About: Human rhinovirus infections of the lower respiratory tract in hematopoietic stem cell transplant recipients

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About: Human rhinovirus infections of the lower respiratory tract in hematopoietic stem cell transplant recipients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human rhinovirus infections of the lower respiratory tract in hematopoietic stem cell transplant recipients
Creator	Jacobs, S Jenkins, S Magro, C Satlin, M Schuetz, A Shore, T Soave, R Walsh, T
Source	Medline; PMC
abstract	BACKGROUND: Human rhinoviruses (HRVs) are a common cause of upper respiratory infection (URI) in hematopoietic stem cell transplant (HSCT) recipients; yet, their role in lower respiratory illness is not well understood. METHODS: We performed a retrospective chart review of HSCT recipients with HRV infection from the time molecular detection methods were implemented at our institution in 2008. Factors associated with proven or possible HRV pneumonia at the first HRV detection were evaluated by univariate and multivariate analysis. We then characterized all episodes of proven and possible HRV pneumonia from the initial HRV infection through a 1-year follow-up period. RESULTS: Between 2008 and 2011, 63 HSCT recipients had ≥ 1 documented HRV infections. At first HRV detection, 36 (57%) patients had HRV URI and 27 (43%) had proven or possible HRV pneumonia; in multivariate analysis, hypoalbuminemia (odds ratio [OR] 9.5, 95% confidence interval [CI] 1.3–71.7; P=0.03) and isolation of respiratory co-pathogen(s) (OR 24.2, 95%CI 2.0–288.4; P=0.01) were independently associated with pneumonia. During the study period, 22 patients had 25 episodes of proven HRV pneumonia. Fever (60%), cough (92%), sputum production (61%), and dyspnea (60%) were common symptoms. Fifteen (60%) episodes demonstrated bacterial (n=n=7), fungal (n=n=5), or viral (n=n=3) co-infection. Among the remaining 10 (40%) cases of HRV monoinfection, patients’ oxygen saturations ranged from 80% to 97% on ambient air, and computed tomography scans showed peribronchiolar, patchy, ground glass infiltrates. CONCLUSIONS: HRV pneumonia is relatively common after HSCT and frequently accompanied by bacterial co-infection. As use of molecular assays for respiratory viral diagnosis becomes widespread, HRV will be increasingly recognized as a significant cause of pneumonia in immunocompromised hosts.
has issue date	2013-07-01(xsd:dateTime)
bibo:doi	10.1111/tid.12111
bibo:pmid	23890179
has license	green-oa
sha1sum (hex)	1625e73982540a837224c0b47243b1984b4b992c
schema:url	https://doi.org/10.1111/tid.12111
resource representing a document's title	Human rhinovirus infections of the lower respiratory tract in hematopoietic stem cell transplant recipients
has PubMed Central identifier	PMC3962254
has PubMed identifier	23890179
schema:publication	Transplant Infectious Disease
resource representing a document's body	covid:1625e73982540a837224c0b47243b1984b4b992c#body_text
is schema:about of	named entity 'NOT WELL' named entity 'CAUSE' named entity 'UNDERSTOOD' covid:arg/1625e73982540a837224c0b47243b1984b4b992c named entity 'LOWER RESPIRATORY TRACT' named entity 'RESPIRATORY ILLNESS' named entity 'LOWER' named entity 'STEM CELL TRANSPLANT' named entity 'TRANSPLANT RECIPIENTS' named entity 'INFECTIONS' named entity 'HUMAN RHINOVIRUS' named entity 'HEMATOPOIETIC STEM CELL' named entity 'A COMMON' named entity 'STEM CELL TRANSPLANT' named entity 'HEMATOPOIETIC STEM CELL' named entity 'ROLE' named entity 'HUMAN' named entity 'RHINOVIRUSES' named entity 'UPPER RESPIRATORY INFECTION' named entity 'BACKGROUND' named entity 'THEIR' named entity 'upper respiratory infection' named entity 'URI' named entity 'HSCT' named entity 'Human rhinovirus' named entity 'sputum production' named entity 'serum albumin' named entity 'antiviral' named entity 'HRV' named entity 'pathogens' named entity 'pneumonia' named entity 'pneumonia' named entity 'HRV' named entity 'pneumonia' named entity 'co-infection' named entity 'HSCT' named entity 'HRV' named entity 'allogeneic' named entity 'infection' named entity 'co-infection' named entity 'HRV' named entity 'LRTI' named entity 'HRV' named entity 'interferon' named entity 'bronchoscopy' named entity 'mechanical ventilation' named entity 'HRV' named entity 'virus' named entity 'HSCT' named entity 'URI' named entity 'viruses' named entity 'pneumonia' named entity 'desquamation' named entity 'HRV' named entity 'HRV' named entity 'bronchitis' named entity 'autologous' named entity 'infection' named entity 'HRV' named entity 'College Station, Texas' named entity 'lung' named entity 'pneumonia' named entity 'HRV' named entity 'HSCT' named entity 'HRV' named entity 'pneumonia' named entity 'co-infection' named entity 'HRV' named entity 'HRV' named entity 'emergency department' named entity 'HRV' named entity 'nasal congestion' named entity 'pneumonia' named entity 'H1N1'

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