About: Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome
Creator	Tsangaris, Iraklis Kotanidou, Anastasia Giamarellos-Bourboulis, Evangelos Lada, Malvina Apostolidou, Efterpi Armaganidis, Apostolos Bristianou, Magdalini Gatselis, Nikolaos Georgitsi, Marianna Kanni, Theodora Kyprianou, Miltiades Perdios, Ioannis Sereti, Kalliopi
Source	PMC
abstract	INTRODUCTION: The aim of this study was to investigate the kinetics of immunoglobulin M (IgM) during the different stages of sepsis. METHODS: In this prospective multicenter study, blood sampling for IgM measurement was done within the first 24 hours from diagnosis in 332 critically ill patients; in 83 patients this was repeated upon progression to more severe stages. Among these 83 patients, 30 patients with severe sepsis progressed into shock and IgM was monitored daily for seven consecutive days. Peripheral blood mononuclear cells (PBMCs) were isolated from 55 patients and stimulated for IgM production. RESULTS: Serum IgM was decreased in septic shock compared to patients with systemic inflammatory response syndrome (SIRS) and patients with severe sepsis. Paired comparisons at distinct time points of the sepsis course showed that IgM was decreased only when patients deteriorated from severe sepsis to septic shock. Serial measurements in these patients, beginning from the early start of vasopressors, showed that the distribution of IgM over time was significantly greater for survivors than for non-survivors. Production of IgM by PBMCs was significantly lower at all stages of sepsis compared with healthy controls. CONCLUSIONS: Specific changes of circulating IgM occur when patients with severe sepsis progress into septic shock. The distribution of IgM is lower among non-survivors.
has issue date	2013-10-21(xsd:dateTime)
bibo:doi	10.1186/cc13073
bibo:pmid	24144038
has license	cc-by
sha1sum (hex)	19fc55dbef34b03dd94cad3565cf48628bfbe842
schema:url	https://doi.org/10.1186/cc13073
resource representing a document's title	Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome
has PubMed Central identifier	PMC4056013
has PubMed identifier	24144038
schema:publication	Crit Care
resource representing a document's body	covid:19fc55dbef34b03dd94cad3565cf48628bfbe842#body_text
is schema:about of	named entity 'patients' named entity 'septic shock' named entity 'investigate' named entity 'shock' named entity 'patients' named entity 'sepsis' named entity 'patients' named entity 'Kinetics' named entity 'circulating' named entity 'TIME' named entity 'ISOLATED' named entity 'CIRCULATING' named entity 'THESE' named entity 'sepsis' named entity 'IgM' named entity 'sepsis' named entity 'blood' named entity 'progression' named entity 'distribution' named entity 'septic shock' named entity 'mononuclear cells' named entity 'IgM' named entity 'IgM' named entity 'PBMCs' named entity 'daily' named entity 'IgM' named entity 'sepsis' named entity 'blood sampling' named entity 'patients' named entity 'measurements' named entity 'immunoglobulin M' named entity 'sepsis' named entity 'IgM' named entity 'severe sepsis' named entity 'early start' named entity 'Serum' named entity 'IgM' named entity 'IgM' named entity 'IgM' named entity 'sepsis' named entity 'severe sepsis' named entity 'critically ill patients' named entity 'IgM' named entity 'PBMCs' named entity 'septic shock' named entity 'systemic inflammatory response syndrome' named entity 'immunoglobulin' named entity 'kinetics' named entity 'PBMCs' named entity 'intra-abdominal infection' named entity 'Gram-negative bacteria' named entity 'IgM' named entity 'forward scatter' named entity 'IgM' named entity 'serum levels' named entity 'opsonization' named entity 'septic shock' named entity 'CRF' named entity 'agonist' named entity 'septic shock' named entity 'IgM' named entity 'IgM' named entity 'sepsis' named entity 'IgM' named entity 'WBC' named entity 'vasopressors' named entity 'systemic inflammatory response syndrome' named entity 'Germany' named entity 'Becton Dickinson'

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