About: Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore

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About: Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore
Creator	Galvin, Jeffrey Chui, Paul Fukuoka, Junya Taubenberger, Jeffery Chong, Pek Franks, Teri Hayden, Dennis Lourens, Raina Ma, Elena Mcevoy, Peter Reid, Ann Selbs, Travis, William Usa, M
Source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome (SARS) is an infectious condition caused by the SARS-associated coronavirus (SARS-CoV), a new member in the family Coronaviridae. To evaluate the lung pathology in this life-threatening respiratory illness, we studied postmortem lung sections from 8 patients who died from SARS during the spring 2003 Singapore outbreak. The predominant pattern of lung injury in all 8 cases was diffuse alveolar damage. The histology varied according to the duration of illness. Cases of 10 or fewer days’ duration demonstrated acute-phase diffuse alveolar damage (DAD), airspace edema, and bronchiolar fibrin. Cases of more than 10 days’ duration exhibited organizing-phase DAD, type II pneumocyte hyperplasia, squamous metaplasia, multinucleated giant cells, and acute bronchopneumonia. In acute-phase DAD, pancytokeratin staining was positive in hyaline membranes along alveolar walls and highlighted the absence of pneumocytes. Multinucleated cells were shown to be both type II pneumocytes and macrophages by pancytokeratin, thyroid transcription factor-1, and CD68 staining. SARS-CoV RNA was identified by reverse transcriptase-polymerase chain reaction in 7 of 8 cases in fresh autopsy tissue and in 8 of 8 cases in formalin-fixed, paraffin-embedded lung tissue, including the 1 negative case in fresh tissue. Understanding the pathology of DAD in SARS patients may provide the basis for therapeutic strategies. Further studies of the pathogenesis of SARS may reveal new insight into the mechanisms of DAD.
has issue date	2003-08-31(xsd:dateTime)
bibo:doi	10.1016/s0046-8177(03)00367-8
bibo:pmid	14506633
has license	els-covid
sha1sum (hex)	19fdea95b1d73b7bdfcac831d3e742bacf9b31de
schema:url	https://doi.org/10.1016/s0046-8177%2803%2900367-8
resource representing a document's title	Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore
has PubMed Central identifier	PMC7119137
has PubMed identifier	14506633
schema:publication	Human Pathology
resource representing a document's body	covid:19fdea95b1d73b7bdfcac831d3e742bacf9b31de#body_text
is schema:about of	named entity 'Coronaviridae' named entity 'staining' named entity 'respiratory illness' named entity 'provide' named entity 'case' named entity 'patients' named entity 'edema' named entity 'AUTOPSY' covid:arg/19fdea95b1d73b7bdfcac831d3e742bacf9b31de named entity 'BASIS' named entity 'TISSUE' named entity 'POSTMORTEM' named entity 'CASES' named entity 'DURATION' named entity 'THYROID TRANSCRIPTION FACTOR' named entity 'MORE THAN' named entity 'PATIENTS' named entity 'LUNG TISSUE' named entity 'ABSENCE OF' named entity 'DAYS' named entity 'MACROPHAGES' named entity 'TYPE II' named entity 'NEW' named entity 'SARS-COV' named entity 'BRONCHIOLAR' named entity 'MULTINUCLEATED' named entity 'POSITIVE' named entity 'REVEAL' named entity 'CD68' named entity 'PATTERN' named entity 'DIED' named entity 'STAINING' named entity 'DEMONSTRATED' named entity 'FIBRIN' named entity 'MULTINUCLEATED GIANT CELLS' named entity 'LUNG' named entity 'FIXED' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'PATHOLOGY' named entity 'INSIGHT' named entity 'CELLS' named entity 'ALVEOLAR' named entity 'LUNG' named entity 'STUDY' named entity 'HYALINE MEMBRANES' named entity 'REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION' named entity 'NEGATIVE' named entity 'SINGAPORE' named entity 'LUNG INJURY' named entity 'CASES' named entity 'INCLUDING' named entity 'CASE' named entity 'PHASE' named entity 'AUTOPSY' named entity 'STUDIES' named entity 'SINGAPORE' named entity 'AIRSPACE' named entity 'STRATEGIES' named entity 'TYPE II PNEUMOCYTE HYPERPLASIA' named entity 'PANCYTOKERATIN' named entity 'PARAFFIN-EMBEDDED' named entity '748' named entity 'EDEMA' named entity 'WALLS' named entity 'SPRING' named entity 'PNEUMOCYTES' named entity 'EVALUATE' named entity 'OUTBREAK'

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