About: Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City

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About: Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City
Creator	Yang, Jie Horwitz, Leora Jones, Simon Bosworth, Brian Cerfolio, Robert Francois, Fritz Chernyak, Yelena Petrilli, Christopher Rajagopalan, Harish Tobin, Katie Chatfield, Steven Doonan, Thomas Grossman, Robert O'donnell, Luke
source	MedRxiv
abstract	Background: Little is known about factors associated with hospitalization and critical illness in Covid-19 positive patients. Methods: We conducted a cross-sectional analysis of all patients with laboratory-confirmed Covid-19 treated at a single academic health system in New York City between March 1, 2020 and April 2, 2020, with follow up through April 7, 2020. Primary outcomes were hospitalization and critical illness (intensive care, mechanical ventilation, hospice and/or death). We conducted multivariable logistic regression to identify risk factors for adverse outcomes, and maximum information gain decision tree classifications to identify key splitters. Results: Among 4,103 Covid-19 patients, 1,999 (48.7%) were hospitalized, of whom 981/1,999 (49.1%) have been discharged home, and 292/1,999 (14.6%) have died or were discharged to hospice. Of 445 patients requiring mechanical ventilation, 162/445 (36.4%) have died. Strongest hospitalization risks were age [≥]75 years (OR 66.8, 95% CI, 44.7-102.6), age 65-74 (OR 10.9, 95% CI, 8.35-14.34), BMI>40 (OR 6.2, 95% CI, 4.2-9.3), and heart failure (OR 4.3 95% CI, 1.9-11.2). Strongest critical illness risks were admission oxygen saturation <88% (OR 6.99, 95% CI 4.5-11.0), d-dimer>2500 (OR 6.9, 95% CI, 3.2-15.2), ferritin >2500 (OR 6.9, 95% CI, 3.2-15.2), and C-reactive protein (CRP) >200 (OR 5.78, 95% CI, 2.6-13.8). In the decision tree for admission, the most important features were age >65 and obesity; for critical illness, the most important was SpO2<88, followed by procalcitonin >0.5, troponin <0.1 (protective), age >64 and CRP>200. Conclusions: Age and comorbidities are powerful predictors of hospitalization; however, admission oxygen impairment and markers of inflammation are most strongly associated with critical illness.
has issue date	2020-04-11(xsd:dateTime)
bibo:doi	10.1101/2020.04.08.20057794
has license	medrxiv
sha1sum (hex)	17eb1cbb31966fecf26e13f101e8680d1a29a4a9
schema:url	https://doi.org/10.1101/2020.04.08.20057794
resource representing a document's title	Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City
resource representing a document's body	covid:17eb1cbb31966fecf26e13f101e8680d1a29a4a9#body_text
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