About: SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques

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About: SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques
Creator	Sette, Alessandro Simmons, Graham Busch, Michael Miller, Christopher Tran, Nam Kozlowski, Pamela Morrison, John Rompay, Koen Carroll, Timothy Deere, Jesse Dutra, Joseph Elizaldi, Sonny Hartigan-O'connor, Dennis Immareddy, Ramya Iyer, Smita Ma, Zhong-Min Mcsorley, Stephen Nguyen, Nancy Olstad, Katherine Reader, J Roh, Jamin Sammak, Rebecca Schmidt, Brian Smith, Justin Usachaenko, Jodie Watanabe, Jennifer Weaver, Kourtney Weiskopf, Daniela Yee, Joann Lakshmanappa, Shaan
Source	BioRxiv; Medline; PMC
abstract	CD4 T follicular helper (T(fh)) cells are important for the generation of long-lasting and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T(fh) cells and stimulates the germinal center response is an important question as we investigate vaccine options for the current pandemic. Here we report that, following infection with SARS-CoV-2, adult rhesus macaques exhibited transient accumulation of activated, proliferating T(fh) cells in their peripheral blood on a transitory basis. The CD4 helper cell responses were skewed predominantly toward a T(h)1 response in blood, lung, and lymph nodes, reflective of the interferon-rich cytokine environment following infection. We also observed the generation of germinal center T(fh) cells specific for the SARS-CoV-2 spike (S) and nucleocapsid (N) proteins, and a corresponding early appearance of antiviral serum IgG antibodies but delayed or absent IgA antibodies. Our data suggest that a vaccine promoting T(h)1-type T(fh) responses that target the S protein may lead to protective immunity.
has issue date	2020-07-08(xsd:dateTime)
bibo:doi	10.1101/2020.07.07.191007
bibo:pmid	32676606
has license	cc-by-nc-nd
sha1sum (hex)	1a205ec964052eca0fcc32cbf2d47d039b7412f2
schema:url	https://doi.org/10.1101/2020.07.07.191007
resource representing a document's title	SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques
has PubMed Central identifier	PMC7359530
has PubMed identifier	32676606
schema:publication	bioRxiv
resource representing a document's body	covid:1a205ec964052eca0fcc32cbf2d47d039b7412f2#body_text
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