About: Pulmonary fibrosis induced by H5N1 viral infection in mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pulmonary fibrosis induced by H5N1 viral infection in mice
Creator	Qiao, Jian Wang, Xun Zhao, Lihong He, Guimei Bi, Jianmin Deng, Guangcun Luan, Zhihua Lv, Nana Xu, Tong Zhang, Miaojie
Source	Medline; PMC
abstract	BACKGROUND: Inflammatory process results in lung injury that may lead to pulmonary fibrosis (PF). Here, we described PF in mice infected with H5N1 virus. METHODS: Eight-week-old BALB/c mice were inoculated intranasally with 1 × 10(1 )MID(50 )of A/Chicken/Hebei/108/2002(H5N1) viruses. Lung injury/fibrosis was evaluated by observation of hydroxyproline concentrations, lung indexes, and histopathology on days 7, 14, and 30 postinoculation. RESULTS: H5N1-inoculated mice presented two stages of pulmonary disease over a 30-d period after infection. At acute stage, infected-mice showed typical diffuse pneumonia with inflammatory cellular infiltration, alveolar and interstitial edema and hemorrhage on day 7 postinoculation. At restoration stage, most infected-mice developed PF of different severities on day 30 postinoculation, and 18% of the survived mice underwent severe interstitial and intra-alveolar fibrosis with thickened alveolar walls, collapsed alveoli and large fibrotic areas. The dramatically elevated hydroxyproline levels in H5N1-infected mice showed deposition of collagen in lungs, and confirmed fibrosis of lungs. The dry lung-to-body weight ratio was significantly increased in infected group, which might be associated with the formation of PF in H5N1-infected mice. CONCLUSION: Our findings show that H5N1-infected mice develop the typical PF during restoration period, which will contribute to the investigation of fibrogenesis and potential therapeutic intervention in human H5N1 disease.
has issue date	2009-11-12(xsd:dateTime)
bibo:doi	10.1186/1465-9921-10-107
bibo:pmid	19909524
has license	cc-by
sha1sum (hex)	1638100b254164ee9af7d66be61794a7efa07b78
schema:url	https://doi.org/10.1186/1465-9921-10-107
resource representing a document's title	Pulmonary fibrosis induced by H5N1 viral infection in mice
has PubMed Central identifier	PMC2783028
has PubMed identifier	19909524
schema:publication	Respir Res
resource representing a document's body	covid:1638100b254164ee9af7d66be61794a7efa07b78#body_text
is schema:about of	named entity 'RESEARCH' named entity 'pulmonary fibrosis' named entity 'Pulmonary fibrosis' named entity 'PULMONARY FIBROSIS' named entity 'MICE' named entity 'H5N1 VIRUS' named entity 'BACKGROUND' named entity 'RESULTS' named entity 'PULMONARY FIBROSIS' named entity 'LUNG INJURY' named entity 'LEAD' named entity 'RESPIRATORY' named entity 'H5N1' named entity 'VIRAL INFECTION' named entity 'INFLAMMATORY PROCESS' named entity 'DESCRIBED' named entity 'INDUCED' named entity 'MICE' named entity 'HERE' named entity 'INFECTED' covid:arg/1638100b254164ee9af7d66be61794a7efa07b78 named entity 'H5N1' named entity 'hemorrhage' named entity 'avian influenza A' named entity 'Histopathological' named entity 'H5N1' named entity 'lung edema' named entity 'H5N1' named entity 'mice' named entity 'infection' named entity 'cough' named entity 'hydroxyproline' named entity 'avian influenza' named entity 'fibrosis' named entity 'mice' named entity 'Oxidation' named entity 'cell proliferation' named entity 'mice' named entity 'World Health Organization' named entity 'Animal Care' named entity 'mice' named entity 'H5N1' named entity 'inflammatory state' named entity 'body weight' named entity 'Chicken' named entity 'Virus' named entity 'intranasally' named entity 'exudative' named entity 'virus' named entity 'edema' named entity 'pulmonary fibrosis' named entity 'edema' named entity 'Chicken' named entity 'body weight' named entity 'H5N1' named entity 'ARDS' named entity 'H5N1' named entity 'viruses' named entity 'infection' named entity 'lungs' named entity 'TGF-β' named entity 'inflammatory process' named entity 'mice' named entity 'alveolar' named entity 'small blood vessels' named entity 'inflammatory cells' named entity 'interstitial fibrosis' named entity 'stenosis' named entity 'mice' named entity 'body weight' named entity 'mice' named entity 'fibrotic'

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