About: Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein ?

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About: Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein ? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein ?
Creator	Vankadari, Naveen
source	Elsevier; Medline; PMC
abstract	The SARS-CoV-2 pandemic is an urgent global public health emergency and warrants investigating studies on bonafide antivirals for combat. Here we report the drug target and mechanism of action of potential antiviral drug Arbidol for SARS-CoV-2 infections. Our structural and molecular dynamics studies show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impede the trimerization of spike glycoprotein, which is a key for host cell adhesion and hijacking, thus placing Arbidol as a potential drug for repurposing. This study also abets in the development of other new therapeutics for COIVD-19 disease based on Arbidol binding mode and using structure-guided drug designing.
has issue date	2020-04-28(xsd:dateTime)
bibo:doi	10.1016/j.ijantimicag.2020.105998
bibo:pmid	32360231
has license	no-cc
sha1sum (hex)	17243816131ae17b103b296d99b1f2f7cee814a4
schema:url	https://doi.org/10.1016/j.ijantimicag.2020.105998
resource representing a document's title	Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking the trimerization of viral spike glycoprotein ?
has PubMed Central identifier	PMC7187825
has PubMed identifier	32360231
schema:publication	Int J Antimicrob Agents
resource representing a document's body	covid:17243816131ae17b103b296d99b1f2f7cee814a4#body_text
is schema:about of	named entity 'Arbidol' named entity 'virus' named entity 'antiviral drug' named entity 'mode' named entity 'Hemagglutinin' named entity 'binding' named entity 'antiviral drug' named entity 'Arbidol' named entity 'glycoprotein' named entity 'CELL ADHESION' named entity 'POTENTIAL' named entity 'INFLUENZA VIRUS' named entity 'EMERGENCY' named entity 'GUIDE' named entity 'TRIMERIZATION' named entity 'inhibit' named entity 'Arbidol' named entity 'influenza' named entity 'glycoprotein' named entity 'residues' named entity 'spike' named entity 'viral' named entity 'structurer' named entity 'COVID-19' named entity 'glycoprotein' named entity 'trimerization' named entity 'SARS-CoV-2' named entity 'molecular dynamics' named entity 'homotrimer' named entity 'RMSD' named entity 'HA protein' named entity 'SARS-CoV-2' named entity 'Arbidol' named entity 'influenza virus' named entity 'Van der Waals' named entity 'glycoprotein' named entity 'Arbidol' named entity 'glycoproteins' named entity 'glycoprotein' named entity 'L99' named entity 'Arbidol' named entity 'drug target' named entity 'Arbidol' named entity 'C-Score' named entity 'Arbidol' named entity 'Arbidol' named entity 'viral protein' named entity 'SARS-CoV-2' named entity 'H3N2' named entity 'ACE2' named entity 'molecular dynamics' named entity 'Tamiflu' named entity 'antiviral drug' named entity 'SARS-CoV-2' named entity 'SARS-COV-2' named entity 'spike protein' named entity 'HA protein' named entity 'influenza' named entity 'combination of drugs' named entity 'Arbidol' named entity 'glycoprotein' named entity 'H3N2' named entity 'ACE2' named entity 'Arbidol' named entity 'Arg' named entity 'L98' named entity 'Arbidol' named entity 'H3N2' named entity 'false positive' named entity 'R54' named entity 'protomers' named entity 'RNA synthesis' named entity 'binding sites' named entity 'binding sites' named entity 'clinical investigation' named entity 'L99' named entity 'HA protein' named entity 'host membrane' named entity 'CD26' named entity 'Z-score' named entity 'cell adherence'

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