About: Discovery of a highly divergent hepadnavirus in shrews from China

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Discovery of a highly divergent hepadnavirus in shrews from China
Creator	Tian, Jun-Hua Yu, Bin Zhang, Yong-Zhen Lin, Xian-Dan Xing, Jian-Guang Holmes, Edward Cao, Jian-Hai Ma, Runlin Nie, Fang-Yuan
source	Elsevier; Medline; PMC
abstract	Abstract Limited sampling means that relatively little is known about the diversity and evolutionary history of mammalian members of the Hepadnaviridae (genus Orthohepadnavirus). An important case in point are shrews, the fourth largest group of mammals, but for which there is limited knowledge on the role they play in viral evolution and emergence. Here, we report the discovery of a novel shrew hepadnavirus. The newly discovered virus, denoted shrew hepatitis B virus (SHBV), is divergent to be considered a new species of Orthohepadnavirus. Phylogenetic analysis revealed that these viruses were usually most closely related to TBHBV (tent-making bat hepatitis B virus), known to be able to infect human hepatocytes, and had a similar genome structure, although SHBV fell in a more basal position in the surface protein phylogeny. In sum, these data suggest that shrews are natural hosts for hepadnaviruses and may have played an important role in their long-term evolution.
has issue date	2019-05-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2019.03.007
bibo:pmid	30884426
has license	els-covid
sha1sum (hex)	164d50a7a82adec4cb583088f25bcfa384844000
schema:url	https://doi.org/10.1016/j.virol.2019.03.007
resource representing a document's title	Discovery of a highly divergent hepadnavirus in shrews from China
has PubMed Central identifier	PMC7172195
has PubMed identifier	30884426
schema:publication	Virology
resource representing a document's body	covid:164d50a7a82adec4cb583088f25bcfa384844000#body_text
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