About: Development and validation a nomogram for predicting the risk of severe COVID-19: A multi-center study in Sichuan, China

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About: Development and validation a nomogram for predicting the risk of severe COVID-19: A multi-center study in Sichuan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development and validation a nomogram for predicting the risk of severe COVID-19: A multi-center study in Sichuan, China
Creator	Zhou, Yiwu Chen, Zhu Wang, Ting Liang, Zongan He, Yang, Huan Yu, He Yao Id, Rong
Source	Medline; PMC
abstract	BACKGROUND: Since December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and spread across the globe. The objective of this study is to build and validate a practical nomogram for estimating the risk of severe COVID-19. METHODS: A cohort of 366 patients with laboratory-confirmed COVID-19 was used to develop a prediction model using data collected from 47 locations in Sichuan province from January 2020 to February 2020. The primary outcome was the development of severe COVID-19 during hospitalization. The least absolute shrinkage and selection operator (LASSO) regression model was used to reduce data size and select relevant features. Multivariable logistic regression analysis was applied to build a prediction model incorporating the selected features. The performance of the nomogram regarding the C-index, calibration, discrimination, and clinical usefulness was assessed. Internal validation was assessed by bootstrapping. RESULTS: The median age of the cohort was 43 years. Severe patients were older than mild patients by a median of 6 years. Fever, cough, and dyspnea were more common in severe patients. The individualized prediction nomogram included seven predictors: body temperature at admission, cough, dyspnea, hypertension, cardiovascular disease, chronic liver disease, and chronic kidney disease. The model had good discrimination with an area under the curve of 0.862, C-index of 0.863 (95% confidence interval, 0.801–0.925), and good calibration. A high C-index value of 0.839 was reached in the interval validation. Decision curve analysis showed that the prediction nomogram was clinically useful. CONCLUSION: We established an early warning model incorporating clinical characteristics that could be quickly obtained on admission. This model can be used to help predict severe COVID-19 and identify patients at risk of developing severe disease.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0233328
bibo:pmid	32421703
has license	cc-by
sha1sum (hex)	19a2b476bded9c2fbb3c16c000510fc9de8c8d53
schema:url	https://doi.org/10.1371/journal.pone.0233328
resource representing a document's title	Development and validation a nomogram for predicting the risk of severe COVID-19: A multi-center study in Sichuan, China
has PubMed Central identifier	PMC7233581
has PubMed identifier	32421703
schema:publication	PLoS One
resource representing a document's body	covid:19a2b476bded9c2fbb3c16c000510fc9de8c8d53#body_text
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