About: Antiviral Activity Against Infectious Bronchitis Virus and Bioactive Components of Hypericum perforatum L.

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About: Antiviral Activity Against Infectious Bronchitis Virus and Bioactive Components of Hypericum perforatum L. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Activity Against Infectious Bronchitis Virus and Bioactive Components of Hypericum perforatum L.
Creator	Li, Xunliang Ren, Yudong Zhang, Yue Li, Guangxing Abbas, Ghulam Chen, Huijie Diao, Lei Huang, Xiaodan Liu, Haixin Muhammad, Ishfaq Sun, Xiaoqi Zhang, Ruili Gallardo, Rodrigo Lall, Namrita Zhang, Muhammad
Source	Medline; PMC
abstract	Hypericum perforatum L., also known as Saint John’s Wort, has been well studied for its chemical composition and pharmacological activity. In this study, the antiviral activities of H. perforatum on infectious bronchitis virus (IBV) were evaluated in vitro and in vivo for the first time. The results of in vitro experiments confirmed that the antiviral component of H. perforatum was ethyl acetate extraction section (HPE), and results showed that treatment with HPE significantly reduced the relative messenger ribonucleic acid (mRNA) expression and virus titer of IBV, and reduced positive green immunofluorescence signal of IBV in chicken embryo kidney (CEK) cells. HPE treatment at doses of 480–120 mg/kg for 5 days, reduced IBV induced injury in the trachea and kidney, moreover, reduced the mRNA expression level of IBV in the trachea and kidney in vivo. The mRNA expression levels of IL-6, tumor necrosis factor alpha (TNF-α), and nuclear factor kappa beta (NF-κB) significantly decreased, but melanoma differentiation-associated protein 5 (MDA5), mitochondrial antiviral signaling gene, interferon alpha (IFN-α), and interferon beta (IFN-β) mRNA levels significantly increased in vitro and in vivo. Our findings demonstrated that HPE had significant anti-IBV effects in vitro and in vivo, respectively. In addition, it is possible owing to up-regulate mRNA expression of type I interferon through the MDA5 signaling pathway and down-regulate mRNA expression of IL-6 and TNF-α via the NF-κB signaling pathway. Moreover, the mainly active compositions of HPE analyzed by high-performance liquid chromatography/electrospray ionization–mass spectroscopy (ESI-MS) are hyperoside, quercitrin, quercetin, pseudohypericin, and hypericin, and a combination of these compounds could mediate the antiviral activities. This might accelerate our understanding of the antiviral effect of H. perforatum and provide new insights into the development of effective therapeutic strategies.
has issue date	2019-10-29(xsd:dateTime)
bibo:doi	10.3389/fphar.2019.01272
bibo:pmid	31736754
has license	cc-by
sha1sum (hex)	1a07962f8472f03e5159e01b742cf39295db17f5
schema:url	https://doi.org/10.3389/fphar.2019.01272
resource representing a document's title	Antiviral Activity Against Infectious Bronchitis Virus and Bioactive Components of Hypericum perforatum L.
has PubMed Central identifier	PMC6830131
has PubMed identifier	31736754
schema:publication	Front Pharmacol
resource representing a document's body	covid:1a07962f8472f03e5159e01b742cf39295db17f5#body_text
is schema:about of	named entity 'SIGNAL' named entity 'QUERCETIN' named entity 'EFFECT' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'LIQUID CHROMATOGRAPHY' named entity 'TREATMENT' named entity 'DEVELOPMENT' named entity 'RELATIVE' named entity 'COMPONENT' named entity 'SIGNIFICANT' named entity 'OUR' named entity 'DAYS' named entity '480' named entity 'EVALUATED' named entity 'ACCELERATE' named entity 'INTERFERON ' named entity 'DEMONSTRATED' named entity 'STRATEGIES' named entity 'EMBRYO' named entity 'UNDERSTANDING' named entity 'KIDNEY' named entity 'TUMOR NECROSIS FACTOR ALPHA ' named entity 'EXTRACTION' named entity 'NUCLEAR FACTOR KAPPA BETA' named entity 'MDA5 SIGNALING PATHWAY' named entity 'HYPERICIN' named entity 'CELLS' named entity 'HPE' named entity 'IL-6' named entity 'HYPERICUM PERFORATUM L.' named entity 'VIRUS' named entity 'INDUCED' named entity 'MITOCHONDRIAL' named entity 'MRNA' named entity 'SIGNALING GENE' named entity 'DECREASED' named entity 'PROVIDE' named entity 'PHARMACOLOGY' named entity 'addition' named entity 'chicken' named entity 'antiviral' named entity 'relative' named entity 'antiviral' named entity 'reduced' named entity 'cells' named entity 'quercitrin' named entity 'infectious bronchitis' named entity 'extraction' named entity 'HPE' named entity 'Wort' named entity 'provide' named entity 'spectroscopy' named entity 'Activity' named entity 'Frontiers' named entity 'JOURNAL ' covid:arg/1a07962f8472f03e5159e01b742cf39295db17f5 named entity 'SECTION' named entity 'EFFECTIVE' named entity 'INTERFERON ALPHA' named entity 'ACTIVE' named entity 'REGULATE' named entity 'SAINT JOHN' named entity 'KNOWN' named entity 'TYPE I INTERFERON' named entity 'CHICKEN' named entity 'QUERCITRIN' named entity 'LEVELS'

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