About: Antiproliferative effect of Toona sinensis leaf extract on non

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About: Antiproliferative effect of Toona sinensis leaf extract on non–small-cell lung cancer Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiproliferative effect of Toona sinensis leaf extract on non–small-cell lung cancer
Creator	Hsu, Hseng-Kuang Huang, Ming-Shyan Wang, Pei-Hui Chen, Yu-Chu Huang, Yu-Jung Tsai, May-Jywan Wang, Cheng-Yuan Yang, Chih-Jen Kaohsiung, Ching-Feng Kumar, V
Source	Elsevier; Medline; PMC
abstract	Toona sinensis (TS), which is also known as Cedrela sinensis, belongs to Meliaceae family, the compounds identified from this TS leaves possess a wide range of biologic functions, such as hypoglycemic effects, anti–LDL glycative activity, antioxidant activities, and inhibition of sudden acute respiratory syndrome (SARS) coronavirus replication. However, their effect against cancer cells is not well explored. In this study, to understand the cytotoxic effect and molecular mechanism stimulated by TSL-1 (TS leaf extract fraction) we employed three different non–small-cell lung cancer (NSCLC) cell lines: H441 cells (lung adenocarcinoma), H661 cells (lung large cell carcinoma) and H520 cells (lung squamous cell carcinoma). IC50 value was varied between these three cell lines, the least IC50 value was observed in TSL-1–treated H661cells. Exposure of NSCLC cells to TSL-1 caused cell-cycle arrest in subG1 phase and caused apoptosis. Moreover, TSL-1 treatment decreased the cell-cycle regulators; cyclin D1 and CDK4 proteins by up regulating p27 expression in a dose-dependent manner. Thus, the TSL-1–induced apoptosis was further confirmed by cell morphology, subG1 peak accumulation, poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) cleavage, propidium iodide (PI)-Annexin-V double staining, and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay. The decreased Bcl2 protein level was concurrent with an increased Bax protein level in all 3 cell lines. Additionally, the tumoricidal effect of TSL-1 was measured using a xenograft model, after 5 weeks of TSL-1 treatment by various regimen caused regression of tumor. Taken together both these in vitro and in vivo studies revealed that TSL-1 is a potent inhibitor against NSCLC growth and our provoking result suggest that TSL-1 can be a better nutriceutical as a singlet or along with doublet agents (taxane, vinorelbine, and gemcitabine) for treating NSCLC.
has issue date	2010-06-30(xsd:dateTime)
bibo:doi	10.1016/j.trsl.2010.03.002
bibo:pmid	20478545
has license	els-covid
sha1sum (hex)	18e0f53c82db254bfa884517bef263d9e8fecc53
schema:url	https://doi.org/10.1016/j.trsl.2010.03.002
resource representing a document's title	Antiproliferative effect of Toona sinensis leaf extract on non–small-cell lung cancer
has PubMed Central identifier	PMC7185486
has PubMed identifier	20478545
schema:publication	Translational Research
resource representing a document's body	covid:18e0f53c82db254bfa884517bef263d9e8fecc53#body_text
is schema:about of	named entity 'studies' named entity 'revealed' named entity 'Meliaceae' named entity 'regression' named entity 'manner' named entity 'The' named entity 'taxane' named entity 'caused' named entity 'PARP' named entity 'gemcitabine' named entity 'room temperature' named entity 'cyclin D1' named entity 'p27' named entity 'leaf' named entity 'CORONAVIRUS REPLICATION' named entity 'VINORELBINE' named entity 'ACCUMULATION' named entity 'TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE' named entity 'CYCLIN-DEPENDENT KINASE' named entity 'CONFIRMED BY' named entity 'DUTP' named entity 'VARIOUS' named entity 'PROTEIN LEVEL' named entity 'SUGGEST' named entity 'PARP' named entity 'DYE' named entity 'SKOV3' named entity 'BUFFERED' named entity 'THEIR' named entity 'ANTIOXIDANT' named entity 'IC50' named entity 'CELL LINES' named entity 'MOLECULAR MECHANISM' named entity 'FACS' named entity 'TUNEL' named entity 'SINGLET' named entity 'DOUBLE' named entity 'FBS' named entity 'VALUE' named entity 'SYNDROME' named entity 'PHOSPHATE' named entity 'END' named entity 'GROWTH' named entity 'REGIMEN' named entity 'POLY' covid:arg/18e0f53c82db254bfa884517bef263d9e8fecc53 named entity 'APOPTOSIS' named entity 'NON-SMALL-CELL LUNG CANCER' named entity 'LEAF' named entity 'LEAVES' named entity '5 WEEKS' named entity 'CYTOTOXIC EFFECT' named entity 'LDL' named entity 'ARREST' named entity 'XENOGRAFT MODEL' named entity 'PBS' named entity 'GEMCITABINE' named entity 'CLEAVAGE' named entity 'OVARIAN CANCER CELL' named entity 'THESE' named entity 'RESEARCH' named entity 'POSSESS' named entity 'WIDE' named entity 'OUR' named entity 'ECL' named entity 'TOONA SINENSIS' named entity 'EFFECT' named entity 'ANTIPROLIFERATIVE' named entity 'ADENOCARCINOMA' named entity 'EXTRACT FRACTION' named entity 'TREATMENT' named entity 'POLYMERASE'

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