About: Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

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About: Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
Creator	Takeda, Makoto Krammer, Florian Suzuki, Tadaki Kawaoka, Yoshihiro Kuroda, Makoto Ohmagari, Norio Nakajima, Noriko Watanabe, Tokiko Fan, Shufang Hatta, Masato Takahashi, Kenta Yamayoshi, Seiya Imai, Masaki Halfmann, Peter Ito, Mutsumi Iwatsuki-Horimoto, Kiyoko Kiso, Maki Ueki, Hiroshi Sakai-Tagawa, Yuko Lopes, Tiago Armbrust, Tammy Balogh, Aaron Chiba, Shiho Furusawa, Yuri Guan, Lizheng Hattori, Shin-Ichiro Kinoshita, Noriko Loeber, Samantha Mitsuya, Hiroaki Okuda, Moe Takada, Kosuke Ujie, Michiko Yamada, Shinya Yasuhara, Atsuhiro
Source	Medline; PMC
abstract	At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2−infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and regions of lung consolidation. SARS-CoV-2−infected hamsters mounted neutralizing antibody responses and were protected against subsequent rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naïve hamsters efficiently suppressed the replication of the virus in the lungs even when the serum was administrated 2 d postinfection of the serum-treated hamsters. Collectively, these findings demonstrate that this Syrian hamster model will be useful for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral drugs.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1073/pnas.2009799117
bibo:pmid	32571934
has license	cc-by
sha1sum (hex)	182cccfe40e533685e08895cbb0f2c990a685265
schema:url	https://doi.org/10.1073/pnas.2009799117
resource representing a document's title	Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
has PubMed Central identifier	PMC7368255
has PubMed identifier	32571934
schema:publication	Proc Natl Acad Sci U S A
resource representing a document's body	covid:182cccfe40e533685e08895cbb0f2c990a685265#body_text
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