About: CD8-deficient SJL mice display enhanced susceptibility to Theiler’s virus infection and increased demyelinating pathology

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: CD8-deficient SJL mice display enhanced susceptibility to Theiler’s virus infection and increased demyelinating pathology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	CD8-deficient SJL mice display enhanced susceptibility to Theiler’s virus infection and increased demyelinating pathology
Creator	Haynes, Lia Begolka, Wendy Dal Canto, Mauro Kim, Byung Miller, Stephen Neville, Katherine Olson, Julie Padilla, Josette Palma, Joann
source	Medline; PMC
abstract	Theiler’s murine encephalomyelitis virus (TMEV) infection of the central nervous system (CNS) induces a chronic, progressive demyelinating disease in susceptible mouse strains characterized by inflammatory mononuclear infiltrates and spastic hind limb paralysis. Our lab has previously demonstrated a critical role for TMEV- and myelin-specific CD4(+) T cells in initiating and perpetuating this pathology. It has however, also been shown that the MHC class I loci are associated with susceptibility/resistance to TMEV infection and persistence. For this reason, we investigated the contribution of CD8(+) T cells to the TMEV-induced demyelinating pathology in the highly susceptible SJL/J mouse strain. Here we show that β2M-deficient SJL mice have similar disease incidence rates to wild-type controls, however β2M-deficient mice demonstrated earlier onset of clinical disease, elevated in vitro responses to TMEV and myelin proteolipid (PLP) epitopes, and significantly higher levels of CNS demyelination and macrophage infiltration at 50 days post-infection. β2M-deficient mice also displayed a significant elevation in persisting viral titers, as well as an increase in macrophage-derived pro-inflammatory cytokine mRNA expression in the spinal cord at this same time point. Taken together, these results indicate that CD8(+) T cells are not required for clinical or histologic disease initiation or progression in TMEV-infected SJL mice. Rather, these data stress the critical role of CD4(+) T cells in this capacity and further emphasize the potential for CD8(+) T cells to contribute to protection from TMEV-induced demyelination.
has issue date	2001-01-01(xsd:dateTime)
bibo:doi	10.1080/135502801753170264
bibo:pmid	11582513
has license	no-cc
sha1sum (hex)	187f4c43d5cff143d5e2eb71f0f594775fe9a445
schema:url	https://doi.org/10.1080/135502801753170264
resource representing a document's title	CD8-deficient SJL mice display enhanced susceptibility to Theiler’s virus infection and increased demyelinating pathology
has PubMed Central identifier	PMC7094986
has PubMed identifier	11582513
schema:publication	J Neurovirol
resource representing a document's body	covid:187f4c43d5cff143d5e2eb71f0f594775fe9a445#body_text
is schema:about of	named entity 'CD8' named entity 'CD4' named entity 'levels' named entity 'disease' named entity 'demyelination' named entity 'CD8' named entity 'DISPLAY' named entity 'MICE' named entity 'INFECTED' named entity 'NOT REQUIRED' named entity 'CYTOKINE ' named entity 'POST' named entity 'TMEV' named entity 'RESPONSES' named entity 'SUSCEPTIBILITY' named entity 'INDUCED' named entity 'DEMONSTRATED' named entity 'TIME POINT' named entity 'THESE' named entity 'INCREASE' named entity 'PRO-' named entity 'PROTECTION' named entity 'RESULTS' named entity 'VIRAL' named entity 'PROGRESSION' named entity 'MACROPHAGE' named entity 'HISTOLOGIC' named entity 'SJL' named entity 'CD8' named entity 'MICE' named entity 'ONSET OF' named entity 'INCREASED' named entity 'ENHANCED' named entity '27S' named entity 'ELEVATED' named entity 'ROLE' named entity 'CNS DEMYELINATION' named entity 'DAYS' named entity 'SPINAL CORD' named entity 'VIRUS INFECTION' named entity 'DERIVED' named entity 'HAVE' named entity 'INITIATION' named entity 'MYELIN PROTEOLIPID' named entity 'CD4' named entity 'TAKEN' named entity 'SIMILAR' named entity 'EPITOPES' named entity 'RATHER' named entity 'CONTRIBUTE ' named entity 'STRESS' named entity 'WILD-TYPE' named entity 'POTENTIAL' named entity 'CAPACITY' named entity 'CD8' named entity 'PATHOLOGY' named entity 'EARLIER' named entity 'SJL' named entity 'T CELLS' named entity 'DATA' named entity 'ELEVATION' named entity 'CANT' named entity 'INCIDENCE' named entity 'DISPLAYED' named entity 'HIGHER' named entity 'INFECTION' named entity 'IN VITRO' named entity 'RATES' named entity 'CLINICAL' named entity 'HERE' named entity 'DEMYELINATION' named entity 'MRNA EXPRESSION' named entity 'CRITICAL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software