About: Proteomics computational analyses suggest that the carboxyl terminal glycoproteins of Bunyaviruses are class II viral fusion protein (beta-penetrenes)

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About: Proteomics computational analyses suggest that the carboxyl terminal glycoproteins of Bunyaviruses are class II viral fusion protein (beta-penetrenes) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proteomics computational analyses suggest that the carboxyl terminal glycoproteins of Bunyaviruses are class II viral fusion protein (beta-penetrenes)
Creator	Garry, Robert Garry, Courtney
Source	Medline; PMC
abstract	The Bunyaviridae family of enveloped RNA viruses includes five genuses, orthobunyaviruses, hantaviruses, phleboviruses, nairoviruses and tospoviruses. It has not been determined which Bunyavirus protein mediates virion:cell membrane fusion. Class II viral fusion proteins (beta-penetrenes), encoded by members of the Alphaviridae and Flaviviridae, are comprised of three antiparallel beta sheet domains with an internal fusion peptide located at the end of domain II. Proteomics computational analyses indicate that the carboxyl terminal glycoprotein (Gc) encoded by Sandfly fever virus (SAN), a phlebovirus, has a significant amino acid sequence similarity with envelope protein 1 (E1), the class II fusion protein of Sindbis virus (SIN), an Alphavirus. Similar sequences and common structural/functional motifs, including domains with a high propensity to interface with bilayer membranes, are located collinearly in SAN Gc and SIN E1. Gc encoded by members of each Bunyavirus genus share several sequence and structural motifs. These results suggest that Gc of Bunyaviridae, and similar proteins of Tenuiviruses and a group of Caenorhabditis elegans retroviruses, are class II viral fusion proteins. Comparisons of divergent viral fusion proteins can reveal features essential for virion:cell fusion, and suggest drug and vaccine strategies.
has issue date	2004-11-15(xsd:dateTime)
bibo:doi	10.1186/1742-4682-1-10
bibo:pmid	15544707
has license	cc-by
sha1sum (hex)	19744eafb1b8520fa460274845713451ad539e91
schema:url	https://doi.org/10.1186/1742-4682-1-10
resource representing a document's title	Proteomics computational analyses suggest that the carboxyl terminal glycoproteins of Bunyaviruses are class II viral fusion protein (beta-penetrenes)
has PubMed Central identifier	PMC535339
has PubMed identifier	15544707
schema:publication	Theor Biol Med Model
resource representing a document's body	covid:19744eafb1b8520fa460274845713451ad539e91#body_text
is schema:about of	named entity 'FUSION PROTEIN' named entity 'PROTEIN ' covid:arg/19744eafb1b8520fa460274845713451ad539e91 named entity 'GLYCOPROTEIN' named entity 'ALPHAVIRIDAE' named entity 'STRUCTURAL MOTIFS' named entity 'BUNYAVIRIDAE' named entity 'MEMBERS' named entity 'MOTIFS' named entity 'INTERNAL' named entity 'SEQUENCE' named entity 'PROTEOMICS' named entity 'RESULTS' named entity 'AT THE END' named entity 'BILAYER' named entity 'HIGH' named entity 'HANTAVIRUSES' named entity 'ENVELOPE PROTEIN' named entity 'CARBOXYL' named entity 'MEMBRANE FUSION' named entity 'VIRION' named entity 'FLAVIVIRIDAE' named entity 'OF EACH' named entity 'SIMILAR' named entity 'SAN' named entity 'AMINO ACID SEQUENCE' named entity 'SIN' named entity 'PROTEIN ' named entity 'SINDBIS VIRUS' named entity 'INCLUDING' named entity 'ENCODED' named entity 'VIRAL FUSION PROTEINS' named entity 'SUGGEST' named entity 'CLASS II' named entity 'PHLEBOVIRUSES' named entity 'RNA VIRUSES' named entity 'GENUS' named entity 'NAIROVIRUSES' named entity 'MODELLING' named entity 'ESSENTIAL' named entity 'SUGGEST' named entity 'SEQUENCE SIMILARITY' named entity 'BUNYAVIRUSES' named entity 'DETERMINED' named entity 'SIGNIFICANT' named entity 'GLYCOPROTEINS' named entity 'CARBOXYL' named entity 'PROTEOMICS' named entity 'VIRAL' named entity 'TERMINAL' named entity 'INCLUDES' named entity 'REVEAL' named entity 'SANDFLY FEVER VIRUS' named entity 'SHARE' named entity 'COMMON' named entity 'A GROUP' named entity 'FUSION PEPTIDE' named entity 'PROTEINS' named entity 'PHLEBOVIRUS' named entity 'MEDIATES' named entity 'TERMINAL' named entity 'VACCINE' named entity 'FUSION' named entity 'BUNYAVIRUS' named entity 'MEDICAL' named entity 'THEORETICAL BIOLOGY' named entity 'COMPUTATIONAL' named entity 'INTERFACE' named entity 'ALPHAVIRUS' named entity 'RETROVIRUSES' named entity 'FUSION PROTEIN' named entity 'DOMAIN' named entity 'CAENORHABDITIS ELEGANS' named entity 'CLASS II' named entity 'FAMILY' named entity 'FEATURES' named entity 'SEQUENCES' named entity 'COMPUTATIONAL' named entity 'THESE' named entity 'STRATEGIES'

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