About: HIV entry in macrophages is dependent on intact lipid rafts

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	HIV entry in macrophages is dependent on intact lipid rafts
Creator	Bernstone, Laura Harder, Thomas James, William Sangani, Dhaval Bee, Jessica Carter, Gemma
Source	Elsevier; Medline; PMC
abstract	Abstract Macrophages are an important natural target cell for HIV-1, but previous studies of virus entry into these cells are limited, and the involvement of membrane cholesterol and lipid rafts is unknown. Cholesterol disruption of macrophage membranes using four pharmacological agents acting by different mechanisms: methyl-β cyclodextrin, nystatin, filipin complex and Lovastatin, all significantly inhibited productive HIV entry and reverse transcription. The inhibitory effects of these drugs resulted in decreased virus release from infected cells, and could be substantially reversed by the addition of water-soluble cholesterol. The virus bound equally to cholesterol-disrupted cells even though HIV receptor expression levels were significantly reduced. Macrophage CD4 and CCR5 were found to partition with the detergent-resistant membranes with a typical raft-associating protein flotillin-1. HIV particles were observed co-localising with a marker of lipid rafts (CTB-FITC) early post infection. These data suggest that macrophage membrane cholesterol is essential for HIV entry, and implicate lipid raft involvement.
has issue date	2009-03-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2008.12.031
bibo:pmid	19185899
has license	els-covid
sha1sum (hex)	18c439715360fd8a572c0995be75dae63823217a
schema:url	https://doi.org/10.1016/j.virol.2008.12.031
resource representing a document's title	HIV entry in macrophages is dependent on intact lipid rafts
has PubMed Central identifier	PMC7103383
has PubMed identifier	19185899
schema:publication	Virology
resource representing a document's body	covid:18c439715360fd8a572c0995be75dae63823217a#body_text
is schema:about of	named entity 'FOUND' named entity 'REVERSED' named entity 'CELLS' named entity 'MACROPHAGES' named entity 'DISRUPTION' named entity 'FITC' named entity 'LIMITED' named entity 'INHIBITED' named entity 'USING' named entity 'FILIPIN' named entity 'IMPORTANT' named entity 'INFECTION' named entity 'REDUCED' named entity 'DETERGENT' named entity 'VIRUS' named entity 'ADDITION' named entity 'PROTEIN ' named entity 'NYSTATIN' named entity 'PHARMACOLOGICAL' named entity 'FLOTILLIN-1' named entity 'POST' named entity 'DRUGS' named entity 'RAFT' named entity 'HIV' covid:arg/18c439715360fd8a572c0995be75dae63823217a named entity 'MACROPHAGES' named entity 'WATER-SOLUBLE' named entity 'INTACT' named entity 'TARGET CELL' named entity 'EARLY' named entity 'BOUND' named entity 'PARTITION' named entity 'TYPICAL' named entity 'PARTICLES' named entity 'DIFFERENT' named entity 'RESISTANT' named entity 'BUT' named entity 'ASSOCIATING' named entity 'ESSENTIAL' named entity 'MEMBRANE' named entity 'UNKNOWN' named entity 'COULD BE' named entity 'CD4' named entity 'STUDIES' named entity 'LIPID RAFTS' named entity 'RECEPTOR EXPRESSION' named entity 'VIRUS ENTRY' named entity 'PRODUCTIVE' named entity 'HIV' named entity 'ENTRY' named entity 'DATA' named entity 'ENTRY' named entity 'INHIBITORY' named entity 'CYCLODEXTRIN' named entity 'METHYL' named entity 'OBSERVED' named entity 'CCR5' named entity 'LIPID RAFTS' named entity 'HIV-1' named entity 'DECREASED' named entity 'VIRUS RELEASE' named entity 'CHOLESTEROL' named entity 'COMPLEX' named entity 'LEVELS' named entity 'MARKER' named entity 'MECHANISMS' named entity 'HIV RECEPTOR' named entity 'MEMBRANES' named entity 'THESE' named entity 'DEPENDENT' named entity 'EFFECTS' named entity 'DISRUPTED' named entity 'INVOLVEMENT' named entity 'PREVIOUS' named entity 'LIPID RAFT' named entity 'MACROPHAGE'

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