About: Pathogenicity of three genetically diverse strains of PRRSV Type 1 in specific pathogen free pigs

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About: Pathogenicity of three genetically diverse strains of PRRSV Type 1 in specific pathogen free pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenicity of three genetically diverse strains of PRRSV Type 1 in specific pathogen free pigs
Creator	Botti, Sara Bøtner, Anette Nielsen, Jens Podgórska, Katarzyna Stadejek, Tomasz Dolka, Izabella Fabisiak, Michał Huć, Tomasz Sapierzyński, Rafał Heegaard, Peter Larsen, Lars Hjulsager, Charlotte Kvisgaard, Lise
Source	Elsevier; Medline; PMC
abstract	Abstract Studies from Eastern European countries proved that porcine reproductive and respiratory syndrome virus Type 1 (PRRSV-1) harbours high genetic diversity and that genetically divergent subtypes 2–4 circulate in this area. In the present study, we compared the pathogenicity of two different PRRSV-1 subtype 2 strains and a strain representing PRRSV-1 subtype 1. Four groups of 8-week-old specific pathogen free pigs were either infected with subtype 2 strain ILI6, subtype 2 strain or BOR59, subtype 1 strain 18794, or mock inoculated. The most pronounced clinical signs were observed in pigs infected with BOR59. Pigs from both subtype 2 strain infected groups exhibited significantly elevated mean body temperatures on DPI 2 compared to the other two groups, the difference remaining significant up to DPI 13 for the BOR59 group, only. The pigs in the latter group also displayed significantly highest levels of early viremia together with the most rapid APP response. Overall, the results indicated that BOR59 strain can be considered a highly pathogenic strain, similarly to subtype 3 strains Lena and SU1-bel, while the virulence of the other subtype 2 strain ILI6 was intermediate between BOR59 and subtype 1 strain.
has issue date	2017-09-30(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2017.05.011
bibo:pmid	28554869
has license	els-covid
sha1sum (hex)	16806b7011f228853fde6f0a67cc11bbf4b448f9
schema:url	https://doi.org/10.1016/j.vetmic.2017.05.011
resource representing a document's title	Pathogenicity of three genetically diverse strains of PRRSV Type 1 in specific pathogen free pigs
has PubMed Central identifier	PMC7127113
has PubMed identifier	28554869
schema:publication	Veterinary Microbiology
resource representing a document's body	covid:16806b7011f228853fde6f0a67cc11bbf4b448f9#body_text
is schema:about of	named entity 'genetically diverse' named entity 'STRAINS' named entity 'EASTERN EUROPEAN' named entity 'SUBTYPES' named entity 'GENETIC DIVERSITY' named entity 'TYPE 1' named entity 'PATHOGEN' named entity 'AREA' named entity 'TYPE 1' named entity 'PIGS' named entity 'PRRSV' named entity 'PATHOGENICITY' named entity 'CIRCULATE' named entity 'STUDIES' named entity 'VIRUS TYPE' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'HIGH' named entity 'COUNTRIES' named entity 'DIVERSE' named entity 'SPECIFIC' named entity 'FREE' covid:arg/16806b7011f228853fde6f0a67cc11bbf4b448f9 named entity 'area' named entity 'genetically diverse' named entity 'Pathogenicity' named entity 'Lelystad' named entity 'genotype' named entity 'Brucella' named entity 'Europe' named entity 'seroconversion' named entity 'present antigens' named entity 'eosinophils' named entity 'ILI' named entity 'viremia' named entity '2, 3' named entity 'viremia' named entity 'Antibodies' named entity 'Danish' named entity 'cytomegalovirus' named entity 'East European' named entity 'acute phase protein' named entity 'light microscope' named entity 'histopathological' named entity 'coagulate' named entity 'transmissible gastroenteritis virus' named entity 'IPMA' named entity 'virulence' named entity 'IL-6' named entity 'immunological responses' named entity 'viruses' named entity 'antigenic' named entity 'virus' named entity 'Euthanasia' named entity 'inflammation' named entity 'Brachyspira' named entity 'Belgium' named entity 'fever' named entity 'virulent' named entity 'Arteriviridae' named entity 'fever' named entity 'APP' named entity 'RT-PCR' named entity 'fever' named entity 'virulent' named entity 'euthanasia' named entity 'inocula' named entity 'stained with haematoxylin and eosin' named entity 'phagocytosis' named entity 'body temperatures'

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