About: Proteome analysis of porcine epidemic diarrhea virus (PEDV)‐infected Vero cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proteome analysis of porcine epidemic diarrhea virus (PEDV)‐infected Vero cells
Creator	Chen, Huanchun Zhang, Huan Fang, Liurong Luo, Rui Xiao, Shaobo Ding, Zhen Zeng, Songlin Bi, Jing Liu, Lianzeng Kang, An
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV) causes an acute, highly contagious, and devastating viral enteric disease with a high mortality rate in suckling pigs. A large‐scale outbreak of PED occurred in China in 2010, with PEDV emerging in the United States in 2013 and spreading rapidly, posing significant economic and public health concerns. In this study, LC–MS/MS coupled to iTRAQ labeling was used to quantitatively identify differentially expressed cellular proteins in PEDV‐infected Vero cells. We identified 49 differentially expressed cellular proteins, of which 8 were upregulated and 41 downregulated. These differentially expressed proteins were involved in apoptosis, signal transduction, and stress responses. Based on these differentially expressed proteins, we propose that PEDV might utilize apoptosis and extracellular signal regulated kinases pathways for maximum viral replication. Our study is the first attempt to analyze the protein profile of PEDV‐infected cells by quantitative proteomics, and we believe our findings provide valuable information with respect to better understanding the host response to PEDV infection.
has issue date	2015-03-09(xsd:dateTime)
bibo:doi	10.1002/pmic.201400458
bibo:pmid	25604190
has license	no-cc
sha1sum (hex)	17747929d55f7d936082e7b1459b9b4a54deea1e
schema:url	https://doi.org/10.1002/pmic.201400458
resource representing a document's title	Proteome analysis of porcine epidemic diarrhea virus (PEDV)‐infected Vero cells
has PubMed Central identifier	PMC7167732
has PubMed identifier	25604190
schema:publication	Proteomics
resource representing a document's body	covid:17747929d55f7d936082e7b1459b9b4a54deea1e#body_text
is schema:about of	named entity 'enteric' named entity 'involved' named entity 'cells' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'REGULATED' named entity 'suckling' named entity 'posing' named entity 'Vero' named entity 'cellular proteins' named entity 'high' named entity 'kinases' named entity '2010' named entity 'proteins' named entity 'highly' named entity 'ion' named entity 'NanoSpray' named entity 'PEDV' named entity 'porcine circovirus' named entity 'host response' named entity 'inoculation' named entity 'hpi' named entity 'host cells' named entity 'mass spectrometer' named entity 'HIV' named entity 'BALB/c' named entity 'Invitrogen' named entity 'Peptide' named entity 'toxicity' named entity 'HSP27' named entity 'downregulation' named entity 'premature death' named entity 'LC-MS/MS' named entity 'GenBank' named entity 'PEDV' named entity 'false discovery rate' named entity 'Cell nuclei' named entity 'DTT' named entity 'infection' named entity 'apoptosis' named entity 'viral protein' named entity 'gene' named entity 'adenylyl cyclase' named entity 'proteomics' named entity 'UniProt' named entity 'United States' named entity 'infection' named entity 'IPA' named entity 'ERK1/2' named entity 'viral infection' named entity 'coronaviruses' named entity 'ERK1/2' named entity 'Ebola' named entity 'PEDV' named entity 'Vero cells' named entity 'polyclonal antibody' named entity 'Tris-buffered saline' named entity 'gene expression profiles' named entity 'actin cytoskeletal remodeling' named entity 'HSP27' named entity 'biological processes' named entity 'MEK1/2' named entity 'PEDV' named entity 'tyrosine 3-monooxygenase' named entity 'streptomycin' named entity 'enterovirus 71' named entity 'protein' named entity 'apoptotic' named entity 'Oxidation' named entity 'host cells' named entity 'Bioinformatics' named entity 'ATCC' named entity 'Bradford protein assay'

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