About: Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylation-associated Recruitment of Transcription Factors to the Promoter

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About: Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylation-associated Recruitment of Transcription Factors to the Promoter Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylation-associated Recruitment of Transcription Factors to the Promoter
Creator	Zhu, Ying Li, Wei Wu, Jianguo Sun, Wei Xu, Dongping Mu, Yongxin Yang, Fang Yang, Yongbo Yue, Xin
source	Medline; PMC
abstract	BACKGROUND: The hepatitis B virus (HBV) is a major etiological factor of inflammation and damage to the liver resulting in hepatocellular carcinoma. Transcription factors play important roles in the disordered gene expression and liver injury caused by HBV. However, the molecular mechanisms behind this observation have not been defined. RESULTS: In this study, we observed that circulating prostaglandin (PGE) 2 synthesis was increased in patients with chronic hepatitis B infection, and detected elevated cyclooxygenase (COX)-2 expression in HBV- and HBx-expressing liver cells. Likewise, the association of HBx with C/EBPβ contributed to the induction of COX-2. The COX-2 promoter was hypomethylated in HBV-positive cells, and specific demethylation of CpG dinucleotides within each of the two NF-AT sites in the COX-2 promoter resulted in the increased binding affinity of NF-AT to the cognate sites in the promoter, followed by increased COX-2 expression and PGE2 accumulation. The DNA methylatransferase DNMT3B played a key role in the methylation of the COX-2 promoter, and its decreased binding to the promoter was responsible for the regional demethylation of CpG sites, and for the increased binding of transcription factors in HBV-positive cells. CONCLUSION: Our results indicate that upregulation of COX-2 by HBV and HBx is mediated by both demethylation events and recruitment of multiple transcription factors binding to the promoter.
has issue date	2011-03-14(xsd:dateTime)
bibo:doi	10.1186/1743-422x-8-118
bibo:pmid	21401943
has license	cc-by
sha1sum (hex)	1968f8d8ffe3f695372d919c9966b1ca412b83d2
schema:url	https://doi.org/10.1186/1743-422x-8-118
resource representing a document's title	Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylation-associated Recruitment of Transcription Factors to the Promoter
has PubMed Central identifier	PMC3066118
has PubMed identifier	21401943
schema:publication	Virol J
resource representing a document's body	covid:1968f8d8ffe3f695372d919c9966b1ca412b83d2#body_text
is schema:about of	named entity 'responsible' named entity 'binding affinity' named entity 'DNMT3B' named entity 'Cyclooxygenase-2' named entity 'Transcription' named entity 'Promoter' named entity 'RECRUITMENT' named entity 'SITES' named entity 'RESULTS' named entity 'BACKGROUND' named entity 'SPECIFIC' named entity 'INDUCTION' named entity 'ROLES' named entity 'ACCUMULATION' named entity 'FOLLOWED BY' named entity 'DEFINED' named entity 'PGE2' named entity 'ELEVATED' named entity 'GENE EXPRESSION' named entity 'ASSOCIATION' named entity 'LIVER INJURY' named entity 'COX-2' named entity 'EXPRESSION' named entity 'DEMETHYLATION' named entity 'DAMAGE' named entity 'IS A' named entity 'PROMOTER' named entity 'ROLE' named entity 'RESPONSIBLE' named entity 'POSITIVE' named entity 'STUDY' named entity 'CIRCULATING' named entity 'DISORDERED' named entity 'PLAY' named entity 'CHRONIC HEPATITIS B INFECTION' named entity 'HBV' named entity 'LIVER CELLS' named entity 'INFLAMMATION' named entity 'PATIENTS' named entity 'SYNTHESIS' named entity 'HEPATITIS B VIRUS' named entity 'MOLECULAR' named entity 'TRANSCRIPTION FACTORS' named entity 'PROMOTER' named entity 'ASSOCIATED' named entity 'DEMETHYLATION' named entity 'INDUCTION' named entity 'FACTOR' named entity 'A MAJOR' named entity 'IMPORTANT' named entity 'BINDING AFFINITY' named entity 'DNA' named entity 'DNMT3B' named entity 'INCREASED' named entity 'CELLS' named entity 'REGIONAL' named entity 'RESULTING IN' named entity 'TRANSCRIPTION FACTORS' named entity 'DINUCLEOTIDES' named entity 'CPG' named entity 'HAVE' named entity 'CYCLOOXYGENASE' named entity 'METHYLATION' named entity 'DETECTED' named entity 'HEPATITIS B VIRUS' named entity 'CYCLOOXYGENASE-2' named entity 'EXPRESSION' named entity 'MECHANISMS' named entity 'OBSERVED' named entity 'ITS' named entity 'CAUSED BY' named entity 'HEPATOCELLULAR CARCINOMA' named entity 'KEY'

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