About: Saikosaponin-d Enhances the Anticancer Potency of TNF-α via Overcoming Its Undesirable Response of Activating NF-Kappa B Signalling in Cancer Cells

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About: Saikosaponin-d Enhances the Anticancer Potency of TNF-α via Overcoming Its Undesirable Response of Activating NF-Kappa B Signalling in Cancer Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Saikosaponin-d Enhances the Anticancer Potency of TNF-α via Overcoming Its Undesirable Response of Activating NF-Kappa B Signalling in Cancer Cells
Creator	Liu, Liang Zhou, Hua Kam, Vincent Wong, Wai Chan, Po Zhang, Molly Ka, Carmen Lam, Ching Law, Man Yin, Kelly Ying, Patrick Yue, Kit
Source	PMC
abstract	Tumor necrosis factor-alpha (TNF-α) was reported as anticancer therapy due to its cytotoxic effect against an array of tumor cells. However, its undesirable responses of TNF-α on activating NF-κB signaling and pro-metastatic property limit its clinical application in treating cancers. Therefore, sensitizing agents capable of overcoming this undesirable effect must be valuable for facilitating the usage of TNF-α-mediated apoptosis therapy for cancer patients. Previously, saikosaponin-d (Ssd), a triterpene saponin derived from the medicinal plant, Bupleurum falcatum L. (Umbelliferae), showed to exhibit a variety of pharmacological activities such as antiinflammation, antibacteria, antivirus and anticancer. Recently, we found that Ssd could inhibit the activated T lymphocytes via suppression of NF-κB, NF-AT and AP-1 signaling. Here, we showed that Ssd significantly potentiated TNF-α-mediated cell death in HeLa and HepG2 cancer cells via suppression of TNF-α-induced NF-κB activation and its target genes expression involving cancer cell proliferation, invasion, angiogenesis and survival. Also, Ssd revealed a significant potency of abolishing TNF-α-induced cancer cell invasion and angiogenesis in HUVECs while inducing apoptosis via enhancing the loss of mitochondrial membrane potential in HeLa cells. Collectively, these findings indicate that Ssd has a significant potential to be developed as a combined adjuvant remedy with TNF-α for cancer patients.
has issue date	2013-03-12(xsd:dateTime)
bibo:doi	10.1155/2013/745295
bibo:pmid	23573150
has license	cc-by
sha1sum (hex)	190bc9d8aadbfb5c848ccdb9f4fa98610780ba56
schema:url	https://doi.org/10.1155/2013/745295
resource representing a document's title	Saikosaponin-d Enhances the Anticancer Potency of TNF-α via Overcoming Its Undesirable Response of Activating NF-Kappa B Signalling in Cancer Cells
has PubMed Central identifier	PMC3610377
has PubMed identifier	23573150
schema:publication	Evid Based Complement Alternat Med
resource representing a document's body	covid:190bc9d8aadbfb5c848ccdb9f4fa98610780ba56#body_text
is schema:about of	named entity 'potential' named entity 'potential' named entity 'antivirus' named entity 'cancer' named entity 'Cells' named entity 'ITS' named entity 'ANTICANCER' named entity 'ITS' named entity 'SSD' named entity 'ACTIVITIES' named entity 'AP-1' named entity 'CANCER CELLS' named entity 'ACTIVATED' named entity 'TNF' named entity 'NF-AT' named entity 'USAGE' named entity 'COMBINED' named entity 'LOSS OF' named entity 'GENES' named entity 'CANCERS' named entity 'INVOLVING' named entity 'TUMOR NECROSIS FACTOR-ALPHA' named entity 'HELA CELLS' named entity 'APOPTOSIS' named entity 'ANTICANCER' named entity 'CANCER' named entity 'POTENCY' named entity 'CYTOTOXIC EFFECT' named entity 'MEDIATED' named entity 'INDUCING' named entity 'TRITERPENE' named entity 'T LYMPHOCYTES' named entity 'POTENTIAL' named entity 'THERAPY' named entity 'PATIENTS' named entity 'MITOCHONDRIAL MEMBRANE POTENTIAL' named entity 'PREVIOUSLY' named entity 'MEDICINAL PLANT' named entity 'SIGNALING' named entity 'RESPONSES' named entity 'FINDINGS' named entity 'VARIETY' named entity 'SURVIVAL' named entity 'CELL INVASION' named entity 'INVASION' named entity 'PRO-' named entity 'RESPONSE' named entity 'THESE' named entity 'PROPERTY' named entity 'DERIVED' named entity 'HEPG2' named entity 'INDUCED' named entity 'METASTATIC' named entity 'ADJUVANT' named entity 'SAPONIN' named entity 'PHARMACOLOGICAL' named entity 'REVEALED' named entity 'HELA' named entity 'ACTIVATING' named entity 'NF-KAPPA B' named entity 'TNF' named entity 'CANCER CELLS' named entity 'POTENCY' named entity 'REPORTED' named entity 'TUMOR CELLS' named entity 'ANGIOGENESIS' named entity 'BUPLEURUM FALCATUM' named entity 'ANTICANCER THERAPY' named entity 'TREATING' named entity 'TARGET'

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