hex)	1b58422e266ab9339c919119923229d080f27360
schema:url	https://doi.org/10.7150/ijbs.5087
resource representing a document's title	ACE/ACE2 Ratio and MMP-9 Activity as Potential Biomarkers in Tuberculous Pleural Effusions
has PubMed Central identifier	PMC3477689
has PubMed identifier	23091417
schema:publication	Int J Biol Sci
resource representing a document's body	covid:1b58422e266ab9339c919119923229d080f27360#body_text
is schema:about of	named entity 'ABNORMAL' named entity '80%' named entity 'PROBABLY' named entity 'REGULATION' named entity 'MATRIX METALLOPROTEINASE' named entity 'RAS' named entity 'BASED' named entity 'ACE' named entity 'LEVEL' named entity 'PATIENTS' named entity 'COMPONENTS' named entity 'ACE2' named entity 'FOUND' named entity 'RATIO' named entity 'ACTIVITY' named entity 'EXTRACELLULAR MATRIX' named entity 'SPECIFIC' named entity 'STUDY' named entity 'MAJOR' named entity 'DEVELOPMENT' named entity 'NOT FOUND' named entity 'VALUES' named entity 'PLAY' named entity 'PATHOGENIC' named entity 'EQUIVALENT' named entity 'common' named entity 'ACE2' named entity 'potential' named entity 'MMP-9' named entity 'ACE2' named entity 'compared' named entity 'investigated' named entity 'MMP-9' named entity 'ACE' named entity 'PLEURAL EFFUSIONS' named entity 'TUBERCULOSIS' named entity 'CONCLUSION' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'SIGNIFICANT' named entity 'EXUDATES' named entity 'PNEUMONIA' named entity 'CLINICAL' named entity 'RAPID' named entity 'POTENTIAL' named entity 'LACKING' named entity 'INCREASED' named entity 'THESE' named entity 'VARIABLES' named entity 'TO IDENTIFY' named entity 'RATIO' named entity 'ACTIVITY' named entity 'BIOMARKERS' named entity 'TUBERCULOUS' named entity 'ACE' named entity 'MMP-9' named entity 'ENZYME' named entity 'MMP-2' named entity 'PATHOGENESIS' named entity 'BIOMARKERS' named entity 'INVESTIGATED' named entity 'EFFUSIONS' named entity 'MMP-9' named entity 'PLEURAL EFFUSIONS' named entity 'EXPERIMENTAL DESIGN' named entity 'INCLUDING' named entity 'COME' named entity 'RESULTS' named entity 'OBJECTIVE' named entity 'RELIABLE' named entity 'ADENOCARCINOMA' named entity 'ESSENTIAL'

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