About: Diversity of Dromedary Camel Coronavirus HKU23 in African Camels Revealed Multiple Recombination Events among Closely Related Betacoronaviruses of the Subgenus Embecovirus

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About: Diversity of Dromedary Camel Coronavirus HKU23 in African Camels Revealed Multiple Recombination Events among Closely Related Betacoronaviruses of the Subgenus Embecovirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Diversity of Dromedary Camel Coronavirus HKU23 in African Camels Revealed Multiple Recombination Events among Closely Related Betacoronaviruses of the Subgenus Embecovirus
Creator	Peiris, Malik Poon, Leo Miguel, Eve Roger, François Chevalier, Veronique Zhou, Ziqi Fassi-Fihri, Ouafaa Chu, Daniel Webby, Richard Perera, Ranawaka Woo, Patrick Oladipo, Jamiu So, Ray Ko, Ronald Kuranga, Sulyman Aylet, Gelagay Cheng, Mo-Sheung
source	Medline; PMC
abstract	Genetic recombination has frequently been observed in coronaviruses. Here, we sequenced multiple complete genomes of dromedary camel coronavirus HKU23 (DcCoV-HKU23) from Nigeria, Morocco, and Ethiopia and identified several genomic positions indicative of cross-species virus recombination events among other betacoronaviruses of the subgenus Embecovirus (clade A beta-CoVs). Recombinant fragments of a rabbit coronavirus (RbCoV-HKU14) were identified at the hemagglutinin esterase gene position. Homolog fragments of a rodent CoV were also observed at 8.9-kDa open reading frame 4a at the 3′ end of the spike gene. The patterns of recombination differed geographically across the African region, highlighting a mosaic structure of DcCoV-HKU23 genomes circulating in dromedaries. Our results highlighted active recombination of coronaviruses circulating in dromedaries and are also relevant to the emergence and evolution of other betacoronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV). IMPORTANCE Genetic recombination is often demonstrated in coronaviruses and can result in host range expansion or alteration in tissue tropism. Here, we showed interspecies events of recombination of an endemic dromedary camel coronavirus, HKU23, with other clade A betacoronaviruses. Our results supported the possibility that the zoonotic pathogen MERS-CoV, which also cocirculates in the same camel species, may have undergone similar recombination events facilitating its emergence or may do so in its future evolution.
has issue date	2019-11-13(xsd:dateTime)
bibo:doi	10.1128/jvi.01236-19
bibo:pmid	31534035
has license	no-cc
sha1sum (hex)	1af37332a222bf25be7bf1740f483aa8ceabaa2e
schema:url	https://doi.org/10.1128/jvi.01236-19
resource representing a document's title	Diversity of Dromedary Camel Coronavirus HKU23 in African Camels Revealed Multiple Recombination Events among Closely Related Betacoronaviruses of the Subgenus Embecovirus
has PubMed Central identifier	PMC6854494
has PubMed identifier	31534035
schema:publication	J Virol
resource representing a document's body	covid:1af37332a222bf25be7bf1740f483aa8ceabaa2e#body_text
is schema:about of	named entity 'Embecovirus' named entity 'Nigeria' named entity 'circulating' named entity 'active' named entity 'events' named entity 'highlighting' named entity 'Revealed' named entity 'Multiple' covid:arg/1af37332a222bf25be7bf1740f483aa8ceabaa2e named entity 'sequenced' named entity 'Middle East respiratory syndrome' named entity 'recombination' named entity 'genomic' named entity 'betacoronaviruses' named entity 'fragments' named entity 'gene' named entity 'frequently' named entity 'recombination' named entity 'coronaviruses' named entity 'fragments' named entity 'Embecovirus' named entity 'recombination events' named entity 'dromedaries' named entity 'rodent' named entity 'sequenced' named entity 'genomes' named entity 'betacoronaviruses' named entity 'Nigeria' named entity 'evolution' named entity 'betacoronaviruses' named entity 'Betacoronaviruses' named entity 'Coronavirus' named entity 'spike' named entity 'homologous recombination' named entity 'primers' named entity 'intermediate hosts' named entity 'Ethiopia' named entity 'dromedary camels' named entity 'genomes' named entity 'BCoV' named entity 'giraffe' named entity 'virus' named entity 'nucleocapsid' named entity 'epidemic' named entity 'coronaviruses' named entity 'gene' named entity 'encephalomyelitis' named entity 'open reading frame' named entity 'copy number' named entity 'RNA' named entity 'endemic' named entity 'Phylogenetic analysis' named entity 'MERS-CoV' named entity 'Severe acute respiratory syndrome' named entity 'genotypes' named entity 'coronaviruses' named entity 'MHV' named entity 'dromedary camels' named entity 'dromedary' named entity 'virus' named entity 'recombination' named entity 'nonstructural protein' named entity 'BCoV' named entity 'clade' named entity 'tropism'

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