About: Differences in the epidemiology and virology of mild, severe and fatal human infections with avian influenza A (H7N9) virus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Differences in the epidemiology and virology of mild, severe and fatal human infections with avian influenza A (H7N9) virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Differences in the epidemiology and virology of mild, severe and fatal human infections with avian influenza A (H7N9) virus
Creator	Liu, Shelan Chen, Haijun Chen, • Ren, Yajin Sha, Jianping Zhang, Zhiruo Dong, • Wu, Zuqun
Source	PMC
abstract	A novel avian influenza A (H7N9) virus caused 5-10 % mild and 30.5 % fatal human infections as of December 10, 2015. In order to investigate the reason for the higher rate of fatal outcome of this infection, this study compared the molecular epidemiology and virology of avian influenza A (H7N9) viruses from mild (N = 14), severe (N = 50) and fatal (N = 35) cases, as well as from non-human hosts (N = 73). The epidemiological results showed that the average age of the people in the mild, severe and fatal groups was 27.6, 52 and 62 years old, respectively (p < 0.001). Males accounted for 42.9 % (6/14), 58.0 % (29/50), and 74.3 % (26/35) of cases in the mild, severe and fatal group respectively (p = 0.094). Median days from onset to start of antiviral treatment were 2, 5 and 7 days in the mild, severe and fatal group, respectively (p = 0.002). The median time from onset to discharge/death was 12, 40 and 19 days in the mild, severe and fatal group, respectively (p < 0.001). Analysis of whole genome sequences showed that PB2 (E627K), NA (R294K) and PA (V100A) mutations were markedly associated with an increased fatality rate, while HA (N276D) and PB2 (N559T) mutations were clearly related to mild cases. There were no differences in the genotypes, adaptation to mammalian hosts, and genetic identity between the three types of infection. In conclusion, advanced age and delayed confirmation of diagnosis and antiviral intervention were risk factors for death. Furthermore, PB2 (E627K), NA (R294K) and PA (V100A) mutations might contribute to a fatal outcome in human H7N9 infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00705-016-2781-3) contains supplementary material, which is available to authorized users.
has issue date	2016-02-18(xsd:dateTime)
bibo:doi	10.1007/s00705-016-2781-3
bibo:pmid	26887968
has license	no-cc
sha1sum (hex)	170eb018c43083eef1333bc6ff6ffd95d19a9a96
schema:url	https://doi.org/10.1007/s00705-016-2781-3
resource representing a document's title	Differences in the epidemiology and virology of mild, severe and fatal human infections with avian influenza A (H7N9) virus
has PubMed Central identifier	PMC7101734
has PubMed identifier	26887968
schema:publication	Arch Virol
resource representing a document's body	covid:170eb018c43083eef1333bc6ff6ffd95d19a9a96#body_text
is schema:about of	named entity 'avian influenza' named entity 'genotypes' named entity 'discharge' named entity 'epidemiological' named entity 'fatal' named entity 'infections' named entity 'MUTATIONS' named entity 'IDENTITY' named entity 'DECEMBER' named entity 'time' named entity 'genome' named entity 'onset' named entity 'severe' named entity 'cases' named entity 'order' named entity 'genetic' named entity 'virus' named entity 'age' named entity 'fatal' named entity 'avian influenza' named entity 'higher' named entity 'virus' named entity 'genotypes' named entity 'H7N9' named entity 'molecular epidemiology' named entity 'average age' named entity 'avian influenza' named entity 'viruses' named entity 'risk factors' named entity 'fatality rate' named entity 'antiviral treatment' named entity 'infection' named entity 'gene' named entity 'Anhui' named entity 'Guangdong Province' named entity 'virus' named entity 'epidemiology' named entity 'virus' named entity 'influenza' named entity 'host adaptation' named entity 'avian influenza' named entity 'mutation' named entity 'virus infection' named entity 'H7N7' named entity 'avian influenza' named entity 'gene' named entity 'immunosuppressive' named entity 'genotypes' named entity 'statistically significant' named entity 'contingency tables' named entity 'neuraminidase' named entity 'informed consent' named entity 'mutation' named entity 'genotypes' named entity 'analysis of variance' named entity 'H7N9' named entity 'mutation rate' named entity 'geocoding' named entity 'infection' named entity 'Fisher's exact test' named entity 'chicken' named entity 'statistically significantly' named entity 'lung' named entity 'epidemic' named entity 'H7N9' named entity 'H7N9' named entity 'mutation' named entity 'antiviral treatment' named entity 'genome sequences' named entity 'ARDS' named entity 'codon' named entity 'Evolutionary relationships' named entity 'amino acid' named entity 'sequence identity'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software