About: Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

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About: Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters
Creator	Volmer, Romain Marianneau, Philippe Le Goffic, Ronan Picard-Meyer, Evelyne Servat, Alexandre Wasniewski, Marine Lesellier, Sandrine Monchatre-Leroy, Elodie Gouilh, Meriadeg Lacôte, Sandra Albin, Audrey Albin, St Bryche, Bertrand Goffic, Le Gouilh, Ar Lacôte, S Lesellier, M Meunier, Nicolas Meunier, P Murri, Severine Murri, A Pulido, Coralie Pulido, S Rampin, Olivier Rampin, R St Albin, Audrey Wasniewski, A
Source	Elsevier; Medline; PMC
abstract	Anosmia is one of the most prevalent symptoms of SARS-CoV-2 infection during the COVID-19 pandemic. However, the cellular mechanism behind the sudden loss of smell has not yet been investigated. The initial step of odour detection takes place in the pseudostratified olfactory epithelium (OE) mainly composed of olfactory sensory neurons surrounded by supporting cells known as sustentacular cells. The olfactory neurons project their axons to the olfactory bulb in the central nervous system offering a potential pathway for pathogens to enter the central nervous system by bypassing the blood brain barrier. In the present study, we explored the impact of SARS-COV-2 infection on the olfactory system in golden Syrian hamsters. We observed massive damage of the OE as early as 2 days post nasal instillation of SARS-CoV-2, resulting in a major loss of cilia necessary for odour detection. These damages were associated with infection of a large proportion of sustentacular cells but not of olfactory neurons, and we did not detect any presence of the virus in the olfactory bulbs. We observed massive infiltration of immune cells in the OE and lamina propria of infected animals, which may contribute to the desquamation of the OE. The OE was partially restored 14 days post infection. Anosmia observed in COVID-19 patient is therefore likely to be linked to a massive and fast desquamation of the OE following sustentacular cells infection with SARS-CoV-2 and subsequent recruitment of immune cells in the OE and lamina propria.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.1016/j.bbi.2020.06.032
bibo:pmid	32629042
has license	no-cc
sha1sum (hex)	19d28863ec38c5dcedbc516a6280dd50018e069b
schema:url	https://doi.org/10.1016/j.bbi.2020.06.032
resource representing a document's title	Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters
has PubMed Central identifier	PMC7332942
has PubMed identifier	32629042
schema:publication	Brain Behav Immun
resource representing a document's body	covid:19d28863ec38c5dcedbc516a6280dd50018e069b#body_text
is schema:about of	named entity 'Massive' named entity 'SARS-CoV-2' named entity 'IMMUNITY' named entity 'doi' named entity 'Immunity' named entity 'Behavior' named entity 'sustentacular' named entity 'infection' named entity 'sustentacular cells' named entity 'olfactory epithelium' named entity 'sustentacular cells' named entity 'olfactory mucosa' named entity 'central nervous' named entity 'hypothalamus' named entity 'olfactory bulb' named entity 'central nervous' named entity 'ACE2' named entity 'central nervous' named entity 'SARS-CoV2' named entity 'axon' named entity 'Sia' named entity 'olfactory nerves' named entity 'respiratory organs' named entity 'SARS-CoV2' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'OSN' named entity 'sustentacular cells' named entity 'staining' named entity 'cortex' named entity 'olfactory pathway' named entity 'olfactory mucosa' named entity 'ACE2' named entity 'RNA extraction' named entity 'lamina propria' named entity 'staining' named entity 'inflammation' named entity 'nasal cavity' named entity 'infection' named entity 'antibody' named entity 'receptor' named entity 'Anosmia' named entity 'RNA extraction' named entity 'staining' named entity 'quantitative PCR' named entity 'direct contact' named entity 'nasal cavity' named entity 'mice' named entity 'post-mortem' named entity 'COVID' named entity 'Supp' named entity 'lamina propria' named entity 'nasal cavity' named entity 'SARS-CoV-2' named entity 'hyposmia'

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