About: Yu Ping Feng San, an Ancient Chinese Herbal Decoction Containing Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, Regulates the Release of Cytokines in Murine Macrophages

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About: Yu Ping Feng San, an Ancient Chinese Herbal Decoction Containing Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, Regulates the Release of Cytokines in Murine Macrophages Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Yu Ping Feng San, an Ancient Chinese Herbal Decoction Containing Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, Regulates the Release of Cytokines in Murine Macrophages
Creator	Choi, Rcy Dong, Ttx Du, Cyq Lau, Dtw Zheng, Kyz
Source	Medline; PMC
abstract	Yu Ping Feng San (YPFS), a Chinese herbal decoction, is composed of Astragali Radix (AR; Huangqi), Atractylodis Macrocephalae Rhizoma (AMR; Baizhu) and Saposhnikoviae Radix (SR; Fangfeng) in a weight ratio of 1∶2∶1. Clinically, YPFS has been widely used to regulate immune functions; however, the action mechanism of it is not known. Here, we addressed this issue by providing detail analyses of chemical and biological properties of YPFS. By using rapid resolution liquid chromatography coupled with mass spectrometry, fifteen chemicals deriving from different herbs of YPFS were determined, and which served as a control for the standardization of the herbal extract of YPFS. In general, the amounts of chosen chemical markers were higher in a preparation of YPFS as compared to that of single herb or two-herb compositions. In order to reveal the immune functions of YPFS, the standardized extract was applied onto cultured murine macrophages. The treatment of YPFS stimulated the mRNA and protein expressions of pro-inflammatory cytokines via activation of NF-κB by enhancing IκBα degradation. In contrast, the application of YPFS suppressed the expressions of pro-inflammatory cytokines significantly in the lipopolysaccharide (LPS)-induced chronic inflammation model. In addition, YPFS could up regulate the phagocytic activity in cultured macrophages. These results therefore supported the bi-directional immune-modulatory roles of YPFS in regulating the releases of cytokines from macrophages.
has issue date	2013-11-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0078622
bibo:pmid	24244327
has license	cc-by
sha1sum (hex)	17a425d3e66241ada9c347aa0e0387231be31dcd
schema:url	https://doi.org/10.1371/journal.pone.0078622
resource representing a document's title	Yu Ping Feng San, an Ancient Chinese Herbal Decoction Containing Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, Regulates the Release of Cytokines in Murine Macrophages
has PubMed Central identifier	PMC3823765
has PubMed identifier	24244327
schema:publication	PLoS One
resource representing a document's body	covid:17a425d3e66241ada9c347aa0e0387231be31dcd#body_text
is schema:about of	named entity 'DECOCTION' named entity 'SAPOSHNIKOVIAE RADIX' named entity 'resolution' named entity 'chemical' named entity 'San' named entity 'control' named entity 'determined' named entity 'RADIX' named entity 'APPLIED' named entity 'APPLICATION' named entity 'MURINE MACROPHAGES' named entity 'BI-DIRECTIONAL' named entity 'GENERAL' named entity 'MASS SPECTROMETRY' named entity 'ISSUE' named entity 'IKBA' named entity 'PREPARATION' named entity 'DIFFERENT' named entity 'HERB' named entity 'ASTRAGALI' named entity 'YU PING FENG SAN' named entity 'RHIZOMA' named entity 'CONTAINING' named entity 'HERBAL' named entity 'CYTOKINES' named entity 'HUANGQI' named entity 'EXTRACT' named entity 'USING' named entity 'HERE' named entity 'DEGRADATION' named entity 'ADDITION' named entity 'ACTIVITY' named entity 'CHINESE' named entity 'MACROPHAGES' named entity 'RELEASES' named entity 'CONTRAST' named entity 'COMPARED' named entity 'RHIZOMA' named entity 'LIQUID CHROMATOGRAPHY ' named entity 'HERBS' named entity 'NOT KNOWN' named entity 'MRNA' named entity 'DECOCTION' named entity 'SUPPORTED' named entity 'STIMULATED' named entity 'HERBAL' named entity 'REGULATE' named entity 'DETERMINED' named entity 'CYTOKINES' named entity 'TO REGULATE' named entity 'SUPPRESSED' named entity 'HIGHER' named entity 'CHOSEN' named entity 'SINGLE' named entity 'ENHANCING' named entity 'WEIGHT RATIO' named entity 'NF-KB' named entity 'MARKERS' named entity 'ORDER' named entity 'SAPOSHNIKOVIAE RADIX' named entity 'LIPOPOLYSACCHARIDE' named entity 'THESE' named entity 'TREATMENT' named entity 'BIOLOGICAL PROPERTIES' named entity 'MURINE MACROPHAGES' named entity 'PROVIDING' named entity 'ASTRAGALI' named entity 'REGULATING' named entity 'MODEL' named entity 'DERIVING' named entity 'ROLES' named entity 'EXPRESSIONS' named entity 'COMPOSITIONS' named entity 'PRO-' named entity 'FUNCTIONS' named entity 'RADIX' named entity 'CHRONIC INFLAMMATION'

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