About: Myeloid Cells during Viral Infections and Inflammation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Myeloid Cells during Viral Infections and Inflammation
Creator	Wootton, Sarah Karimi, Khalil Bridle, Byram Klafuric, Elaine Minott, Jessica Mould, Robert Stegelmeier, Ashley Van Vloten, Jacob
Source	Medline; PMC
abstract	Myeloid cells represent a diverse range of innate leukocytes that are crucial for mounting successful immune responses against viruses. These cells are responsible for detecting pathogen-associated molecular patterns, thereby initiating a signaling cascade that results in the production of cytokines such as interferons to mitigate infections. The aim of this review is to outline recent advances in our knowledge of the roles that neutrophils and inflammatory monocytes play in initiating and coordinating host responses against viral infections. A focus is placed on myeloid cell development, trafficking and antiviral mechanisms. Although known for promoting inflammation, there is a growing body of literature which demonstrates that myeloid cells can also play critical regulatory or immunosuppressive roles, especially following the elimination of viruses. Additionally, the ability of myeloid cells to control other innate and adaptive leukocytes during viral infections situates these cells as key, yet under-appreciated mediators of pathogenic inflammation that can sometimes trigger cytokine storms. The information presented here should assist researchers in integrating myeloid cell biology into the design of novel and more effective virus-targeted therapies.
has issue date	2019-02-19(xsd:dateTime)
bibo:doi	10.3390/v11020168
bibo:pmid	30791481
has license	cc-by
sha1sum (hex)	162ffba72e95c4b2686b0b273b47c376aad61ba7
schema:url	https://doi.org/10.3390/v11020168
resource representing a document's title	Myeloid Cells during Viral Infections and Inflammation
has PubMed Central identifier	PMC6410039
has PubMed identifier	30791481
schema:publication	Viruses
resource representing a document's body	covid:162ffba72e95c4b2686b0b273b47c376aad61ba7#body_text
is schema:about of	named entity 'ability' named entity 'myeloid' named entity 'neutrophils' named entity 'literature' named entity 'Inflammation' named entity 'Viral' named entity 'VIRAL INFECTIONS' named entity 'TARGETED' named entity 'OUTLINE' named entity 'MITIGATE' named entity 'DESIGN' named entity 'RESULTS' named entity 'MYELOID CELLS' named entity 'MONOCYTES' named entity 'INITIATING' named entity 'RESPONSES' named entity 'KEY' named entity 'OUR' named entity 'CELL BIOLOGY' named entity 'BODY' named entity 'EFFECTIVE' named entity 'IMMUNE RESPONSES' named entity 'IS A' named entity 'PATTERNS' named entity 'PLACED' named entity 'INFLAMMATION' named entity 'CELLS' named entity 'KNOWN' named entity 'MOLECULAR' named entity 'COORDINATING' named entity 'PROMOTING' named entity 'VIRUS' named entity 'ANTIVIRAL' named entity 'TO CONTROL' named entity 'RANGE' named entity 'PLAY' named entity 'SIGNALING CASCADE' named entity 'SUCCESSFUL' named entity 'NOVEL' named entity 'VIRUSES' named entity 'REPRESENT' named entity 'MYELOID CELL DEVELOPMENT' named entity 'ROLES' named entity 'AIM' named entity 'INFLAMMATORY' named entity 'CYTOKINE ' named entity 'ASSIST' named entity 'MEDIATORS' named entity 'INFORMATION' named entity 'INFECTIONS' named entity 'DIVERSE' named entity 'ABILITY' named entity 'NEUTROPHILS' named entity 'RECENT' covid:arg/162ffba72e95c4b2686b0b273b47c376aad61ba7 named entity 'MYELOID CELL' named entity 'IMMUNOSUPPRESSIVE' named entity 'ADAPTIVE' named entity 'VIRUSES' named entity 'THESE' named entity 'MYELOID CELLS' named entity 'INFLAMMATION' named entity 'LEUKOCYTES' named entity 'VIRAL INFECTIONS' named entity 'STORMS' named entity 'CYTOKINES' named entity 'PRODUCTION' named entity 'RESPONSIBLE' named entity 'TRAFFICKING' named entity 'FOCUS' named entity 'LITERATURE' named entity 'KNOWLEDGE' named entity 'TRIGGER' named entity 'FOLLOWING'

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