About: Evolutionary origins of epidemic potential among human RNA viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evolutionary origins of epidemic potential among human RNA viruses
Creator	Lu, Lu Woolhouse, Mark Simmonds, Peter Zhang, Feifei Chase-Topping, Margo Brierley, Liam Lycett, Samantha Robertson, Gail Smith, Donald
Source	BioRxiv; MedRxiv
abstract	To have epidemic potential, a pathogen must be able to spread in human populations, but of human-infective RNA viruses only a minority can do so. We investigated the evolution of human transmissibility through parallel analyses of 1755 virus genome sequences from 39 RNA virus genera. We identified 57 lineages containing human-transmissible species and estimated that at least 74% of these lineages have evolved directly from non-human viruses in other mammals or birds, a public health threat recently designated “Disease X”. Human-transmissible viruses rarely evolve from virus lineages that can infect but not transmit between humans. This result cautions against focussing surveillance and mitigation efforts narrowly on currently known human-infective virus lineages and supports calls for a better understanding of RNA virus diversity in non-human hosts.
has issue date	2019-09-18(xsd:dateTime)
bibo:doi	10.1101/771394
has license	biorxiv
sha1sum (hex)	18aae580d26ff3c0694e9f97d379e87cbc9bccda
schema:url	https://doi.org/10.1101/771394
resource representing a document's title	Evolutionary origins of epidemic potential among human RNA viruses
schema:publication	bioRxiv
resource representing a document's body	covid:18aae580d26ff3c0694e9f97d379e87cbc9bccda#body_text
is schema:about of	named entity 'infect' named entity 'mitigation' named entity 'evolve' named entity 'viruses' named entity 'Introduction' named entity 'evolved' named entity 'infectious disease' named entity 'viruses' named entity 'virus' named entity 'birds' named entity 'RNA' named entity 'estimated' named entity 'viruses' named entity 'virus genome' named entity 'virus' named entity 'RNA virus' named entity 'viruses' named entity 'virus' named entity 'public health' named entity 'maximum likelihood' named entity 'Heat map' named entity 'virus' named entity 'phylogenetic analyses' named entity 'lentiviruses' named entity 'epidemic' named entity 'protein sequences' named entity 'transmissibility' named entity 'phylogenetic signal' named entity 'mammal' named entity 'taxa' named entity 'virus' named entity 'RNA viruses' named entity 'virus' named entity 'virus species' named entity 'phylogenetic analysis' named entity 'Ebolavirus' named entity 'evolution' named entity 'phylogenies' named entity 'phylogenies' named entity 'NL63' named entity 'mammal' named entity 'virus' named entity 'genus' named entity 'genus' named entity 'hepatitis' named entity 'ssRNA' named entity 'response variable' named entity 'virus' named entity 'parsimony analysis' named entity 'genus' named entity 'maximum likelihood method' named entity 'host range' named entity 'genus' named entity 'Bayesian' named entity 'virus' named entity 'genus' named entity 'parsimony' named entity 'host range' named entity 'Influenza A virus' named entity 'evolution' named entity 'genus' named entity 'explanatory variable' named entity 'phylogenetic signal' named entity 'topology' named entity 'taxa' named entity 'genus' named entity 'normal distribution' named entity 'measles virus' named entity 'polymerase' named entity 'empirical support' named entity '1, 2' named entity 'reservoir host' named entity 'RNA virus' named entity 'RNA virus' named entity 'taxa' named entity 'convergent evolution'

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