About: Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection

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About: Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection
Creator	Paessler, Slobodan Frolov, Ilya Dziuba, Natallia Yun, Nadezhda Judy, Barbara Weaver, Scott Campbell, Gerald Estes, D Grund, Anna Zacks, Michele
source	Elsevier; Medline; PMC
abstract	We evaluated the safety and immunogenicity of a chimeric alphavirus vaccine candidate in mice with selective immunodeficiencies. This vaccine candidate was highly attenuated in mice with deficiencies in the B and T cell compartments, as well as in mice with deficient gamma-interferon responsiveness. However, the level of protection varied among the strains tested. Wild type mice were protected against lethal VEEV challenge. In contrast, alpha/beta (αβ) TCR-deficient mice developed lethal encephalitis following VEEV challenge, while mice deficient in gamma/delta ( γδ) T cells were protected. Surprisingly, the vaccine potency was diminished by 50% in animals lacking interferon-gamma receptor alpha chain (R1)-chain and a minority of vaccinated immunoglobulin heavy chain-deficient (μMT) mice survived challenge, which suggests that neutralizing antibody may not be absolutely required for protection. Prolonged replication of encephalitic VEEV in the brain of pre-immunized mice is not lethal and adoptive transfer experiments indicate that CD3(+) T cells are required for protection.
has issue date	2007-10-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2007.05.041
bibo:pmid	17610927
has license	green-oa
sha1sum (hex)	1a9597a57cd6c3255a954c3a466dc211f5673382
schema:url	https://doi.org/10.1016/j.virol.2007.05.041
resource representing a document's title	Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection
has PubMed Central identifier	PMC2067255
has PubMed identifier	17610927
schema:publication	Virology
resource representing a document's body	covid:1a9597a57cd6c3255a954c3a466dc211f5673382#body_text
is schema:about of	named entity 'PROVIDE' named entity 'mice' named entity 'ANIMALS' named entity 'ADOPTIVE TRANSFER' named entity 'VEEV' named entity 'VACCINE CANDIDATE' named entity 'LETHAL' named entity 'VACCINE POTENCY' named entity 'MICE' named entity 'ENCEPHALITIS' named entity 'VACCINATED' named entity 'EVALUATED' named entity 'LACKING' covid:arg/1a9597a57cd6c3255a954c3a466dc211f5673382 named entity 'TCR' named entity 'INTERFERON-GAMMA RECEPTOR ALPHA CHAIN' named entity 'IMMUNIZED' named entity 'WILD TYPE' named entity 'EXPERIMENTS' named entity 'ALPHA' named entity 'IMMUNOGENICITY' named entity 'CD3' named entity 'PRE' named entity 'DIMINISHED' named entity 'IMMUNOGLOBULIN HEAVY CHAIN' named entity 'MINORITY' named entity 'LEVEL' named entity 'TESTED' named entity 'HIGHLY' named entity 'GAMMA' named entity '50%' named entity 'ENCEPHALITIS' named entity 'MURINE' named entity 'INFECTION' named entity 'LETHAL' named entity 'ALPHA-BETA' named entity 'MODEL OF' named entity 'VEEV' named entity 'T CELLS' named entity 'T CELLS' named entity 'DEFICIENT' named entity 'ATTENUATED' named entity 'PROTECTION' named entity 'SELECTIVE' named entity 'ALPHAVIRUS' named entity 'GAMMA-INTERFERON' named entity 'CHIMERIC' named entity 'T CELL' named entity 'CONTRAST' named entity 'INTERFERON ' named entity 'PROTECTION' named entity 'REPLICATION' named entity 'NEUTRALIZING ANTIBODY' named entity 'COMPARTMENTS' named entity 'STRAINS' named entity 'REQUIRED' named entity 'SAFETY' named entity 'THE BRAIN' named entity 'FOLLOWING' named entity 'RESPONSIVENESS' named entity 'PROLONGED' named entity 'CHALLENGE' named entity 'CHAIN' named entity 'IMMUNODEFICIENCIES' named entity 'developed' named entity 'chain' named entity 'responsiveness' named entity 'strains' named entity 'mice' named entity 'mice' named entity 'T cells' named entity 'vaccine'

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