About: Dynamics and Differences in Systemic and Local Immune Responses After Vaccination With Inactivated and Live Commercial Vaccines and Subsequent Subclinical Infection With PRRS Virus

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About: Dynamics and Differences in Systemic and Local Immune Responses After Vaccination With Inactivated and Live Commercial Vaccines and Subsequent Subclinical Infection With PRRS Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dynamics and Differences in Systemic and Local Immune Responses After Vaccination With Inactivated and Live Commercial Vaccines and Subsequent Subclinical Infection With PRRS Virus
Creator	Huang, Jinhai Fraile, Lorenzo Butler, John Celer, Vladimir Faldyna, Martin Frolichova, Jitka Kavanová, Lenka Kudláčková, Hana Levá, Lenka Nechvátalová, Kateřina Ondráčková, Petra Salat, Jiri Toman, Miroslav
source	PMC
abstract	The goals of our study were to compare the immune response to different killed and modified live vaccines against PRRS virus and to monitor the antibody production and the cell mediated immunity both at the systemic and local level. In the experiment, we immunized four groups of piglets with two commercial inactivated (A1—Progressis, A2—Suivac) and two modified live vaccines (B3—Amervac, B4—Porcilis). Twenty-one days after the final vaccination, all piglets, including the control non-immunized group (C5), were i.n., infected with the Lelystad strain of PRRS virus. The serum antibody response (IgM and IgG) was the strongest in group A1 followed by two MLV (B3 and B4) groups. Locally, we demonstrated the highest level of IgG antibodies in bronchoalveolar lavages (BALF), and saliva in group A1, whereas low IgA antibody responses in BALF and feces were detected in all groups. We have found virus neutralization antibody at DPV 21 (days post vaccination) and higher levels in all groups including the control at DPI 21 (days post infection). Positive antigen specific cell-mediated response in lymphocyte transformation test (LTT) was observed in groups B3 and B4 at DPV 7 and in group B4 at DPV 21 and in all intervals after infection. The IFN-γ producing lymphocytes after antigen stimulation were found in CD4(−)CD8(+) and CD4(+)CD8(+) subsets of all immunized groups 7 days after infection. After infection, there were obvious differences in virus excretion. The virus was detected in all groups of piglets in serum, saliva, and occasionally in feces at DPI 3. Significantly lower virus load was found in groups A1 and B3 at DPI 21. Negative samples appeared at DPI 21 in B3 group in saliva. It can be concluded that antibodies after immunization and infection, and the virus after infection can be detected in all the compartments monitored. Immunization with inactivated vaccine A1—Progressis induces high levels of antibodies produced both systemically and locally. Immunization with MLV-vaccines (Amervac and Porcilis) produces sufficient antibody levels and also cell-mediated immunity. After infection virus secretion gradually decreases in group B3, indicating tendency to induce sterile immunity.
has issue date	2019-08-06(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.01689
bibo:pmid	31447829
has license	cc-by
sha1sum (hex)	166ac544dda68154d0cfb96da75f30e457d6eda2
schema:url	https://doi.org/10.3389/fimmu.2019.01689
resource representing a document's title	Dynamics and Differences in Systemic and Local Immune Responses After Vaccination With Inactivated and Live Commercial Vaccines and Subsequent Subclinical Infection With PRRS Virus
has PubMed Central identifier	PMC6691355
has PubMed identifier	31447829
schema:publication	Front Immunol
resource representing a document's body	covid:166ac544dda68154d0cfb96da75f30e457d6eda2#body_text
is schema:about of	named entity 'INACTIVATED' named entity 'SYSTEMIC' named entity 'IMMUNE RESPONSES' named entity 'Immune' named entity 'SUBSEQUENT' named entity 'VACCINES' named entity 'VIRUS' named entity 'MLV' named entity 'GROUP' named entity 'ANTIBODIES' named entity 'TENDENCY' named entity 'CELL-MEDIATED IMMUNITY' named entity 'SUFFICIENT' named entity 'LOCALLY' named entity 'IMMUNITY' named entity 'STERILE' named entity 'ANTIBODY' named entity 'DECREASES' named entity 'LEVELS' named entity 'SUBCLINICAL INFECTION' named entity 'IMMUNIZATION' named entity 'HIGH' named entity 'COMMERCIAL' named entity 'PRRS' named entity 'DYNAMICS' named entity 'VACCINATION' named entity 'LIVE' named entity 'INDICATING' named entity 'SECRETION' named entity 'LOCAL' named entity 'INDUCE' named entity 'INFECTION VIRUS' named entity 'VACCINES' covid:arg/166ac544dda68154d0cfb96da75f30e457d6eda2 named entity 'produced' named entity 'infection' named entity 'With' named entity 'high levels' named entity 'secretion' named entity 'infection' named entity 'vaccines' named entity 'antibody' named entity 'Incubation' named entity 'cytokines' named entity 'infection' named entity 'skimmed milk' named entity 'MLV' named entity 'excretion' named entity 'RNA' named entity 'virus' named entity 'pre-stained' named entity 'antigen' named entity 'vaccine' named entity 'IgA antibodies' named entity 'IgG antibodies' named entity 'plaque forming units' named entity 'MLV' named entity 'IgM' named entity 'infection' named entity 'MLV' named entity 'cytopathic effect' named entity 'vaccination' named entity 'pathogenic strains' named entity 'vaccination' named entity '21 days' named entity 'viral replication' named entity 'IgG' named entity 'intramuscular' named entity 'respiratory tract'

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