About: Genetic associations of fatigue and other symptom domains of the acute sickness response to infection

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About: Genetic associations of fatigue and other symptom domains of the acute sickness response to infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genetic associations of fatigue and other symptom domains of the acute sickness response to infection
Creator	Lloyd, A Piraino, B Vollmer-Conna, U
source	Elsevier; Medline; PMC
abstract	Abstract The acute sickness response to infection is a conserved set of changes in physiology and behaviour, featuring fever, fatigue, musculo-skeletal pain, disturbed mood, and cognitive difficulties. The manifestations differ somewhat between individuals, including those infected with pathogens which do not have genetic variability – suggesting host determinants. Principal components analysis (PCA) was applied to acute phase, self-report symptom data from subjects in the Dubbo Infection Outcomes Study (n =296) to empirically derive indices of fatigue, pain, neurocognitive difficulties, and mood disturbance, as well as overall illness severity. Associations were sought with functional single nucleotide polymorphisms (SNPs) in the cytokine genes, interleukin (IL)-6, tumour necrosis factor (TNF)-α, interferon (IFN)-γ, and IL-10. The summed individual symptom indices correlated with overall severity and also with functional status. The relative contribution of individual symptom domains to the overall illness was stable over time within subjects, but varied between subjects with the same infection. The T allele of the IFN-γ +874 T/A SNP was associated with increased fatigue (p =0.0003; OR: 3.3). The C allele of the IL-10 −592 C/A SNP exerted a protective effect on neurocognitive difficulties (p =0.017; OR: 0.52); while the A allele for the IL-10 −592 SNP was associated with increased mood disturbance (p =0.044; OR: 1.83), as was the G allele of the IL-6 −174 G/C SNP (p =0.051; OR: 1.83). The acute sickness response has discrete symptom domains including fatigue, which have unique genetic associations. These data provide novel insights into the pathophysiology of fatigue states.
has issue date	2012-05-31(xsd:dateTime)
bibo:doi	10.1016/j.bbi.2011.12.009
bibo:pmid	22227623
has license	els-covid
sha1sum (hex)	19953b0a844a606812f7ea58aaa9b5ec2643536d
schema:url	https://doi.org/10.1016/j.bbi.2011.12.009
resource representing a document's title	Genetic associations of fatigue and other symptom domains of the acute sickness response to infection
has PubMed Central identifier	PMC7127134
has PubMed identifier	22227623
schema:publication	Brain, Behavior, and Immunity
resource representing a document's body	covid:19953b0a844a606812f7ea58aaa9b5ec2643536d#body_text
is schema:about of	named entity 'GENETIC' named entity 'associations' named entity 'fatigue' named entity 'domains' named entity 'FATIGUE' named entity 'INFECTION' named entity 'SYMPTOM' named entity 'PHYSIOLOGY' named entity 'CHANGES' named entity 'FATIGUE' named entity 'DETERMINANTS' named entity 'PATHOGENS' named entity 'DIFFICULTIES' named entity 'ACUTE' named entity 'ASSOCIATIONS' named entity 'SET' named entity 'DO NOT' named entity 'RESPONSE TO' named entity 'BEHAVIOUR' named entity 'INDIVIDUALS' named entity 'RESPONSE TO' named entity 'MANIFESTATIONS' named entity 'MOOD' named entity 'SICKNESS' named entity 'ACUTE' named entity 'IS A' named entity 'GENETIC VARIABILITY' named entity 'SKELETAL PAIN' named entity 'INFECTION' named entity 'INFECTED' named entity 'CONSERVED' named entity 'SOMEWHAT' named entity 'HOST' named entity 'INCLUDING' named entity 'HAVE' named entity 'FEVER' named entity 'COGNITIVE' named entity 'SICKNESS' covid:arg/19953b0a844a606812f7ea58aaa9b5ec2643536d named entity 'acute' named entity 'genetic variability' named entity 'individuals' named entity 'featuring' named entity 'physiology' named entity 'pathogens' named entity 'genetic variability' named entity 'fatigue' named entity 'infection' named entity 'allele' named entity 'Correlation' named entity 'IFN' named entity 'cytokine' named entity 'peripheral blood mononuclear cells' named entity 'SNP' named entity 'immunogenic' named entity 'pathogen' named entity 'correlation' named entity 'homozygous' named entity 'Spearman's correlations' named entity '95% CI' named entity 'interferon' named entity '95% CI' named entity 'endophenotype' named entity 'symptom' named entity 'acute infection' named entity 'symptom' named entity 'viral pathogens' named entity 'infection' named entity 'pathogen' named entity 'mouse model' named entity 'symptom' named entity 'Psychological Health' named entity 'oestrogens' named entity 'clinical practice' named entity 'Physical Symptoms' named entity 'symptom' named entity 'host response' named entity 'asymptomatic' named entity '2.11'

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