About: In Vitro Infection of Pupae with Israeli Acute Paralysis Virus Suggests Disturbance of Transcriptional Homeostasis in Honey Bees (Apis mellifera)

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: In Vitro Infection of Pupae with Israeli Acute Paralysis Virus Suggests Disturbance of Transcriptional Homeostasis in Honey Bees (Apis mellifera) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In Vitro Infection of Pupae with Israeli Acute Paralysis Virus Suggests Disturbance of Transcriptional Homeostasis in Honey Bees (Apis mellifera)
Creator	Murphy, Charles Jan, Eric Boncristiani, Humberto Chen, Yanping Evans, Jay Lopez, Dawn Pettis, Jeff Rueppell, Olav Simone-Finstrom, Michael Strand, Micheline Tarpy, David
Source	PMC
abstract	The ongoing decline of honey bee health worldwide is a serious economic and ecological concern. One major contributor to the decline are pathogens, including several honey bee viruses. However, information is limited on the biology of bee viruses and molecular interactions with their hosts. An experimental protocol to test these systems was developed, using injections of Israeli Acute Paralysis Virus (IAPV) into honey bee pupae reared ex-situ under laboratory conditions. The infected pupae developed pronounced but variable patterns of disease. Symptoms varied from complete cessation of development with no visual evidence of disease to rapid darkening of a part or the entire body. Considerable differences in IAPV titer dynamics were observed, suggesting significant variation in resistance to IAPV among and possibly within honey bee colonies. Thus, selective breeding for virus resistance should be possible. Gene expression analyses of three separate experiments suggest IAPV disruption of transcriptional homeostasis of several fundamental cellular functions, including an up-regulation of the ribosomal biogenesis pathway. These results provide first insights into the mechanisms of IAPV pathogenicity. They mirror a transcriptional survey of honey bees afflicted with Colony Collapse Disorder and thus support the hypothesis that viruses play a critical role in declining honey bee health.
has issue date	2013-09-05(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0073429
bibo:pmid	24039938
has license	cc0
sha1sum (hex)	1842bb195a368132b3f4b433e1b1a71590fdc31e
schema:url	https://doi.org/10.1371/journal.pone.0073429
resource representing a document's title	In Vitro Infection of Pupae with Israeli Acute Paralysis Virus Suggests Disturbance of Transcriptional Homeostasis in Honey Bees (Apis mellifera)
has PubMed Central identifier	PMC3764161
has PubMed identifier	24039938
schema:publication	PLoS One
resource representing a document's body	covid:1842bb195a368132b3f4b433e1b1a71590fdc31e#body_text
is schema:about of	named entity 'transcriptional' named entity 'worldwide' named entity 'experimental protocol' named entity 'Thus' named entity 'decline' named entity 'declining' named entity 'support' named entity 'complete' named entity 'viruses' named entity 'rapid' named entity 'Transcriptional' covid:arg/1842bb195a368132b3f4b433e1b1a71590fdc31e named entity 'IN VITRO' named entity 'HYPOTHESIS' named entity 'THESE' named entity 'MIRROR' named entity 'INJECTIONS' named entity 'COLONIES' named entity 'RESISTANCE TO' named entity 'COLONY COLLAPSE DISORDER' named entity 'DYNAMICS' named entity 'HOMEOSTASIS' named entity 'EVIDENCE OF' named entity 'OBSERVED' named entity 'CONCERN' named entity 'ISRAELI ACUTE PARALYSIS VIRUS' named entity 'LIMITED' named entity 'SEPARATE' named entity 'BUT' named entity 'HONEY BEE' named entity 'PLAY' named entity 'SURVEY' named entity 'ENTIRE' named entity 'VISUAL' named entity 'RAPID' named entity 'VARIATION' named entity 'DEVELOPMENT' named entity 'COMPLETE' named entity 'ECOLOGICAL' named entity 'CELLULAR' named entity 'VIRUSES' named entity 'DECLINING' named entity 'HOSTS' named entity 'CONTRIBUTOR' named entity 'BIOLOGY' named entity 'VARIABLE' named entity 'TO TEST' named entity 'SIGNIFICANT' named entity 'SELECTIVE BREEDING' named entity 'IS A' named entity 'SYMPTOMS' named entity 'DISRUPTION' named entity 'SUPPORT' named entity 'FUNCTIONS' named entity 'INCLUDING' named entity 'CONSIDERABLE' named entity 'ECONOMIC' named entity 'WORLDWIDE' named entity 'MECHANISMS' named entity 'INFECTED' named entity 'INFECTION' named entity 'PUPAE' named entity 'TRANSCRIPTIONAL' named entity 'HOMEOSTASIS' named entity 'HONEY BEES' named entity 'DISTURBANCE' named entity 'SUGGEST' named entity 'THEIR' named entity 'HONEY BEES' named entity 'RESULTS' named entity 'PATTERNS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software